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UBR5 ubiquitin protein ligase E3 component n-recognin 5 [ Homo sapiens (human) ]

Gene ID: 51366, updated on 1-Jun-2020

Summary

Official Symbol
UBR5provided by HGNC
Official Full Name
ubiquitin protein ligase E3 component n-recognin 5provided by HGNC
Primary source
HGNC:HGNC:16806
See related
Ensembl:ENSG00000104517 MIM:608413
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DD5; EDD; HYD; EDD1
Summary
This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 18.7), lymph node (RPKM 11.2) and 25 other tissues See more
Orthologs

Genomic context

See UBR5 in Genome Data Viewer
Location:
8q22.3
Exon count:
60
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (102252273..102412700, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (103264501..103424947, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ribonucleotide reductase regulatory TP53 inducible subunit M2B Neighboring gene UBR5 antisense RNA 1 Neighboring gene SUMO2 pseudogene 19 Neighboring gene uncharacterized LOC105375683 Neighboring gene RNA, U6atac small nuclear 8, pseudogene Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ubiquitin protein ligase E3 component n-recognin 5 (UBR5) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr The interaction of HIV-1 Vpr with the EDVP E3 ligase complex (EDD, DDB1, and VPRBP) promotes Vpr-mediated downregulation of TERT protein PubMed
vpr The interaction of Vpr with DDB1 facilitates the formation of complexes containing Cul4A-Roc1 E3 ubiquitin ligase. The association of Vpr with DDB1-containing E3 ligase mediates the degradation of UNG2 and SMUG1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11310, KIAA0896, MGC57263

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-ubiquitin ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of histone H2A K63-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of histone H2A K63-linked ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
progesterone receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
regulation of double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase UBR5
Names
E3 identified by differential display
E3 ubiquitin-protein ligase, HECT domain-containing 1
HECT-type E3 ubiquitin transferase UBR5
hyperplastic discs protein homolog
progestin-induced protein
NP_001269802.1
NP_056986.2
XP_005251019.1
XP_011515406.2
XP_011515407.2
XP_011515408.2
XP_016869022.1
XP_016869023.1
XP_024302946.1
XP_024302947.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047152.1 RefSeqGene

    Range
    4990..165417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001282873.1NP_001269802.1  E3 ubiquitin-protein ligase UBR5 isoform 2

    See identical proteins and their annotated locations for NP_001269802.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB020703, AL833555, AP002907, BC037843
    Consensus CDS
    CCDS64946.1
    UniProtKB/Swiss-Prot
    O95071
    Related
    ENSP00000220959.4, ENST00000220959.8
    Conserved Domains (5) summary
    smart00396
    Location:11771244
    ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
    smart00517
    Location:23892452
    PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
    smart00119
    Location:25002795
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00632
    Location:25002798
    HECT; HECT-domain (ubiquitin-transferase)
    pfam11547
    Location:179226
    E3_UbLigase_EDD; E3 ubiquitin ligase EDD
  2. NM_015902.6NP_056986.2  E3 ubiquitin-protein ligase UBR5 isoform 1

    See identical proteins and their annotated locations for NP_056986.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB020703, AP002907, AP002981, BX489192
    Consensus CDS
    CCDS34933.1
    UniProtKB/Swiss-Prot
    O95071
    Related
    ENSP00000429084.1, ENST00000520539.6
    Conserved Domains (5) summary
    smart00396
    Location:11771244
    ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
    smart00517
    Location:23892452
    PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
    smart00119
    Location:25012796
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00632
    Location:25012799
    HECT; HECT-domain (ubiquitin-transferase)
    pfam11547
    Location:179226
    E3_UbLigase_EDD; E3 ubiquitin ligase EDD

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    102252273..102412700 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013533.2XP_016869022.1  E3 ubiquitin-protein ligase UBR5 isoform X3

  2. XM_011517105.3XP_011515407.2  E3 ubiquitin-protein ligase UBR5 isoform X2

  3. XM_017013534.2XP_016869023.1  E3 ubiquitin-protein ligase UBR5 isoform X4

    Related
    ENSP00000427819.1, ENST00000521922.5
  4. XM_011517106.3XP_011515408.2  E3 ubiquitin-protein ligase UBR5 isoform X5

  5. XM_011517104.3XP_011515406.2  E3 ubiquitin-protein ligase UBR5 isoform X1

  6. XM_024447179.1XP_024302947.1  E3 ubiquitin-protein ligase UBR5 isoform X7

    Conserved Domains (3) summary
    smart00396
    Location:923990
    ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
    smart00517
    Location:21372200
    PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
    smart00119
    Location:22492544
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
  7. XM_024447178.1XP_024302946.1  E3 ubiquitin-protein ligase UBR5 isoform X6

    Conserved Domains (3) summary
    smart00396
    Location:929996
    ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
    smart00517
    Location:21432206
    PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
    smart00119
    Location:22552550
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
  8. XM_005250962.5XP_005251019.1  E3 ubiquitin-protein ligase UBR5 isoform X8

    Conserved Domains (4) summary
    smart00396
    Location:187254
    ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
    smart00517
    Location:14011464
    PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
    smart00119
    Location:15131808
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00632
    Location:15131811
    HECT; HECT-domain (ubiquitin-transferase)

RNA

  1. XR_001745539.2 RNA Sequence

  2. XR_001745540.2 RNA Sequence

  3. XR_001745541.2 RNA Sequence

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