GHRL ghrelin and obestatin prepropeptide [Homo sapiens (human)] - Gene

Summary

Official Symbol: GHRLprovided by HGNC
Official Full Name: ghrelin and obestatin prepropeptideprovided by HGNC
Primary source: HGNC:HGNC:18129
See related: Ensembl:ENSG00000157017 MIM:605353; Vega:OTTHUMG00000155360
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MTLRP
Summary: This gene encodes the ghrelin-obestatin preproprotein that is cleaved to yield two peptides, ghrelin and obestatin. Ghrelin is a powerful appetite stimulant and plays an important role in energy homeostasis. Its secretion is initiated when the stomach is empty, whereupon it binds to the growth hormone secretagogue receptor in the hypothalamus which results in the secretion of growth hormone (somatotropin). Ghrelin is thought to regulate multiple activities, including hunger, reward perception via the mesolimbic pathway, gastric acid secretion, gastrointestinal motility, and pancreatic glucose-stimulated insulin secretion. It was initially proposed that obestatin plays an opposing role to ghrelin by promoting satiety and thus decreasing food intake, but this action is still debated. Recent reports suggest multiple metabolic roles for obestatin, including regulating adipocyte function and glucose metabolism. Alternative splicing results in multiple transcript variants. In addition, antisense transcripts for this gene have been identified and may potentially regulate ghrelin-obestatin preproprotein expression. [provided by RefSeq, Nov 2014]
Expression: Biased expression in stomach (RPKM 63.9) and duodenum (RPKM 5.6) See more
Orthologs: mouse all

Genomic context

Location:: 3p25.3

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
109	current	GRCh38.p12 (GCF_000001405.38)	3	NC_000003.12 (10285750..10292947, complement)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (10327434..10334631, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

The establishment of the exact correlation between ghrelin, appetite and obesity could be vital for the fight against obesity.
Title: Ghrelin and Obesity: Identifying Gaps and Dispelling Myths. A Reappraisal.
Studied expression of In1-ghrelin splice variant in prostate cancer and its possible role in tumorigenesis and disease progression.
Title: The oncogenic role of the In1-ghrelin splicing variant in prostate cancer aggressiveness.
These results indicate that ghrelin promotes A549cell proliferation via GHSR-dependent PI3K/Akt/mTOR/P70S6K and ERK signaling pathways.
Title: Ghrelin promotes human non-small cell lung cancer A549 cell proliferation through PI3K/Akt/mTOR/P70S6K and ERK signaling pathways.
findings are the first to associate methylation levels in blood with brain activity in obesity-related regions, and further support previous findings between ghrelin, brain activity and genetic differences
Title: A DNA methylation site within the KLF13 gene is associated with orexigenic processes based on neural responses and ghrelin levels.
The results of this study showed that higher serum levels of obestatin were associated with macro albuminuria suggesting that obestatin may have a role in underlying pathogenic mechanisms that leads to diabetic nephropathy.
Title: Serum obestatin and omentin levels in patients with diabetic nephropathy.
The level of serum ghrelin might be a biomarker of executive function and become a strong predictor of executive function impairment in patients with type 2 diabetes mellitus.
Title: Ghrelin is a possible new predictor associated with executive function in patients with type 2 diabetes mellitus.
Study found three gene variants (CLOCK-rs4864548, PEMT-rs936108, and GHRELIN-rs696217) that exhibited uncorrected gene-by-sleep duration interactions in relation to BMI z-scores in a cohort of New Zealand European children. However, no interactions were identified in percentage body fat differences. Notably, these interactions are evident without detectable effects on sleep duration.
Title: Gene-by-environment interactions of the CLOCK, PEMT, and GHRELIN loci with average sleep duration in relation to obesity traits using a cohort of 643 New Zealand European children.
In short, thin children, despite elevated ghrelin production, the low IGF-I concentration is observed, probably due to undernutrition and worse IGF-I formation. In short, normal-weight children and in short, obese ones, ghrelin and IGF-I production is normal, and it seems that mechanisms responsible for their short stature are other than low IGF-I.
Title: Nutritional Status in Short Stature Children Is Related to Both Ghrelin and Insulin-like Growth Factor I Concentrations.
findings suggest that the Leu72Leu genotype may lead to increased risk of Alcohol Use Disorder possibly via mechanisms involving a lower response to alcohol resulting in excessive alcohol consumption.
Title: The Leu72Met Polymorphism of the Prepro-ghrelin Gene is Associated With Alcohol Consumption and Subjective Responses to Alcohol: Preliminary Findings.
Ghrelin is involved in appetite-regulating pathways during depression.
Title: Unstimulated and glucose-stimulated ghrelin in depressed patients and controls.

