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LARP7 La ribonucleoprotein 7, transcriptional regulator [ Homo sapiens (human) ]

Gene ID: 51574, updated on 9-Feb-2020

Summary

Official Symbol
LARP7provided by HGNC
Official Full Name
La ribonucleoprotein 7, transcriptional regulatorprovided by HGNC
Primary source
HGNC:HGNC:24912
See related
Ensembl:ENSG00000174720 MIM:612026
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALAZS; PIP7S; HDCMA18P
Summary
This gene encodes a protein which is found in the 7SK snRNP (small nuclear ribonucleoprotein). This snRNP complex inhibits a cyclin-dependent kinase, positive transcription elongation factor b, which is required for paused RNA polymerase II at a promoter to begin transcription elongation. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
Expression
Ubiquitous expression in lymph node (RPKM 17.7), thyroid (RPKM 16.5) and 25 other tissues See more
Orthologs

Genomic context

See LARP7 in Genome Data Viewer
Location:
4q25
Exon count:
17
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (112636964..112657592)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (113558120..113578748)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene NEUROG2 and ZGRF1 antisense RNA 1 Neighboring gene ribosomal protein L23a pseudogene 94 Neighboring gene zinc finger GRF-type containing 1 Neighboring gene H3 histone pseudogene 14 Neighboring gene miR-302/367 cluster host gene Neighboring gene microRNA 302d Neighboring gene microRNA 302a Neighboring gene microRNA 302c Neighboring gene microRNA 302b Neighboring gene microRNA 367 Neighboring gene oligosaccharyltransferase complex subunit pseudogene 4 Neighboring gene tryptophan rich basic protein pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat A La-related protein, LARP7, is associated with P-TEFb, HEXIM1/2, MEPCE, and 7SK RNA in a large stable complex form. Knockdown of LARP7 decreases the steady-state level of 7SK, but increases free P-TEFb and enhances Tat-mediated transcription PubMed
tat HIV-1 Tat forms at least two distinct P-TEFb-containing complexes. Tatcom1 is composed of P-TEFb, AF9, ENL, ELL, AFF1, AFF4, and PAF1, presenting strong CTD-kinase activity, while Tatcom2 consists of 7SK, LARP7, and MEPCE with two molecules of Tat/P-TEFb PubMed
tat HIV-1 Tat complexes with LARP7, MEPCE, SART3, NPM1, PPM1G, hnRNP-F, and 7SK RNA to form a Tat-7SK RNP complex to control HIV-1 transcription PubMed
tat CDK9-CycT1-AFF1 is stimulated by HIV-1 Tat and transferred as a single complex unit to BRD4 upon stress-induced disruption of AFF1-containing 7SK snRNP (HEXIM1, MEPCE, LARP7, 7SK RNA, CDK9, CycT1, and AFF1) PubMed
tat TAR binds Tat and P-TEFb as it emerges on the nascent transcript, competitively displacing the inhibitory 7SK snRNP (HEXIM1 and LARP7) and activating the P-TEFb kinase PubMed
tat HIV-1 Tat is identified to have a physical interaction with La ribonucleoprotein domain family, member 7 (LARP7) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC104360, DKFZp564K112

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
la-related protein 7
Names
La ribonucleoprotein domain family member 7
P-TEFb-interaction protein for 7SK stability

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032779.1 RefSeqGene

    Range
    5180..25623
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001267039.1NP_001253968.1  la-related protein 7 isoform 2

    See identical proteins and their annotated locations for NP_001253968.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longer protein (isoform 2).
    Source sequence(s)
    AC106864, BC066945
    Consensus CDS
    CCDS58924.1
    UniProtKB/Swiss-Prot
    Q4G0J3
    Related
    ENSP00000422626.1, ENST00000509061.5
    Conserved Domains (3) summary
    cd08032
    Location:37118
    LARP_7; La RNA-binding domain of La-related protein 7
    cd12290
    Location:133212
    RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
    pfam08777
    Location:461559
    RRM_3; RNA binding motif
  2. NM_001370974.1NP_001357903.1  la-related protein 7 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC106864
  3. NM_001370975.1NP_001357904.1  la-related protein 7 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC106864
  4. NM_001370976.1NP_001357905.1  la-related protein 7 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC106864
  5. NM_001370977.1NP_001357906.1  la-related protein 7 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC106864
  6. NM_001370978.1NP_001357907.1  la-related protein 7 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC106864
    Related
    ENSP00000499190.1, ENST00000651579.1
  7. NM_001370979.1NP_001357908.1  la-related protein 7 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC106864
  8. NM_001370980.1NP_001357909.1  la-related protein 7 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC106864
  9. NM_001370981.1NP_001357910.1  la-related protein 7 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC106864
  10. NM_001370982.1NP_001357911.1  la-related protein 7 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC106864
  11. NM_015454.2NP_056269.1  la-related protein 7 isoform 1

