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TRMT6 tRNA methyltransferase 6 non-catalytic subunit [ Homo sapiens (human) ]

Gene ID: 51605, updated on 23-Nov-2021

Summary

Official Symbol
TRMT6provided by HGNC
Official Full Name
tRNA methyltransferase 6 non-catalytic subunitprovided by HGNC
Primary source
HGNC:HGNC:20900
See related
Ensembl:ENSG00000089195
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCD10; CGI-09; Gcd10p
Summary
This gene encodes a member of the tRNA methyltransferase 6 protein family. A similar protein in yeast is part of a two component methyltransferase, which is involved in the posttranslational modification that produces the modified nucleoside 1-methyladenosine in tRNAs. Modified 1-methyladenosine influences initiator methionine stability and may be involved in the replication of human immunodeficiency virus type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Ubiquitous expression in testis (RPKM 9.9), bone marrow (RPKM 9.2) and 25 other tissues See more
Orthologs
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Genomic context

See TRMT6 in Genome Data Viewer
Location:
20p12.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (5937228..5950533, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (5917874..5931179, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene chromogranin B Neighboring gene KN motif and ankyrin repeat domains 1 pseudogene 1 Neighboring gene minichromosome maintenance 8 homologous recombination repair factor Neighboring gene MCM8 antisense RNA 1 Neighboring gene RNA, 7SL, cytoplasmic 498, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide association studies identify loci associated with age at menarche and age at natural menopause.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of tRNA methyltransferase 6 homolog (TRMT6) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC5029

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in mRNA methylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tRNA methylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of tRNA (m1A) methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6
Names
mRNA methyladenosine-N(1)-methyltransferase non-catalytic subunit TRM6
tRNA methyltransferase 6 homolog
tRNA(m1A58)MTase subunit TRM6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281467.2NP_001268396.1  tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform 2

    See identical proteins and their annotated locations for NP_001268396.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AI291549, AK300812, AL035461, BC001262, DC348968
    Consensus CDS
    CCDS63225.1
    UniProtKB/Swiss-Prot
    Q9UJA5
    Related
    ENSP00000392070.2, ENST00000453074.6
    Conserved Domains (1) summary
    pfam04189
    Location:195
    Gcd10p; Gcd10p family
  2. NM_015939.5NP_057023.2  tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform 1

    See identical proteins and their annotated locations for NP_057023.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI291549, AL035461, BC001262, DC348968
    Consensus CDS
    CCDS13093.1
    UniProtKB/Swiss-Prot
    Q9UJA5
    Related
    ENSP00000203001.2, ENST00000203001.7
    Conserved Domains (1) summary
    pfam04189
    Location:19252
    Gcd10p; Gcd10p family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    5937228..5950533 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027875.1XP_016883364.1  tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform X1

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