Submit: New GeneRIF Correction See all GeneRIFs (696)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Obesity MedGen: C0028754 OMIM: 601665 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from BioSystems

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Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
Circadian rythm related genes, organism-specific biosystemThis is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rh...
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
GPCR downstream signaling, organism-specific biosystem (from REACTOME)
GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
GPCR ligand binding, organism-specific biosystem (from REACTOME)
GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
Metabolism of proteins, organism-specific biosystem (from REACTOME)
Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
Peptide hormone metabolism, organism-specific biosystem (from REACTOME)
Peptide hormone metabolism, organism-specific biosystemPeptide hormones are cleaved from larger precursors in the secretory system (endoplasmic reticulum, Golgi apparatus, secretory granules) of the cell. After secretion peptide hormones are modified and...
Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
Signaling by GPCR, organism-specific biosystem (from REACTOME)
Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
Synthesis, secretion, and deacylation of Ghrelin, organism-specific biosystem (from REACTOME)
Synthesis, secretion, and deacylation of Ghrelin, organism-specific biosystemGhrelin is a peptide hormone of 28 amino acid residues which is acylated at the serine-3 of the mature peptide. Ghrelin is synthesized in several tissues: X/A-like cells of the gastric mucosa (the ma...
cAMP signaling pathway, organism-specific biosystem (from KEGG)
cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
cAMP signaling pathway, conserved biosystem (from KEGG)
cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G72347 (e-PCR)
- UniSTS:229910

