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PDE4B phosphodiesterase 4B [ Homo sapiens (human) ]

Gene ID: 5142, updated on 7-Dec-2018

Summary

Official Symbol
PDE4Bprovided by HGNC
Official Full Name
phosphodiesterase 4Bprovided by HGNC
Primary source
HGNC:HGNC:8781
See related
Ensembl:ENSG00000184588 MIM:600127
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DPDE4; PDEIVB
Summary
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Expression
Broad expression in bone marrow (RPKM 18.7), brain (RPKM 17.6) and 22 other tissues See more
Orthologs

Genomic context

See PDE4B in Genome Data Viewer
Location:
1p31.3
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (65792510..66374579)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (66258193..66840262)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene leptin receptor Neighboring gene polypeptide N-acetylgalactosaminyltransferase 11 pseudogene Neighboring gene RNA, 7SL, cytoplasmic 854, pseudogene Neighboring gene uncharacterized LOC101927139 Neighboring gene RNA, U4 small nuclear 88, pseudogene Neighboring gene uncharacterized LOC105378776 Neighboring gene SH3 domain GRB2 like endophilin interacting protein 1 Neighboring gene microRNA 3117

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome wide association study of SNP-, gene-, and pathway-based approaches to identify genes influencing susceptibility to Staphylococcus aureus infections.
NHGRI GWA Catalog
Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study.
NHGRI GWA Catalog
Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia.
NHGRI GWA Catalog
Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.
NHGRI GWA Catalog
The genetic architecture of economic and political preferences.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Cyclic AMP phosphodiesterase inhibitors AV411 and AV1013 inhibit HIV-1 replication and block HIV-1 Tat-induced neurotoxicity in human microglia, suggesting that cyclic AMP phosphodiesterase is involved in the Tat-mediated neurotoxicity PubMed
tat HIV-1 Tat decreases the intracellular levels of cAMP and CREB ser-133 phosphorylation through a signal transduction pathway involving sequential activation of phosphatidylinositol 3-kinase, AKT, and cyclic nucleoside phosphodiesterases PubMed
tat HIV-1 Tat protein, in combination with anti-CD3/CD28 mAbs, promotes IL-2 production and proliferation of primary CD4+ T lymphocytes by recruiting cyclic nucleoside phosphodiesterase 4, resulting in increased susceptibility to HIV-1 infection PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • DARPP-32 events, organism-specific biosystem (from REACTOME)
    DARPP-32 events, organism-specific biosystemDopamine- and cAMP-regulated phosphoprotein, Mr 32 kDa (DARPP-32), was identified as a major target for dopamine and protein kinase A (PKA) in striatum. Recent advances now indicate that regulation D...
  • G Protein Signaling Pathways, organism-specific biosystem (from WikiPathways)
    G Protein Signaling Pathways, organism-specific biosystemG proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades. G proteins are so called because they function as "molecular switches". They...
  • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (s) signalling events, organism-specific biosystemThe general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to col...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • Morphine addiction, organism-specific biosystem (from KEGG)
    Morphine addiction, organism-specific biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
  • Morphine addiction, conserved biosystem (from KEGG)
    Morphine addiction, conserved biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
  • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
    Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
  • Opioid Signalling, organism-specific biosystem (from REACTOME)
    Opioid Signalling, organism-specific biosystemOpioids are chemical substances similar to opiates, the active substances found in opium (morphine, codeine etc.). Opioid action is mediated by the receptors for endogenous opioids; peptides such as...
  • Purine metabolism, organism-specific biosystem (from KEGG)
    Purine metabolism, organism-specific biosystem
    Purine metabolism
  • Purine metabolism, conserved biosystem (from KEGG)
    Purine metabolism, conserved biosystem
    Purine metabolism
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • cAMP signaling pathway, organism-specific biosystem (from KEGG)
    cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cAMP signaling pathway, conserved biosystem (from KEGG)
    cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126529, DKFZp686F2182

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
PubMed 
3',5'-cyclic-AMP phosphodiesterase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
3',5'-cyclic-AMP phosphodiesterase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
3',5'-cyclic-AMP phosphodiesterase activity TAS
Traceable Author Statement
more info
 
cAMP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cAMP binding IGI
Inferred from Genetic Interaction
more info
PubMed 
gamma-tubulin binding IEA
Inferred from Electronic Annotation
more info
 
ion channel binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion channel binding ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
cAMP catabolic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to drug ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to epinephrine stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
 
leukocyte migration ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of relaxation of cardiac muscle ISS
Inferred from Sequence or Structural Similarity
more info
 
neutrophil chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
neutrophil homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interferon-gamma production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cardiac muscle cell contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of high voltage-gated calcium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Z disc ISS
Inferred from Sequence or Structural Similarity
more info
 
centrosome IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendritic spine IEA
Inferred from Electronic Annotation
more info
 
excitatory synapse IEA
Inferred from Electronic Annotation
more info
 
gamma-tubulin complex IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle IEA
Inferred from Electronic Annotation
more info
 
voltage-gated calcium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Names
dunce-like phosphodiesterase E4
phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)
NP_001032416.1
NP_001032417.1
NP_001032418.1
NP_001284369.1
NP_001284370.1
NP_001284371.1
NP_002591.2
XP_005270981.1
XP_005270982.1
XP_006710743.1
XP_016856934.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029038.1 RefSeqGene

