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UFC1 ubiquitin-fold modifier conjugating enzyme 1 [ Homo sapiens (human) ]

Gene ID: 51506, updated on 24-Nov-2020

Summary

Official Symbol
UFC1provided by HGNC
Official Full Name
ubiquitin-fold modifier conjugating enzyme 1provided by HGNC
Primary source
HGNC:HGNC:26941
See related
Ensembl:ENSG00000143222 MIM:610554
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NEDSG; HSPC155
Summary
UFC1 is an E2-like conjugating enzyme for ubiquitin-fold modifier-1 (UFM1; MIM 610553) (Komatsu et al., 2004 [PubMed 15071506]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in urinary bladder (RPKM 37.2), ovary (RPKM 36.8) and 25 other tissues See more
Orthologs

Genomic context

See UFC1 in Genome Data Viewer
Location:
1q23.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (161132703..161158856)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161123534..161128646)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene prefoldin subunit 2 Neighboring gene nitrilase 1 Neighboring gene death effector domain containing Neighboring gene linc-UFC1 Neighboring gene ubiquitin specific peptidase 21 Neighboring gene protoporphyrinogen oxidase Neighboring gene beta-1,4-galactosyltransferase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
UFM1 conjugating enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
UFM1 transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein K69-linked ufmylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K69-linked ufmylation IDA
Inferred from Direct Assay
more info
PubMed 
protein ufmylation IDA
Inferred from Direct Assay
more info
PubMed 
protein ufmylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
reticulophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 

General protein information

Preferred Names
ubiquitin-fold modifier-conjugating enzyme 1
Names
Ufm1-conjugating enzyme 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016406.4NP_057490.2  ubiquitin-fold modifier-conjugating enzyme 1

    See identical proteins and their annotated locations for NP_057490.2

    Status: VALIDATED

    Source sequence(s)
    AF151884
    Consensus CDS
    CCDS1220.1
    UniProtKB/Swiss-Prot
    Q9Y3C8
    Related
    ENSP00000356982.5, ENST00000368003.6
    Conserved Domains (1) summary
    pfam08694
    Location:6160
    UFC1; Ubiquitin-fold modifier-conjugating enzyme 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    161132703..161158856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001450.2XP_016856939.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y3C8
    Conserved Domains (1) summary
    pfam08694
    Location:6160
    UFC1; Ubiquitin-fold modifier-conjugating enzyme 1
  2. XM_017001451.1XP_016856940.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y3C8
    Conserved Domains (1) summary
    pfam08694
    Location:6160
    UFC1; Ubiquitin-fold modifier-conjugating enzyme 1
  3. XM_005245254.1XP_005245311.1  ubiquitin-fold modifier-conjugating enzyme 1 isoform X2

    See identical proteins and their annotated locations for XP_005245311.1

    Conserved Domains (1) summary
    pfam08694
    Location:6110
    UFC1; Ubiquitin-fold modifier-conjugating enzyme 1
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