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CRLF3 cytokine receptor like factor 3 [ Homo sapiens (human) ]

Gene ID: 51379, updated on 24-Nov-2017
Official Symbol
CRLF3provided by HGNC
Official Full Name
cytokine receptor like factor 3provided by HGNC
Primary source
HGNC:HGNC:17177
See related
Ensembl:ENSG00000176390 MIM:614853; Vega:OTTHUMG00000179005
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FRWS; CRLM9; p48.2; CREME9; CYTOR4; CREME-9
Summary
This gene encodes a cytokine receptor-like factor that may negatively regulate cell cycle progression at the G0/G1 phase. Studies of the related rat protein suggest that it may regulate neuronal morphology and synaptic vesicle biogenesis. This gene is one of several genes located in the neurofibromatosis type I tumor suppressor region on the q arm of chromosome 17, a region that is subject to microdeletions, duplications, chromosomal breaks and rearrangements. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2 and 5. [provided by RefSeq, Aug 2012]
Expression
Broad expression in lymph node (RPKM 15.5), appendix (RPKM 12.1) and 24 other tissues See more
Orthologs
Location:
17q11.2
Exon count:
9
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (30782684..30824760, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (29109702..29151778, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371723 Neighboring gene RNA, 7SL, cytoplasmic 316, pseudogene Neighboring gene SUZ12 polycomb repressive complex 2 subunit pseudogene 1 Neighboring gene ribosomal protein S17 pseudogene 3 Neighboring gene ATPase family, AAA domain containing 5 Neighboring gene transcription elongation factor, mitochondrial

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC20661

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
Preferred Names
cytokine receptor-like factor 3
Names
cytokine receptor-like molecule 9
cytokine receptor-related protein 4
type I cytokine receptor-like factor p48

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032911.2 RefSeqGene

    Range
    5001..47077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_015986.3NP_057070.3  cytokine receptor-like factor 3

    See identical proteins and their annotated locations for NP_057070.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the supported protein.
    Source sequence(s)
    AA993312, BC023567, BU902521
    Consensus CDS
    CCDS32607.1
    UniProtKB/Swiss-Prot
    Q8IUI8
    Related
    ENSP00000318804.6, OTTHUMP00000260489, ENST00000324238.6, OTTHUMT00000444354
    Conserved Domains (1) summary
    cd00063
    Location:181265
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RNA

  1. NR_073118.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA993312, AK296238, BC023567, BU902521

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

    Range
    30782684..30824760 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524879.1XP_011523181.1  cytokine receptor-like factor 3 isoform X1

    See identical proteins and their annotated locations for XP_011523181.1

    UniProtKB/TrEMBL
    B4DJU5
    Conserved Domains (1) summary
    cd00063
    Location:65149
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RNA

  1. XR_001752525.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    29172304..29214372 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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