G72348 (e-PCR)
- UniSTS:229911

G72349 (e-PCR)
- UniSTS:229912

G72355 (e-PCR)
- UniSTS:229506

RH36438 (e-PCR)
- UniSTS:80813

SHGC-34896 (e-PCR)
- UniSTS:6375

Homology

Homologs of the GHRL gene: The GHRL gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.
Orthologs from Annotation Pipeline: 154 organisms have orthologs with human gene GHRL
The Hierarchical Catalog of Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
G-protein coupled receptor binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
ghrelin receptor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
ghrelin receptor binding	ISS Inferred from Sequence or Structural Similarity more info
ghrelin receptor binding	TAS Traceable Author Statement more info	PubMed
growth hormone-releasing hormone activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
growth hormone-releasing hormone activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
growth hormone-releasing hormone activity	TAS Traceable Author Statement more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein tyrosine kinase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
G-protein coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
G-protein coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
actin polymerization or depolymerization	IDA Inferred from Direct Assay more info	PubMed
activation of MAPK activity	IMP Inferred from Mutant Phenotype more info	PubMed
adult feeding behavior	ISS Inferred from Sequence or Structural Similarity more info
cartilage development	NAS Non-traceable Author Statement more info	PubMed
cortisol secretion	NAS Non-traceable Author Statement more info	PubMed
decidualization	IDA Inferred from Direct Assay more info	PubMed
dendrite development	IDA Inferred from Direct Assay more info	PubMed
energy homeostasis	IEA Inferred from Electronic Annotation more info
excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
gastric acid secretion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
gastric emptying	IEA Inferred from Electronic Annotation more info
glucose metabolic process	NAS Non-traceable Author Statement more info	PubMed
growth hormone secretion	TAS Traceable Author Statement more info	PubMed
hormone-mediated signaling pathway	TAS Traceable Author Statement more info	PubMed
negative regulation of angiogenesis	NAS Non-traceable Author Statement more info	PubMed
negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of circadian sleep/wake cycle, REM sleep	IDA Inferred from Direct Assay more info	PubMed
negative regulation of endothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info	PubMed
negative regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
negative regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
negative regulation of interleukin-1 beta production	IDA Inferred from Direct Assay more info	PubMed
negative regulation of interleukin-6 biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of locomotion	IEA Inferred from Electronic Annotation more info
negative regulation of tumor necrosis factor biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of tumor necrosis factor secretion	IEA Inferred from Electronic Annotation more info
positive regulation of adipose tissue development	IEA Inferred from Electronic Annotation more info
positive regulation of appetite	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of bone development	IEA Inferred from Electronic Annotation more info
positive regulation of circadian sleep/wake cycle, non-REM sleep	IDA Inferred from Direct Assay more info	PubMed
positive regulation of corticotropin secretion	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cortisol secretion	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cytosolic calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of eating behavior	IEA Inferred from Electronic Annotation more info
positive regulation of gastric mucosal blood circulation	IEA Inferred from Electronic Annotation more info
positive regulation of growth hormone receptor signaling pathway	IC Inferred by Curator more info	PubMed
positive regulation of growth hormone secretion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of growth hormone secretion	IDA Inferred from Direct Assay more info	PubMed
positive regulation of growth rate	IEA Inferred from Electronic Annotation more info
positive regulation of insulin secretion	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of insulin secretion involved in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
positive regulation of multicellular organism growth	IC Inferred by Curator more info	PubMed
positive regulation of protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
positive regulation of small intestinal transit	IEA Inferred from Electronic Annotation more info
positive regulation of small intestine smooth muscle contraction	IEA Inferred from Electronic Annotation more info
positive regulation of sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
positive regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
positive regulation of vascular endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
regulation of cell proliferation	IDA Inferred from Direct Assay more info	PubMed
regulation of gastric motility	IEA Inferred from Electronic Annotation more info
regulation of response to food	IBA Inferred from Biological aspect of Ancestor more info	PubMed
regulation of signaling receptor activity	IEA Inferred from Electronic Annotation more info
regulation of transmission of nerve impulse	IEA Inferred from Electronic Annotation more info
response to electrical stimulus	IEA Inferred from Electronic Annotation more info
response to estrogen	IDA Inferred from Direct Assay more info	PubMed
response to hormone	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
axon	IDA Inferred from Direct Assay more info	PubMed
endoplasmic reticulum lumen	TAS Traceable Author Statement more info
extracellular region	IDA Inferred from Direct Assay more info	PubMed
extracellular region	TAS Traceable Author Statement more info
extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed
extracellular space	IDA Inferred from Direct Assay more info	PubMed
postsynapse	IEA Inferred from Electronic Annotation more info
secretory granule lumen	TAS Traceable Author Statement more info

General protein information

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Preferred Names: appetite-regulating hormone

Names: In2c-preproghrelin; ghrelin, growth hormone secretagogue receptor ligand; ghrelin/obestatin preprohormone; ghrelin/obestatin prepropeptide; growth hormone-releasing peptide; motilin-related peptide; prepro-appetite regulatory hormone; preproghrelin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_011560.1 RefSeqGene

Range

5001..12198

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001134941.2 → NP_001128413.1 appetite-regulating hormone isoform 2 preproprotein

See identical proteins and their annotated locations for NP_001128413.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting isoform (2) contains the ligands ghrelin-27, which lacks a single amino acid compared to ghrelin-28 found in isoform 1, and obestatin. Variants 2 and 10 encode the same protein.

Source sequence(s)

BC025791, EF549561, EF549563, EU072084, EU072085

Consensus CDS

CCDS46750.1

UniProtKB/Swiss-Prot

Q9UBU3

Related

ENSP00000287656.7, OTTHUMP00000207797, ENST00000287656.11, OTTHUMT00000339632

Conserved Domains (2) summary

pfam04643
Location:56 → 114

Motilin_assoc; Motilin/ghrelin-associated peptide

pfam04644
Location:25 → 50

Motilin_ghrelin; Motilin/ghrelin
NM_001134944.1 → NP_001128416.1 appetite-regulating hormone isoform 3

See identical proteins and their annotated locations for NP_001128416.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 5' coding region but maintains the reading frame, compared to variant 1. The resulting isoform (3) is shorter compared to isoform 1 and lacks the N-terminal region that encodes the signal peptide and ghrelin-28 ligand found in isoform 1.