    See identical proteins and their annotated locations for NP_056269.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks a 5' exon compared to variant 3. These differences cause translation initiation at a downstream AUG and result in a protein (isoform 1) with a shorter N-terminus compared to isoform 2. Variants 1, 2, and 9 encode the same protein (isoform 1).
    Source sequence(s)
    AI652351, AL049996, BM979591, CA314598, CN346208
    Consensus CDS
    CCDS3701.2
    UniProtKB/Swiss-Prot
    Q4G0J3
    Related
    ENSP00000314311.6, ENST00000324052.10
    Conserved Domains (4) summary
    cd08032
    Location:30111
    LARP_7; La RNA-binding domain of La-related protein 7
    COG0724
    Location:117300
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12290
    Location:126205
    RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
    pfam08777
    Location:454552
    RRM_3; RNA binding motif
  12. NM_016648.4NP_057732.2  la-related protein 7 isoform 1

    See identical proteins and their annotated locations for NP_057732.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks two 5' exons compared to variant 3. These differences cause translation initiation at a downstream AUG and result in a protein (isoform 1) with a shorter N-terminus compared to isoform 2. Variants 1, 2, and 9 encode the same protein (isoform 1).
    Source sequence(s)
    AC106864, AK000274, AL049996, DB270203
    Consensus CDS
    CCDS3701.2
    UniProtKB/Swiss-Prot
    Q4G0J3
    Related
    ENSP00000344950.5, ENST00000344442.10
    Conserved Domains (4) summary
    cd08032
    Location:30111
    LARP_7; La RNA-binding domain of La-related protein 7
    COG0724
    Location:117300
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12290
    Location:126205
    RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
    pfam08777
    Location:454552
    RRM_3; RNA binding motif

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    112636964..112657592
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024454082.1XP_024309850.1  la-related protein 7 isoform X1

    Conserved Domains (4) summary
    cd08032
    Location:30111
    LARP_7; La RNA-binding domain of La-related protein 7
    COG0724
    Location:117300
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12290
    Location:126205
    RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
    pfam08777
    Location:467565
    RRM_3; RNA binding motif
  2. XM_024454084.1XP_024309852.1  la-related protein 7 isoform X2

    Conserved Domains (4) summary
    cd08032
    Location:30111
    LARP_7; La RNA-binding domain of La-related protein 7
    COG0724
    Location:117300
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12290
    Location:126205
    RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
    pfam08777
    Location:454552
    RRM_3; RNA binding motif
  3. XM_024454083.1XP_024309851.1  la-related protein 7 isoform X1

    Conserved Domains (4) summary
    cd08032
    Location:30111
    LARP_7; La RNA-binding domain of La-related protein 7
    COG0724
    Location:117300
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12290
    Location:126205
    RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
    pfam08777
    Location:467565
    RRM_3; RNA binding motif
  4. XM_024454086.1XP_024309854.1  la-related protein 7 isoform X3

    Conserved Domains (4) summary
    COG0724
    Location:38221
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12290
    Location:47126
    RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
    pfam08777
    Location:388486
    RRM_3; RNA binding motif
    cl02755
    Location:132
    LAM; LA motif RNA-binding domain
  5. XM_024454089.1XP_024309857.1  la-related protein 7 isoform X5

    Related
    ENSP00000426376.1, ENST00000511529.1
    Conserved Domains (1) summary
    pfam08777
    Location:240338
    RRM_3; RNA binding motif
  6. XM_024454087.1XP_024309855.1  la-related protein 7 isoform X3

    Conserved Domains (4) summary
    COG0724
    Location:38221
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12290
    Location:47126
    RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
    pfam08777
    Location:388486
    RRM_3; RNA binding motif
    cl02755
    Location:132
    LAM; LA motif RNA-binding domain
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