U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZNF581 zinc finger protein 581 [ Homo sapiens (human) ]

Gene ID: 51545, updated on 6-Sep-2022

Summary

Official Symbol
ZNF581provided by HGNC
Official Full Name
zinc finger protein 581provided by HGNC
Primary source
HGNC:HGNC:25017
See related
Ensembl:ENSG00000171425 AllianceGenome:HGNC:25017
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSPC189
Summary
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 7.6), spleen (RPKM 6.6) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ZNF581 in Genome Data Viewer
Location:
19q13.42
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (55635003..55645623)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (58739564..58741538)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (56155015..56156989)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 865 Neighboring gene zinc finger protein 784 Neighboring gene uncharacterized LOC107983998 Neighboring gene zinc finger protein 580 Neighboring gene coiled-coil domain containing 106 Neighboring gene U2 small nuclear RNA auxiliary factor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22550

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016535.4NP_057619.1  zinc finger protein 581

    See identical proteins and their annotated locations for NP_057619.1

    Status: VALIDATED

    Source sequence(s)
    AF151023, BC010097
    Consensus CDS
    CCDS12932.1
    UniProtKB/Swiss-Prot
    B2RDM6, Q9P0T4
    Related
    ENSP00000270451.4, ENST00000270451.6
    Conserved Domains (2) summary
    sd00017
    Location:117137
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:101126
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    55635003..55645623
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026867.2XP_016882356.1  zinc finger protein 581 isoform X1

    UniProtKB/Swiss-Prot
    B2RDM6, Q9P0T4
    Related
    ENSP00000466564.1, ENST00000588537.1
    Conserved Domains (2) summary
    sd00017
    Location:117137
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:101126
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    58739564..58741538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)