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Ube2j1 ubiquitin-conjugating enzyme E2J 1 [ Mus musculus (house mouse) ]

Gene ID: 56228, updated on 8-Jan-2023

Summary

Official Symbol
Ube2j1provided by MGI
Official Full Name
ubiquitin-conjugating enzyme E2J 1provided by MGI
Primary source
MGI:MGI:1926245
See related
Ensembl:ENSMUSG00000028277 AllianceGenome:MGI:1926245
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ncube; Ubc6p; Ncube1; NCUBE-1; 0710008M05Rik; 1110030I22Rik
Summary
Predicted to enable ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Acts upstream of or within regulation of tumor necrosis factor production; spermatid development; and ubiquitin-dependent ERAD pathway. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; nervous system; reproductive system; sensory organ; and skeleton. Orthologous to human UBE2J1 (ubiquitin conjugating enzyme E2 J1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 89.0), cerebellum adult (RPKM 20.0) and 27 other tissues See more
Orthologs
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Genomic context

See Ube2j1 in Genome Data Viewer
Location:
4; 4 A5
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (33031380..33052367)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (33031380..33052367)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene Ras-related GTP binding D Neighboring gene RIKEN cDNA 4933421O10 gene Neighboring gene basic transcription factor 3, pseudogene 8 Neighboring gene gamma-aminobutyric acid (GABA) C receptor, subunit rho 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin conjugating enzyme activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2 J1
Names
E2 ubiquitin-conjugating enzyme J1
non-canonical ubiquitin-conjugating enzyme 1
ubiquitin-conjugating enzyme E2, J1
NP_001342423.1
NP_062532.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355494.1NP_001342423.1  ubiquitin-conjugating enzyme E2 J1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region. The encoded isoform (2) has the same N- and C-termini, but is shorter than isoform 1.
    Source sequence(s)
    AK149985, AL670464, AL772288, AW457749, BY416821, BY707310, CJ279553, DN175696
    Related
    ENSMUSP00000115757.2, ENSMUST00000135924.2
    Conserved Domains (1) summary
    cd00195
    Location:12119
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  2. NM_019586.4NP_062532.2  ubiquitin-conjugating enzyme E2 J1 isoform 1

    See identical proteins and their annotated locations for NP_062532.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK149985, AL670464, AL772288, AW457749, BY416821, BY707310, CJ279553
    Consensus CDS
    CCDS18019.1
    UniProtKB/Swiss-Prot
    Q9DC92, Q9JJZ4
    Related
    ENSMUSP00000118333.2, ENSMUST00000124992.8
    Conserved Domains (1) summary
    cd00195
    Location:12119
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    33031380..33052367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)