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LARP7 La ribonucleoprotein 7, transcriptional regulator [ Homo sapiens (human) ]

Gene ID: 51574, updated on 3-Dec-2024

Summary

Official Symbol
LARP7provided by HGNC
Official Full Name
La ribonucleoprotein 7, transcriptional regulatorprovided by HGNC
Primary source
HGNC:HGNC:24912
See related
Ensembl:ENSG00000174720 MIM:612026; AllianceGenome:HGNC:24912
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALAZS; PIP7S; hLARP7; HDCMA18P
Summary
This gene encodes a protein which is found in the 7SK snRNP (small nuclear ribonucleoprotein). This snRNP complex inhibits a cyclin-dependent kinase, positive transcription elongation factor b, which is required for paused RNA polymerase II at a promoter to begin transcription elongation. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
Expression
Ubiquitous expression in lymph node (RPKM 17.7), thyroid (RPKM 16.5) and 25 other tissues See more
Orthologs
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Genomic context

See LARP7 in Genome Data Viewer
Location:
4q25
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (112637143..112657586)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (115945482..115965926)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (113558299..113578742)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene NEUROG2 and ZGRF1 antisense RNA 1 Neighboring gene ribosomal protein L23a pseudogene 94 Neighboring gene zinc finger GRF-type containing 1 Neighboring gene H3 histone pseudogene 14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21831 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21832 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21833 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:113564861-113564962 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:113570027-113570749 Neighboring gene miR-302/367 cluster host gene Neighboring gene microRNA 302d Neighboring gene microRNA 302a Neighboring gene microRNA 302c Neighboring gene microRNA 302b Neighboring gene microRNA 367 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:113604501-113604662 Neighboring gene oligosaccharyltransferase complex subunit pseudogene 4 Neighboring gene GET1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat A La-related protein, LARP7, is associated with P-TEFb, HEXIM1/2, MEPCE, and 7SK RNA in a large stable complex form. Knockdown of LARP7 decreases the steady-state level of 7SK, but increases free P-TEFb and enhances Tat-mediated transcription PubMed
tat HIV-1 Tat forms at least two distinct P-TEFb-containing complexes. Tatcom1 is composed of P-TEFb, AF9, ENL, ELL, AFF1, AFF4, and PAF1, presenting strong CTD-kinase activity, while Tatcom2 consists of 7SK, LARP7, and MEPCE with two molecules of Tat/P-TEFb PubMed
tat HIV-1 Tat complexes with LARP7, MEPCE, SART3, NPM1, PPM1G, hnRNP-F, and 7SK RNA to form a Tat-7SK RNP complex to control HIV-1 transcription PubMed
tat CDK9-CycT1-AFF1 is stimulated by HIV-1 Tat and transferred as a single complex unit to BRD4 upon stress-induced disruption of AFF1-containing 7SK snRNP (HEXIM1, MEPCE, LARP7, 7SK RNA, CDK9, CycT1, and AFF1) PubMed
tat TAR binds Tat and P-TEFb as it emerges on the nascent transcript, competitively displacing the inhibitory 7SK snRNP (HEXIM1 and LARP7) and activating the P-TEFb kinase PubMed
tat HIV-1 Tat is identified to have a physical interaction with La ribonucleoprotein domain family, member 7 (LARP7) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC104360, DKFZp564K112

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 7SK snRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables U6 snRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of 7SK snRNP IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
la-related protein 7
Names
La ribonucleoprotein domain family member 7
P-TEFb-interaction protein for 7SK stability