    Range
    5001..587070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001037339.2NP_001032416.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 2

    See identical proteins and their annotated locations for NP_001032416.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant a. It represents use of an alternate promoter and initiates translation at an alternate start codon. The encoded isoform (2, also known as PDE4B2 or PDE32) has a shorter and distinct N-terminus when compared to isoform 1.
    Source sequence(s)
    AW519027, BC036108, DC399916, L12686, M97515
    Consensus CDS
    CCDS30743.1
    UniProtKB/Swiss-Prot
    Q07343
    Related
    ENSP00000360084.5, ENST00000371045.9
    Conserved Domains (1) summary
    pfam00233
    Location:233470
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  2. NM_001037340.2NP_001032417.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 3

    See identical proteins and their annotated locations for NP_001032417.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (c) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant a. It represents use of an alternate promoter and initiates translation at an alternate start codon. The encoded isoform (3, also known as PDE4B3) has a shorter and distinct N-terminus when compared to isoform 1.
    Source sequence(s)
    AB209081, AW519027, BC036108, BC101480, DA332822, L12686
    Consensus CDS
    CCDS30742.1
    UniProtKB/Swiss-Prot
    Q07343
    UniProtKB/TrEMBL
    Q59GM8
    Related
    ENSP00000392947.2, ENST00000423207.6
    Conserved Domains (1) summary
    pfam00233
    Location:390631
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  3. NM_001037341.1NP_001032418.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 1

    See identical proteins and their annotated locations for NP_001032418.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (d) differs in the 5' UTR, compared to variant a. Both variants a and d encode the same isoform (1, also known as PDE4B1 or Tm72).
    Source sequence(s)
    AW519027, BC046161, BC071607, BC101480, DA103627
    Consensus CDS
    CCDS632.1
    UniProtKB/Swiss-Prot
    Q07343
    UniProtKB/TrEMBL
    X5DNX5
    Related
    ENSP00000332116.4, ENST00000329654.8
    Conserved Domains (1) summary
    pfam00233
    Location:405646
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  4. NM_001297440.1NP_001284369.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (e) differs in the 5' UTR and lacks an alternate exon in the 5' coding region and initiates translation at an alternate downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter and distinct N-terminus when compared to isoform 1.
    Source sequence(s)
    AW519027, BC036108, CR749667, DA103627, L12686, M97515
    UniProtKB/Swiss-Prot
    Q07343
    UniProtKB/TrEMBL
    Q68CX5
    Conserved Domains (1) summary
    pfam00233
    Location:313554
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  5. NM_001297441.1NP_001284370.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (f) differs in the 5' UTR and contains multiple differences in the 5' coding region, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AL357273, AL590783, AW519027, BC036108, BF513098, KJ534917, L12686, M97515
    UniProtKB/Swiss-Prot
    Q07343
    UniProtKB/TrEMBL
    X5DR82
    Conserved Domains (1) summary
    pfam00233
    Location:330571
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  6. NM_001297442.1NP_001284371.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 6

    See identical proteins and their annotated locations for NP_001284371.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (g) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant a. It represents use of an alternate promoter and initiates translation at an alternate start codon. The encoded isoform (6, also known as PDE4B5) has a shorter and distinct N-terminus when compared to isoform 1.
    Source sequence(s)
    AK290206, AW519027, BC036108, DA311741, L12686, M97515
    Consensus CDS
    CCDS72802.1
    UniProtKB/Swiss-Prot
    Q07343
    Related
    ENSP00000432592.1, ENST00000480109.2
    Conserved Domains (1) summary
    pfam00233
    Location:172409
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  7. NM_002600.4NP_002591.2  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 1

    See identical proteins and their annotated locations for NP_002591.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) encodes the longest isoform (1, also referred to as PDE4B1 or Tm72). Both variants a and d encode the same isoform.
    Source sequence(s)
    AA206316, AA453531, AL513493, BC046161, CN268011, DA126733, L20966
    Consensus CDS
    CCDS632.1
    UniProtKB/Swiss-Prot
    Q07343
    UniProtKB/TrEMBL
    X5DNX5
    Related
    ENSP00000342637.4, ENST00000341517.8
    Conserved Domains (1) summary
    pfam00233
    Location:405646
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    65792510..66374579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001445.1XP_016856934.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1

  2. XM_005270925.2XP_005270982.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X3

    See identical proteins and their annotated locations for XP_005270982.1

    Conserved Domains (1) summary
    pfam00233
    Location:186423
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  3. XM_006710680.3XP_006710743.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X2

    Conserved Domains (1) summary
    pfam00233
    Location:200437
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  4. XM_005270924.3XP_005270981.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X3

    See identical proteins and their annotated locations for XP_005270981.1

    Conserved Domains (1) summary
    pfam00233
    Location:186423
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
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