Format

Send to:

Choose Destination

HOOK1 hook microtubule tethering protein 1 [ Homo sapiens (human) ]

Gene ID: 51361, updated on 10-Oct-2019

Summary

Official Symbol
HOOK1provided by HGNC
Official Full Name
hook microtubule tethering protein 1provided by HGNC
Primary source
HGNC:HGNC:19884
See related
Ensembl:ENSG00000134709 MIM:607820
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HK1
Summary
This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 15.7), colon (RPKM 10.0) and 21 other tissues See more
Orthologs

Genomic context

See HOOK1 in Genome Data Viewer
Location:
1p32.1
Exon count:
25
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (59814922..59876370)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (60280458..60342050)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene FGGY carbohydrate kinase domain containing Neighboring gene uncharacterized LOC101926944 Neighboring gene microRNA 4711 Neighboring gene uncharacterized LOC105378758 Neighboring gene cytochrome P450 family 2 subfamily J member 2 Neighboring gene RNA, 7SL, cytoplasmic 475, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC10642

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Golgi organization IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeleton-dependent intracellular transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
early endosome to late endosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
endosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
endosome to lysosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
lysosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
manchette assembly IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
FHF complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with HOPS complex IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein Hook homolog 1
Names
h-hook1
hHK1
hook homolog 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015888.6NP_056972.1  protein Hook homolog 1

    See identical proteins and their annotated locations for NP_056972.1

    Status: REVIEWED

    Source sequence(s)
    AC113175, AL035416
    Consensus CDS
    CCDS612.1
    UniProtKB/Swiss-Prot
    Q9UJC3
    Related
    ENSP00000360252.3, ENST00000371208.4
    Conserved Domains (1) summary
    pfam05622
    Location:15720
    HOOK; HOOK protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    59814922..59876370
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541563.1XP_011539865.1  protein Hook homolog 1 isoform X4

    Conserved Domains (3) summary
    pfam05622
    Location:15546
    HOOK; HOOK protein
    pfam11221
    Location:175210
    Med21; Subunit 21 of Mediator complex
    cl17182
    Location:486533
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
  2. XM_006710676.1XP_006710739.1  protein Hook homolog 1 isoform X3

    Conserved Domains (3) summary
    pfam05622
    Location:15534
    HOOK; HOOK protein
    pfam11221
    Location:175210
    Med21; Subunit 21 of Mediator complex
    cl17182
    Location:486533
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
  3. XM_017001424.1XP_016856913.1  protein Hook homolog 1 isoform X5

  4. XM_011541562.2XP_011539864.1  protein Hook homolog 1 isoform X2

    Conserved Domains (3) summary
    pfam05622
    Location:9678
    HOOK; HOOK protein
    pfam11221
    Location:133168
    Med21; Subunit 21 of Mediator complex
    cl19219
    Location:460542
    DUF342; Protein of unknown function (DUF342)
  5. XM_024447520.1XP_024303288.1  protein Hook homolog 1 isoform X1

    Conserved Domains (1) summary
    pfam05622
    Location:1678
    HOOK; HOOK protein

RNA

  1. XR_946665.1 RNA Sequence

  2. XR_246271.1 RNA Sequence

Support Center