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GNG13 G protein subunit gamma 13 [ Homo sapiens (human) ]

Gene ID: 51764, updated on 7-Jun-2020


Official Symbol
GNG13provided by HGNC
Official Full Name
G protein subunit gamma 13provided by HGNC
Primary source
See related
Ensembl:ENSG00000127588 MIM:607298
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
h2-35; G(gamma)13
Heterotrimeric G proteins, which consist of alpha (see MIM 139320), beta (see MIM 139380), and gamma subunits, function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. GNG13 is a gamma subunit that is expressed in taste, retinal, and neuronal tissues and plays a key role in taste transduction (Li et al., 2006 [PubMed 16473877]).[supplied by OMIM, Oct 2009]
Low expression observed in reference dataset See more

Genomic context

See GNG13 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (798041..800734, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (848041..850733, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene microRNA 662 Neighboring gene mesothelin like Neighboring gene RNA pseudouridine synthase domain containing 1 Neighboring gene chromosome transmission fidelity factor 18 Neighboring gene proline rich 25 Neighboring gene lipase maturation factor 1 Neighboring gene uncharacterized LOC107984876

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein beta-subunit binding IPI
Inferred from Physical Interaction
more info
GTPase activity IEA
Inferred from Electronic Annotation
more info
Process Evidence Code Pubs
phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
sensory perception of taste IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
dendrite IEA
Inferred from Electronic Annotation
more info
heterotrimeric G-protein complex IEA
Inferred from Electronic Annotation
more info
plasma membrane TAS
Traceable Author Statement
more info

General protein information

Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
G gamma subunit, clone:h2-35
guanine nucleotide binding protein (G protein), gamma 13
guanine nucleotide binding protein 13, gamma

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016541.3NP_057625.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13

    See identical proteins and their annotated locations for NP_057625.1

    Status: VALIDATED

    Source sequence(s)
    AL031033, BM931126, DA111448
    Consensus CDS
    ENSP00000248150.4, ENST00000248150.5
    Conserved Domains (1) summary
    GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    798041..800734 complement
    GenBank, FASTA, Sequence Viewer (Graphics)
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