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WDR83OS WD repeat domain 83 opposite strand [ Homo sapiens (human) ]

Gene ID: 51398, updated on 27-Nov-2024

Summary

Official Symbol
WDR83OSprovided by HGNC
Official Full Name
WD repeat domain 83 opposite strandprovided by HGNC
Primary source
HGNC:HGNC:30203
See related
Ensembl:ENSG00000105583 MIM:618474; AllianceGenome:HGNC:30203
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAT10; PAT-10; PTD008; ASTERIX; NEDFHCA; C19orf56
Summary
Enables protein folding chaperone. Involved in multi-pass transmembrane protein insertion into ER membrane. Located in endoplasmic reticulum membrane. Part of multi-pass translocon complex and protein folding chaperone complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary (RPKM 32.4), thyroid (RPKM 28.3) and 25 other tissues See more
Orthologs
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Genomic context

See WDR83OS in Genome Data Viewer
Location:
19p13.13
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (12668073..12669415, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (12792571..12793913, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12778887..12780229, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:12754106-12755305 Neighboring gene ribosomal protein L10 pseudogene 16 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14063 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10155 Neighboring gene mannosidase alpha class 2B member 1 Neighboring gene MPRA-validated peak3365 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:12775226-12776174 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:12776175-12777122 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10156 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14069 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14070 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:12781177-12781850 Neighboring gene WD repeat domain 83 Neighboring gene CRISPRi-FlowFISH-validated DHPS regulatory element Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14071 Neighboring gene deoxyhypusine synthase Neighboring gene CRISPRi-FlowFISH-validated WDR83OS regulatory elements Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:12793915-12794437 Neighboring gene G protein subunit gamma 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein folding chaperone IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in multi-pass transmembrane protein insertion into ER membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
 
involved_in protein insertion into ER membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein insertion into ER membrane IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of multi-pass translocon complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of multi-pass translocon complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of protein folding chaperone complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
PAT complex subunit Asterix
Names
UPF0139 membrane protein C19orf56
WDR83 opposite strand
protein Asterix
protein associated with the ER translocon of 10kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016145.4NP_057229.1  PAT complex subunit Asterix

    See identical proteins and their annotated locations for NP_057229.1

    Status: VALIDATED

    Source sequence(s)
    AF078861
    Consensus CDS
    CCDS12274.1
    UniProtKB/Swiss-Prot
    B2R4T8, Q9BVI3, Q9Y284
    Related
    ENSP00000468969.1, ENST00000596731.7
    Conserved Domains (1) summary
    pfam03669
    Location:5103
    UPF0139; Uncharacterized protein family (UPF0139)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    12668073..12669415 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    12792571..12793913 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)