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CRLF3 cytokine receptor like factor 3 [ Homo sapiens (human) ]

Gene ID: 51379, updated on 7-Jan-2024

Summary

Official Symbol
CRLF3provided by HGNC
Official Full Name
cytokine receptor like factor 3provided by HGNC
Primary source
HGNC:HGNC:17177
See related
Ensembl:ENSG00000176390 MIM:614853; AllianceGenome:HGNC:17177
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FRWS; CRLM9; p48.2; CREME9; CYTOR4; CREME-9
Summary
This gene encodes a cytokine receptor-like factor that may negatively regulate cell cycle progression at the G0/G1 phase. Studies of the related rat protein suggest that it may regulate neuronal morphology and synaptic vesicle biogenesis. This gene is one of several genes located in the neurofibromatosis type I tumor suppressor region on the q arm of chromosome 17, a region that is subject to microdeletions, duplications, chromosomal breaks and rearrangements. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2 and 5. [provided by RefSeq, Aug 2012]
Expression
Broad expression in lymph node (RPKM 15.5), appendix (RPKM 12.1) and 24 other tissues See more
Orthologs
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Genomic context

See CRLF3 in Genome Data Viewer
Location:
17q11.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (30782684..30824692, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (31727662..31770401, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (29109702..29151710, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene SMURF2P1-LRRC37BP1 readthrough transcribed pseudogene Neighboring gene leucine rich repeat containing 37B pseudogene Neighboring gene leucine rich repeat containing 37B pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 474 Neighboring gene NF1-REPa PRS1 recombination region Neighboring gene uncharacterized LOC105371723 Neighboring gene NF1-REPa PRS2 recombination region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:28993682-28994231 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:28994232-28994780 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:28994781-28995330 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:29026421-29027394 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:29027395-29028368 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12000 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:29036042-29036718 Neighboring gene RNA, 7SL, cytoplasmic 316, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12001 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:29058617-29059237 Neighboring gene SUZ12 pseudogene 1 Neighboring gene SUZ12P1 PRS4 recombination region Neighboring gene Sharpr-MPRA regulatory region 4018 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:29157944-29158579 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:29158580-29159216 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:29159217-29159851 Neighboring gene ribosomal protein S17 pseudogene 3 Neighboring gene ATPase family AAA domain containing 5 Neighboring gene RNA, U6 small nuclear 298, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC20661

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
cytokine receptor-like factor 3
Names
cytokine receptor-like molecule 9
cytokine receptor-related protein 4
type I cytokine receptor-like factor p48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032911.2 RefSeqGene

    Range
    5069..47077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_648

mRNA and Protein(s)

  1. NM_015986.4NP_057070.3  cytokine receptor-like factor 3

    See identical proteins and their annotated locations for NP_057070.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the supported protein.
    Source sequence(s)
    AA993312, BC023567, BU902521
    Consensus CDS
    CCDS32607.1
    UniProtKB/Swiss-Prot
    A6NJF3, B2R8C3, Q2MLY7, Q8IUI8, Q9UNI3, Q9Y6M8
    Related
    ENSP00000318804.6, ENST00000324238.7
    Conserved Domains (1) summary
    cd00063
    Location:181265
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RNA

  1. NR_073118.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA993312, AK296238, BC023567, BU902521

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    30782684..30824692 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    31727662..31770401 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)