Source sequence(s)

BC025791, EF549561, EF549574

Consensus CDS

CCDS46748.1

UniProtKB/Swiss-Prot

Q9UBU3

Related

ENSP00000416768.2, OTTHUMP00000207793, ENST00000437422.6, OTTHUMT00000339628

Conserved Domains (1) summary

pfam04643
Location:45 → 103

Motilin_assoc; Motilin/ghrelin-associated peptide
NM_001134945.1 → NP_001128417.1 appetite-regulating hormone isoform 4

See identical proteins and their annotated locations for NP_001128417.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks two alternate in-frame exons and uses an alternate in-frame splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. The resulting isoform (4) is shorter compared to isoform 1 and lacks the N-terminal region that encodes the signal peptide and ghrelin-28 ligand found in isoform 1.

Source sequence(s)

BC025791, EF549561, EU072086

Consensus CDS

CCDS46749.1

UniProtKB/Swiss-Prot

Q9UBU3

Related

ENSP00000388145.2, OTTHUMP00000207792, ENST00000449238.6, OTTHUMT00000339627

Conserved Domains (1) summary

pfam04643
Location:44 → 102

Motilin_assoc; Motilin/ghrelin-associated peptide
NM_001134946.1 → NP_001128418.1 appetite-regulating hormone isoform 5

See identical proteins and their annotated locations for NP_001128418.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks three alternate in-frame exons in the 5' coding region but maintains the reading frame, compared to variant 1. The resulting isoform (5) is shorter compared to isoform 1 and lacks the N-terminal region that encodes the signal peptide and ghrelin-28 ligand found in isoform 1.

Source sequence(s)

BC025791, EF549561, EF549575

Consensus CDS

CCDS46747.1

UniProtKB/Swiss-Prot

Q9UBU3

Related

ENSP00000403725.2, OTTHUMP00000226986, ENST00000439975.6, OTTHUMT00000379272

Conserved Domains (1) summary

pfam04643
Location:23 → 64

Motilin_assoc; Motilin/ghrelin-associated peptide
NM_001302821.1 → NP_001289750.1 appetite-regulating hormone isoform 1 preproprotein

See identical proteins and their annotated locations for NP_001289750.1

Status: REVIEWED

Description

Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. This isoform (8) contains the ligands ghrelin-28 and obestatin. Variants 1, 8, 9, 11 and 12 encode the same protein.

Source sequence(s)

AY359053, BC025791, EF549561, EU072084

Consensus CDS

CCDS33700.1

UniProtKB/Swiss-Prot

Q9UBU3

Conserved Domains (2) summary

pfam04643
Location:57 → 115

Motilin_assoc; Motilin/ghrelin-associated peptide

pfam04644
Location:25 → 51

Motilin_ghrelin; Motilin/ghrelin
NM_001302822.1 → NP_001289751.1 appetite-regulating hormone isoform 1 preproprotein

See identical proteins and their annotated locations for NP_001289751.1

Status: REVIEWED

Description

Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. This isoform (9) contains the ligands ghrelin-28 and obestatin. Variants 1, 8, 9, 11 and 12 encode the same protein.

Source sequence(s)

AY359053, BC025791, EF549561, EU072084

Consensus CDS

CCDS33700.1

UniProtKB/Swiss-Prot

Q9UBU3

Related

ENSP00000391406.1, OTTHUMP00000207798, ENST00000457360.5, OTTHUMT00000339633

Conserved Domains (2) summary

pfam04643
Location:57 → 115

Motilin_assoc; Motilin/ghrelin-associated peptide

pfam04644
Location:25 → 51

Motilin_ghrelin; Motilin/ghrelin
NM_001302823.1 → NP_001289752.1 appetite-regulating hormone isoform 2 preproprotein

See identical proteins and their annotated locations for NP_001289752.1

Status: REVIEWED

Description

Transcript Variant: This variant (10) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting isoform (2) contains the ligands ghrelin-27, which lacks a single amino acid compared to ghrelin-28 found in isoform 1, and obestatin. Variants 2 and 10 encode the same protein.

