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UBE2J1 ubiquitin conjugating enzyme E2 J1 [ Homo sapiens (human) ]

Gene ID: 51465, updated on 13-Mar-2020

Summary

Official Symbol
UBE2J1provided by HGNC
Official Full Name
ubiquitin conjugating enzyme E2 J1provided by HGNC
Primary source
HGNC:HGNC:17598
See related
Ensembl:ENSG00000198833 MIM:616175
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UBC6; UBC6E; Ubc6p; CGI-76; NCUBE1; HSPC153; HSPC205; NCUBE-1; HSU93243
Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 49.6), bone marrow (RPKM 46.1) and 25 other tissues See more
Orthologs

Genomic context

See UBE2J1 in Genome Data Viewer
Location:
6q15
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (89326625..89353155, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (90036344..90062619, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid type A receptor subunit rho1 Neighboring gene gamma-aminobutyric acid type A receptor subunit rho2 Neighboring gene tubulin beta 3 class III pseudogene 1 Neighboring gene Ras related GTP binding D Neighboring gene NACA pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC12555

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin conjugating enzyme activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of retrograde protein transport, ER to cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein N-linked glycosylation via asparagine IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of tumor necrosis factor biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
spermatid development IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent ERAD pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2 J1
Names
E2 ubiquitin-conjugating enzyme J1
HSUBC6e
non-canonical ubiquitin-conjugating enzyme 1
ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)
ubiquitin-conjugating enzyme E2, J1, U
yeast ubiquitin-conjugating enzyme UBC6 homolog E
NP_057105.2
XP_011534189.1
XP_011534190.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016021.3NP_057105.2  ubiquitin-conjugating enzyme E2 J1

    See identical proteins and their annotated locations for NP_057105.2

    Status: REVIEWED

    Source sequence(s)
    AF151834, AJ420522, AJ420578, BC013973
    Consensus CDS
    CCDS5021.1
    UniProtKB/Swiss-Prot
    Q9Y385
    Related
    ENSP00000451261.1, ENST00000435041.3
    Conserved Domains (1) summary
    cd00195
    Location:12119
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    89326625..89353155 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535887.2XP_011534189.1  ubiquitin-conjugating enzyme E2 J1 isoform X1

    Conserved Domains (1) summary
    cd00195
    Location:12119
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  2. XM_011535888.3XP_011534190.1  ubiquitin-conjugating enzyme E2 J1 isoform X2

    Conserved Domains (1) summary
    cd00195
    Location:12119
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
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