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SCLY selenocysteine lyase [ Homo sapiens (human) ]

Gene ID: 51540, updated on 1-Jun-2020

Summary

Official Symbol
SCLYprovided by HGNC
Official Full Name
selenocysteine lyaseprovided by HGNC
Primary source
HGNC:HGNC:18161
See related
Ensembl:ENSG00000132330 MIM:611056
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCL; hSCL
Summary
Selenocysteine lyase (SCLY; EC 4.4.1.16) catalyzes the pyridoxal 5-prime phosphate-dependent conversion of L-selenocysteine to L-alanine and elemental selenium (Mihara et al., 2000 [PubMed 10692412]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in kidney (RPKM 6.4), liver (RPKM 4.7) and 25 other tissues See more
Orthologs

Genomic context

See SCLY in Genome Data Viewer
Location:
2q37.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (238061001..238099413)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (238969565..239008054)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr2.7219 Neighboring gene UBE2F-SCLY readthrough (NMD candidate) Neighboring gene ubiquitin conjugating enzyme E2 F (putative) Neighboring gene RNA, U6 small nuclear 1333, pseudogene Neighboring gene Sharpr-MPRA regulatory region 4740 Neighboring gene espin like Neighboring gene kelch like family member 30

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough UBE2F-SCLY

Readthrough gene: UBE2F-SCLY, Included gene: UBE2F

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
selenocysteine lyase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular amino acid metabolic process TAS
Traceable Author Statement
more info
PubMed 
selenium compound metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
selenocysteine lyase
NP_057594.5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016510.7NP_057594.5  selenocysteine lyase

    Status: VALIDATED

    Source sequence(s)
    AB209458, AC016757, AK293283, BC007891, BC018966
    Consensus CDS
    CCDS2524.2
    Related
    ENSP00000254663.7, ENST00000254663.12
    Conserved Domains (1) summary
    COG1104
    Location:30441
    NifS; Cysteine sulfinate desulfinase/cysteine desulfurase or related enzyme [Amino acid transport and metabolism]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    238061001..238099413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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