U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ythdf2 YTH N6-methyladenosine RNA binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 213541, updated on 18-Apr-2024

Summary

Official Symbol
Ythdf2provided by MGI
Official Full Name
YTH N6-methyladenosine RNA binding protein 2provided by MGI
Primary source
MGI:MGI:2444233
See related
Ensembl:ENSMUSG00000040025 AllianceGenome:MGI:2444233
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HGRG8; NY-REN-2; 9430020E02Rik
Summary
Enables N6-methyladenosine-containing RNA binding activity. Involved in several processes, including gamete generation; hematopoietic stem cell proliferation; and negative regulation of gene expression. Located in cytoplasm and nucleus. Is expressed in brain. Orthologous to human YTHDF2 (YTH N6-methyladenosine RNA binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 11.2), whole brain E14.5 (RPKM 10.9) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
4 D2.3; 4 64.92 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (131912227..131939567, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (132184916..132212256, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene opioid receptor, delta 1 Neighboring gene STARR-seq mESC enhancer starr_11554 Neighboring gene nuclear encoded tRNA alanine 3 (anticodon CGC) Neighboring gene predicted gene 13215 Neighboring gene STARR-seq mESC enhancer starr_11556 Neighboring gene STARR-seq mESC enhancer starr_11557 Neighboring gene ribosomal protein S15A, pseudogene 4 Neighboring gene glucocorticoid modulatory element binding protein 1 Neighboring gene cytochrome c-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables C5-methylcytidine-containing RNA reader activity ISO
Inferred from Sequence Orthology
more info
 
enables N6-methyladenosine-containing RNA reader activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables N6-methyladenosine-containing RNA reader activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables N6-methyladenosine-containing RNA reader activity ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in gamete generation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hematopoietic stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA destabilization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mRNA destabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA destabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in oocyte maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within oogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in organelle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cap-independent translational initiation ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in positive regulation of translational initiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of hematopoietic stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mRNA stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mRNA stability ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of meiotic cell cycle process involved in oocyte maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of rRNA processing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatogonial cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in stress granule assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in P-body ISO
Inferred from Sequence Orthology
more info
 
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
YTH domain-containing family protein 2
Names
YTH domain family 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145393.4NP_663368.3  YTH domain-containing family protein 2

    See identical proteins and their annotated locations for NP_663368.3

    Status: VALIDATED

    Source sequence(s)
    AK034655, AK150669, BX537301
    Consensus CDS
    CCDS18719.1
    UniProtKB/Swiss-Prot
    Q3TWU3, Q8BM70, Q8K325, Q91YT7
    UniProtKB/TrEMBL
    Q3UNH5
    Related
    ENSMUSP00000120414.2, ENSMUST00000152796.8
    Conserved Domains (1) summary
    pfam04146
    Location:411544
    YTH; YT521-B-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    131912227..131939567 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)