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032779.1 RefSeqGene

    Range
    5180..25623
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001267039.4NP_001253968.2  la-related protein 7 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 2, 3 and 9 encode the same isoform (1).
    Source sequence(s)
    AC106864
    Consensus CDS
    CCDS3701.2
    UniProtKB/Swiss-Prot
    B2ZHN6, Q3B7A9, Q4G0J3, Q9P1S7, Q9Y3Z8
    UniProtKB/TrEMBL
    A0A8Q3SHF1
    Related
    ENSP00000422626.2, ENST00000509061.5
    Conserved Domains (4) summary
    cd08032
    Location:30111
    LARP_7; La RNA-binding domain of La-related protein 7
    COG0724
    Location:117300
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12290
    Location:126205
    RRM1_LARP7; RNA recognition motif 1 (RRM1) found in La-related protein 7 (LARP7) and similar proteins
    cd12542
    Location:454535
    RRM2_LARP7; RNA recognition motif 2 in La-related protein 7 (LARP7) and similar proteins
  2. NM_001370974.1NP_001357903.1  la-related protein 7 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC106864
    Consensus CDS
    CCDS93568.1
    UniProtKB/TrEMBL
    A0A8Q3SHG9, A0A8Q3SHN7
    Conserved Domains (4) summary
    cd08032
    Location:30111
    LARP_7; La RNA-binding domain of La-related protein 7
    COG0724
    Location:117300
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12290
    Location:126205
    RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
    pfam08777
    Location:467565
    RRM_3; RNA binding motif
  3. NM_001370975.1NP_001357904.1  la-related protein 7 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC106864
    Consensus CDS
    CCDS93568.1
    UniProtKB/TrEMBL
    A0A8Q3SHG9, A0A8Q3SHN7
    Related
    ENSP00000511576.1, ENST00000694898.1
    Conserved Domains (4) summary
    cd08032
    Location:30111
    LARP_7; La RNA-binding domain of La-related protein 7
    COG0724
    Location:117300
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12290
    Location:126205
    RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
    pfam08777
    Location:467565
    RRM_3; RNA binding motif
  4. NM_001370976.1NP_001357905.1  la-related protein 7 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC106864
    Consensus CDS
    CCDS93569.1
    UniProtKB/TrEMBL
    A0A8Q3SHG9, H0YA82
    Related
    ENSP00000426376.2, ENST00000511529.2
    Conserved Domains (4) summary
    cd08032
    Location:30111
    LARP_7; La RNA-binding domain of La-related protein 7
    COG0724
    Location:117299
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12290
    Location:126205
    RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
    pfam08777
    Location:466564
    RRM_3; RNA binding motif
  5. NM_001370977.1NP_001357906.1  la-related protein 7 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC106864
    Consensus CDS
    CCDS93569.1
    UniProtKB/TrEMBL
    A0A8Q3SHG9, H0YA82
    Conserved Domains (4) summary
    cd08032
    Location:30111
    LARP_7; La RNA-binding domain of La-related protein 7
    COG0724
    Location:117299
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12290
    Location:126205
    RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
    pfam08777
    Location:466564
    RRM_3; RNA binding motif
  6. NM_001370978.1NP_001357907.1  la-related protein 7 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC106864
    Consensus CDS
    CCDS3701.2
    UniProtKB/Swiss-Prot
    B2ZHN6, Q3B7A9, Q4G0J3, Q9P1S7, Q9Y3Z8
    UniProtKB/TrEMBL
    A0A8Q3SHF1
    Related
    ENSP00000499190.1, ENST00000651579.1
    Conserved Domains (4) summary
    cd08032
    Location:30111
    LARP_7; La RNA-binding domain of La-related protein 7
    COG0724
    Location:117300
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12290
    Location:126205
    RRM1_LARP7; RNA recognition motif 1 (RRM1) found in La-related protein 7 (LARP7) and similar proteins
    cd12542
    Location:454535
    RRM2_LARP7; RNA recognition motif 2 in La-related protein 7 (LARP7) and similar proteins
  7. NM_001370979.1NP_001357908.1  la-related protein 7 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC106864
    Consensus CDS
    CCDS93570.1
    UniProtKB/TrEMBL
    A0A8Q3SHF1, A0A8Q3SHH4
    Related
    ENSP00000511571.1, ENST00000694891.1
    Conserved Domains (4) summary
    cd08032
    Location:30111
    LARP_7; La RNA-binding domain of La-related protein 7
    COG0724
    Location:117299
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12290
    Location:126205
    RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
    pfam08777
    Location:453551
    RRM_3; RNA binding motif
  8. NM_001370980.1NP_001357909.1  la-related protein 7 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC106864
    Consensus CDS
    CCDS93570.1
    UniProtKB/TrEMBL
    A0A8Q3SHF1, A0A8Q3SHH4
    Related
    ENSP00000511577.1, ENST00000694899.1
    Conserved Domains (4) summary
    cd08032
    Location:30111
    LARP_7; La RNA-binding domain of La-related protein 7
    COG0724
    Location:117299
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12290
    Location:126205
    RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
    pfam08777
    Location:453551
    RRM_3; RNA binding motif
  9. NM_001370981.1NP_001357910.1  la-related protein 7 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC106864
    Consensus CDS
    CCDS93571.1
    UniProtKB/TrEMBL
    A0A8I5KUI4, A0A8Q3SHF1
    Related
    ENSP00000508585.1, ENST00000693375.1
    Conserved Domains (4) summary
    COG0724
    Location:38221
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12290
    Location:47126
    RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
    pfam08777
    Location:375473
    RRM_3; RNA binding motif
    cl02755
    Location:132
    LAM; LA motif RNA-binding domain
  10. NM_001370982.1NP_001357911.1  la-related protein 7 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC106864
    Consensus CDS
    CCDS93571.1
    UniProtKB/TrEMBL
    A0A8I5KUI4, A0A8Q3SHF1
    Related
    ENSP00000509527.1, ENST00000692416.1
    Conserved Domains (4) summary
    COG0724
    Location:38221
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12290
    Location:47126
    RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
    pfam08777
    Location:375473
    RRM_3; RNA binding motif
    cl02755
    Location:132
    LAM; LA motif RNA-binding domain
  11. NM_015454.3NP_056269.1  la-related protein 7 isoform 1

