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UBE2F ubiquitin conjugating enzyme E2 F (putative) [ Homo sapiens (human) ]

Gene ID: 140739, updated on 7-Jun-2020

Summary

Official Symbol
UBE2Fprovided by HGNC
Official Full Name
ubiquitin conjugating enzyme E2 F (putative)provided by HGNC
Primary source
HGNC:HGNC:12480
See related
Ensembl:ENSG00000184182 MIM:617700
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCE2
Expression
Ubiquitous expression in bone marrow (RPKM 11.8), thyroid (RPKM 10.6) and 25 other tissues See more
Orthologs

Genomic context

See UBE2F in Genome Data Viewer
Location:
2q37.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (237966945..238042782)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (238875587..238951423)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr2.7218 Neighboring gene CRISPRi-validated cis-regulatory element chr2.7219 Neighboring gene UBE2F-SCLY readthrough (NMD candidate) Neighboring gene RNA, U6 small nuclear 1333, pseudogene Neighboring gene selenocysteine lyase Neighboring gene Sharpr-MPRA regulatory region 4740 Neighboring gene espin like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif The conjugation of NEDD8 to Cullin-5 by UBE2F is required for HIV-1 Vif-mediated A3G degradation PubMed
vif The active site proximal loop extension (residues 124-129) in UBE2F is critical for HIV-1 Vif-mediated A3G degradation PubMed
vif UBE2F and RBX2 are required for activation of the polyubiquitin synthesis activity of Vif/CBF-beta/CUL5, leading to HIV-1 Vif-mediated degradation of A3G in cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC18120

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
NEDD8 conjugating enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
NEDD8 transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NEDD8 transferase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein neddylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein neddylation IDA
Inferred from Direct Assay
more info
PubMed 
protein neddylation IEA
Inferred from Electronic Annotation
more info
 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
NEDD8-conjugating enzyme UBE2F
Names
NEDD8 carrier protein UBE2F
NEDD8 protein ligase UBE2F
NEDD8-conjugating enzyme 2
RING-type E3 NEDD8 transferase UBE2F
ubiquitin-conjugating enzyme E2F (putative)
NP_001265234.1
NP_001265235.1
NP_001265236.1
NP_001265237.1
NP_542409.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278305.1NP_001265234.1  NEDD8-conjugating enzyme UBE2F isoform 1

    See identical proteins and their annotated locations for NP_001265234.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK294107, CN370973, CN370974, DA140546, DB118122
    Consensus CDS
    CCDS2523.1
    UniProtKB/Swiss-Prot
    Q969M7
    Related
    ENSP00000478474.1, ENST00000612130.4
    Conserved Domains (1) summary
    cl00154
    Location:30184
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  2. NM_001278306.1NP_001265235.1  NEDD8-conjugating enzyme UBE2F isoform 2

    See identical proteins and their annotated locations for NP_001265235.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1 and has a distinct N-terminus.
    Source sequence(s)
    AK294107, BM470609, BX421077, CN370973, CN370974
    Consensus CDS
    CCDS63175.1
    UniProtKB/Swiss-Prot
    Q969M7
    Related
    ENSP00000386680.1, ENST00000409953.5
    Conserved Domains (1) summary
    COG5078
    Location:16160
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
  3. NM_001278307.1NP_001265236.1  NEDD8-conjugating enzyme UBE2F isoform 3

    See identical proteins and their annotated locations for NP_001265236.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AK297502, BX421077, CN370973, CN370974
    Consensus CDS
    CCDS63177.1
    UniProtKB/Swiss-Prot
    Q969M7
    Related
    ENSP00000399183.1, ENST00000414443.5
    Conserved Domains (1) summary
    COG5078
    Location:40152
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
  4. NM_001278308.1NP_001265237.1  NEDD8-conjugating enzyme UBE2F isoform 4

    See identical proteins and their annotated locations for NP_001265237.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AK294107, BQ959565, BX421077, CN370973, CN370974
    Consensus CDS
    CCDS63176.1
    UniProtKB/Swiss-Prot
    Q969M7
    Related
    ENSP00000387299.1, ENST00000409633.5
    Conserved Domains (1) summary
    cd00195
    Location:35149
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  5. NM_080678.3NP_542409.1  NEDD8-conjugating enzyme UBE2F isoform 1

    See identical proteins and their annotated locations for NP_542409.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK290063, AK294107, BC010549, BX421077, CN370973
    Consensus CDS
    CCDS2523.1
    UniProtKB/Swiss-Prot
    Q969M7
    Related
    ENSP00000272930.4, ENST00000272930.8
    Conserved Domains (1) summary
    cl00154
    Location:30184
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RNA

  1. NR_103498.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK294107, BX421077, CN370973, CN370974
  2. NR_103499.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK303094, BQ959565, BX421077, CN370973, CN370974
  3. NR_103500.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK294107, BM920749, BX421077, CN370973, CN370974

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    237966945..238042782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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