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YTHDF2 YTH N6-methyladenosine RNA binding protein 2 [ Homo sapiens (human) ]

Gene ID: 51441, updated on 13-Mar-2020

Summary

Official Symbol
YTHDF2provided by HGNC
Official Full Name
YTH N6-methyladenosine RNA binding protein 2provided by HGNC
Primary source
HGNC:HGNC:31675
See related
Ensembl:ENSG00000198492 MIM:610640
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAHL; HGRG8; NY-REN-2
Summary
This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012]
Expression
Ubiquitous expression in bone marrow (RPKM 23.8), testis (RPKM 20.2) and 25 other tissues See more
Orthologs

Genomic context

See YTHDF2 in Genome Data Viewer
Location:
1p35.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (28736621..28769775)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (29063133..29096287)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor 12 Neighboring gene long intergenic non-protein coding RNA 1715 Neighboring gene RNA, U11 small nuclear Neighboring gene glucocorticoid modulatory element binding protein 1 Neighboring gene Sharpr-MPRA regulatory region 15715 Neighboring gene opioid receptor delta 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
N6-methyladenosine-containing RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
embryonic morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
endothelial to hematopoietic transition ISS
Inferred from Sequence or Structural Similarity
more info
 
hematopoietic stem cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
humoral immune response TAS
Traceable Author Statement
more info
PubMed 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
mRNA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
mRNA destabilization IDA
Inferred from Direct Assay
more info
PubMed 
mRNA destabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of type I interferon-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
oocyte maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cap-independent translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of hematopoietic stem cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of mRNA stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of meiotic cell cycle process involved in oocyte maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of neurogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
P-body IDA
Inferred from Direct Assay
more info
PubMed 
centriolar satellite IDA
Inferred from Direct Assay
more info
 
cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
YTH domain-containing family protein 2
Names
9430020E02Rik
CLL-associated antigen KW-14
YTH N(6)-methyladenosine RNA binding protein 2
YTH domain family, member 2
high-glucose-regulated protein 8
renal carcinoma antigen NY-REN-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016746.1 RefSeqGene

    Range
    4998..38152
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001172828.2NP_001166299.1  YTH domain-containing family protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001166299.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' region, which results in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, as compared to isoform 1.
    Source sequence(s)
    AL356786, AL645729
    Consensus CDS
    CCDS53287.1
    UniProtKB/Swiss-Prot
    Q9Y5A9
    Related
    ENSP00000439394.1, ENST00000541996.5
    Conserved Domains (1) summary
    pfam04146
    Location:361494
    YTH; YT521-B-like domain
  2. NM_001173128.1NP_001166599.1  YTH domain-containing family protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001166599.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a split 5' UTR exon, as compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AA603037, AK292581, BP320783, DC425394
    Consensus CDS
    CCDS41296.1
    UniProtKB/Swiss-Prot
    Q9Y5A9
    Related
    ENSP00000444660.1, ENST00000542507.5
    Conserved Domains (1) summary
    pfam04146
    Location:411544
    YTH; YT521-B-like domain
  3. NM_016258.3NP_057342.2  YTH domain-containing family protein 2 isoform 1

    See identical proteins and their annotated locations for NP_057342.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL356786, AL645729
    Consensus CDS
    CCDS41296.1
    UniProtKB/Swiss-Prot
    Q9Y5A9
    Related
    ENSP00000362918.3, ENST00000373812.8
    Conserved Domains (1) summary
    pfam04146
    Location:411544
    YTH; YT521-B-like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    28736621..28769775
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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