    See identical proteins and their annotated locations for NP_056269.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks a 5' exon compared to variant 3. These differences cause translation initiation at a downstream AUG and result in a protein (isoform 1) with a shorter N-terminus compared to isoform 2. Variants 1, 2, and 9 encode the same protein (isoform 1).
    Source sequence(s)
    AL049996, BM979591, CA314598, CN346208
    Consensus CDS
    CCDS3701.2
    UniProtKB/Swiss-Prot
    B2ZHN6, Q3B7A9, Q4G0J3, Q9P1S7, Q9Y3Z8
    UniProtKB/TrEMBL
    A0A8Q3SHF1
    Related
    ENSP00000421541.2, ENST00000505034.6
    Conserved Domains (4) summary
    cd08032
    Location:30111
    LARP_7; La RNA-binding domain of La-related protein 7
    COG0724
    Location:117300
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12290
    Location:126205
    RRM1_LARP7; RNA recognition motif 1 (RRM1) found in La-related protein 7 (LARP7) and similar proteins
    cd12542
    Location:454535
    RRM2_LARP7; RNA recognition motif 2 in La-related protein 7 (LARP7) and similar proteins
  12. NM_016648.4NP_057732.2  la-related protein 7 isoform 1

    See identical proteins and their annotated locations for NP_057732.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks two 5' exons compared to variant 3. These differences cause translation initiation at a downstream AUG and result in a protein (isoform 1) with a shorter N-terminus compared to isoform 2. Variants 1, 2, and 9 encode the same protein (isoform 1).
    Source sequence(s)
    AC106864, AK000274, AL049996, DB270203
    Consensus CDS
    CCDS3701.2
    UniProtKB/Swiss-Prot
    B2ZHN6, Q3B7A9, Q4G0J3, Q9P1S7, Q9Y3Z8
    UniProtKB/TrEMBL
    A0A8Q3SHF1
    Related
    ENSP00000344950.5, ENST00000344442.10
    Conserved Domains (4) summary
    cd08032
    Location:30111
    LARP_7; La RNA-binding domain of La-related protein 7
    COG0724
    Location:117300
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12290
    Location:126205
    RRM1_LARP7; RNA recognition motif 1 (RRM1) found in La-related protein 7 (LARP7) and similar proteins
    cd12542
    Location:454535
    RRM2_LARP7; RNA recognition motif 2 in La-related protein 7 (LARP7) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    112637143..112657586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047415769.1XP_047271725.1  la-related protein 7 isoform X1

    UniProtKB/TrEMBL
    A0A8Q3SHG9, A0A8Q3SHN7
  2. XM_047415771.1XP_047271727.1  la-related protein 7 isoform X2

    UniProtKB/Swiss-Prot
    B2ZHN6, Q3B7A9, Q4G0J3, Q9P1S7, Q9Y3Z8
    UniProtKB/TrEMBL
    A0A8Q3SHF1
  3. XM_024454083.2XP_024309851.1  la-related protein 7 isoform X1

    UniProtKB/TrEMBL
    A0A8Q3SHG9, A0A8Q3SHN7
    Conserved Domains (4) summary
    cd08032
    Location:30111
    LARP_7; La RNA-binding domain of La-related protein 7
    COG0724
    Location:117300
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12290
    Location:126205
    RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
    pfam08777
    Location:467565
    RRM_3; RNA binding motif
  4. XM_047415770.1XP_047271726.1  la-related protein 7 isoform X2

    UniProtKB/Swiss-Prot
    B2ZHN6, Q3B7A9, Q4G0J3, Q9P1S7, Q9Y3Z8
    UniProtKB/TrEMBL
    A0A8Q3SHF1
  5. XM_047415768.1XP_047271724.1  la-related protein 7 isoform X1

    UniProtKB/TrEMBL
    A0A8Q3SHG9, A0A8Q3SHN7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    115945482..115965926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350164.1XP_054206139.1  la-related protein 7 isoform X1

    UniProtKB/TrEMBL
    A0A8Q3SHG9, A0A8Q3SHN7
  2. XM_054350166.1XP_054206141.1  la-related protein 7 isoform X2

    UniProtKB/Swiss-Prot
    B2ZHN6, Q3B7A9, Q4G0J3, Q9P1S7, Q9Y3Z8
    UniProtKB/TrEMBL
    A0A8Q3SHF1
  3. XM_054350162.1XP_054206137.1  la-related protein 7 isoform X1

    UniProtKB/TrEMBL
    A0A8Q3SHG9, A0A8Q3SHN7
  4. XM_054350165.1XP_054206140.1  la-related protein 7 isoform X2

    UniProtKB/Swiss-Prot
    B2ZHN6, Q3B7A9, Q4G0J3, Q9P1S7, Q9Y3Z8
    UniProtKB/TrEMBL
    A0A8Q3SHF1
  5. XM_054350163.1XP_054206138.1  la-related protein 7 isoform X1

    UniProtKB/TrEMBL
    A0A8Q3SHG9, A0A8Q3SHN7