U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hook1 hook microtubule tethering protein 1 [ Mus musculus (house mouse) ]

Gene ID: 77963, updated on 12-May-2024

Summary

Official Symbol
Hook1provided by MGI
Official Full Name
hook microtubule tethering protein 1provided by MGI
Primary source
MGI:MGI:1925213
See related
Ensembl:ENSMUSG00000028572 AllianceGenome:MGI:1925213
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
azh; A930033L17Rik
Summary
Enables actin binding activity and microtubule binding activity. Acts upstream of or within Golgi organization; cytoplasmic microtubule organization; and manchette assembly. Located in microtubule cytoskeleton. Is expressed in embryo; forelimb bud; spermatid; and testis. Orthologous to human HOOK1 (hook microtubule tethering protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 19.9), CNS E18 (RPKM 15.8) and 22 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Hook1 in Genome Data Viewer
Location:
4 C5; 4 44.17 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (95855418..95913649)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (95967181..96025412)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1032 Neighboring gene predicted gene, 40206 Neighboring gene FGGY carbohydrate kinase domain containing Neighboring gene STARR-seq mESC enhancer starr_10810 Neighboring gene STARR-seq mESC enhancer starr_10811 Neighboring gene STARR-seq mESC enhancer starr_10812 Neighboring gene STARR-seq mESC enhancer starr_10813 Neighboring gene STARR-seq mESC enhancer starr_10814 Neighboring gene RIKEN cDNA 9530080O11 gene Neighboring gene STARR-positive B cell enhancer ABC_E1647 Neighboring gene STARR-seq mESC enhancer starr_10816 Neighboring gene STARR-seq mESC enhancer starr_10817 Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 13 Neighboring gene STARR-seq mESC enhancer starr_10818 Neighboring gene heat shock protein 1 (chaperonin 10), pseudogene 6 Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 12

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Radiation induced (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Golgi organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cytoplasmic microtubule organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytoskeleton-dependent intracellular transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
 
involved_in endosome organization ISO
Inferred from Sequence Orthology
more info
 
involved_in endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
 
involved_in lysosome organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within manchette assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within spermatid development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of FHF complex ISO
Inferred from Sequence Orthology
more info
 
part_of HOPS complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein Hook homolog 1
Names
abnormal spermatozoon head shape
hook homolog 1
mHK1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030014.2NP_084290.1  protein Hook homolog 1

    See identical proteins and their annotated locations for NP_084290.1

    Status: PROVISIONAL

    Source sequence(s)
    BC061688
    Consensus CDS
    CCDS18367.1
    UniProtKB/Swiss-Prot
    Q8BIL5, Q8BIZ2, Q8K0P1, Q8K454, Q9CTN6
    Related
    ENSMUSP00000030306.8, ENSMUST00000030306.14
    Conserved Domains (3) summary
    pfam05622
    Location:14720
    HOOK; HOOK protein
    pfam11221
    Location:175210
    Med21; Subunit 21 of Mediator complex
    cl19219
    Location:502584
    DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    95855418..95913649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503488.4XP_006503551.1  protein Hook homolog 1 isoform X3

    Conserved Domains (1) summary
    pfam05622
    Location:14546
    HOOK; HOOK protein
  2. XM_006503487.4XP_006503550.1  protein Hook homolog 1 isoform X2

    Conserved Domains (1) summary
    pfam05622
    Location:14534
    HOOK; HOOK protein
  3. XM_030253920.2XP_030109780.1  protein Hook homolog 1 isoform X1

    Conserved Domains (1) summary
    pfam05622
    Location:1678
    HOOK; HOOK protein

RNA

  1. XR_001784219.2 RNA Sequence

  2. XR_001784220.2 RNA Sequence

  3. XR_376377.4 RNA Sequence

  4. XR_376374.4 RNA Sequence