Source sequence(s)

BC025791, EF549561, EU072084

Consensus CDS

CCDS46750.1

UniProtKB/Swiss-Prot

Q9UBU3

Related

ENSP00000399922.1, OTTHUMP00000207795, ENST00000430179.5, OTTHUMT00000339630

Conserved Domains (2) summary

pfam04643
Location:56 → 114

Motilin_assoc; Motilin/ghrelin-associated peptide

pfam04644
Location:25 → 50

Motilin_ghrelin; Motilin/ghrelin
NM_001302824.1 → NP_001289753.1 appetite-regulating hormone isoform 1 preproprotein

See identical proteins and their annotated locations for NP_001289753.1

Status: REVIEWED

Description

Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 1. This isoform (11) contains the ligands ghrelin-28 and obestatin. Variants 1, 8, 9, 11 and 12 encode the same protein.

Source sequence(s)

AY359053, BC025791, EF549561, EU072084

Consensus CDS

CCDS33700.1

UniProtKB/Swiss-Prot

Q9UBU3

Related

ENSP00000414819.1, OTTHUMP00000207794, ENST00000429122.1, OTTHUMT00000339629

Conserved Domains (2) summary

pfam04643
Location:57 → 115

Motilin_assoc; Motilin/ghrelin-associated peptide

pfam04644
Location:25 → 51

Motilin_ghrelin; Motilin/ghrelin
NM_001302825.1 → NP_001289754.1 appetite-regulating hormone isoform 1 preproprotein

See identical proteins and their annotated locations for NP_001289754.1

Status: REVIEWED

Description

Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 1. This isoform (12) contains the ligands ghrelin-28 and obestatin. Variants 1, 8, 9, 11 and 12 encode the same protein.

Source sequence(s)

AY359053, BC025791, EF549561

Consensus CDS

CCDS33700.1

UniProtKB/Swiss-Prot

Q9UBU3

Conserved Domains (2) summary

pfam04643
Location:57 → 115

Motilin_assoc; Motilin/ghrelin-associated peptide

pfam04644
Location:25 → 51

Motilin_ghrelin; Motilin/ghrelin
NM_016362.4 → NP_057446.1 appetite-regulating hormone isoform 1 preproprotein

See identical proteins and their annotated locations for NP_057446.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). This isoform (1) contains the ligands ghrelin-28 and obestatin. Variants 1, 8, 9, 11 and 12 encode the same protein.

Source sequence(s)

AY359053, BC025791, EF549561, EF549563, EU072083, EU072084

Consensus CDS

CCDS33700.1

UniProtKB/Swiss-Prot

Q9UBU3

Related

ENSP00000335074.8, OTTHUMP00000207790, ENST00000335542.12, OTTHUMT00000339625

Conserved Domains (2) summary

pfam04643
Location:57 → 115

Motilin_assoc; Motilin/ghrelin-associated peptide

pfam04644
Location:25 → 51

Motilin_ghrelin; Motilin/ghrelin

RNA

NR_126505.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (13) lacks several alternate internal exons compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.

Source sequence(s)

BC025791, EF549557, EF549561

Related

ENST00000446937.2, OTTHUMT00000379273

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p12 Primary Assembly

Range

10285750..10292947 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024453594.1 → XP_024309362.1 appetite-regulating hormone isoform X1

Conserved Domains (2) summary

pfam04643
Location:57 → 115

Motilin_assoc; Motilin/ghrelin-associated peptide

pfam04644
Location:25 → 51

Motilin_ghrelin; Motilin/ghrelin
XM_017006613.2 → XP_016862102.1 appetite-regulating hormone isoform X2

UniProtKB/Swiss-Prot

Q9UBU3

Conserved Domains (2) summary

pfam04643
Location:56 → 114

Motilin_assoc; Motilin/ghrelin-associated peptide

pfam04644
Location:25 → 50

Motilin_ghrelin; Motilin/ghrelin
XM_017006612.2 → XP_016862101.1 appetite-regulating hormone isoform X1

UniProtKB/Swiss-Prot

Q9UBU3

Conserved Domains (2) summary

pfam04643
Location:57 → 115

Motilin_assoc; Motilin/ghrelin-associated peptide

pfam04644
Location:25 → 51

Motilin_ghrelin; Motilin/ghrelin