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MEX3C mex-3 RNA binding family member C [ Homo sapiens (human) ]

Gene ID: 51320, updated on 23-Nov-2021

Summary

Official Symbol
MEX3Cprovided by HGNC
Official Full Name
mex-3 RNA binding family member Cprovided by HGNC
Primary source
HGNC:HGNC:28040
See related
Ensembl:ENSG00000176624 MIM:611005
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RKHD2; BM-013; MEX-3C; RNF194
Summary
This gene encodes a member of a family of proteins with two K homology (KH) RNA-binding domains and a C-terminal RING-finger domain. The protein interacts with mRNA via the KH domains, and the protein shuttles between the nucleus and cytoplasm. Polymorphisms in this gene may contribute to hypertension. [provided by RefSeq, Oct 2009]
Expression
Broad expression in testis (RPKM 32.6), lymph node (RPKM 11.1) and 24 other tissues See more
Orthologs
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Genomic context

See MEX3C in Genome Data Viewer
Location:
18q21.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (51174550..51197681, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (48700920..48724051, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372117 Neighboring gene SMAD family member 4 Neighboring gene serine and arginine rich splicing factor 10 pseudogene 1 Neighboring gene uncharacterized LOC105372118 Neighboring gene RNA, U1 small nuclear 46, pseudogene Neighboring gene long intergenic non-protein coding RNA 1630 Neighboring gene SS18 like 2 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed.
GeneReviews: Not available
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38871

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in chondrocyte hypertrophy IEA
Inferred from Electronic Annotation
more info
 
involved_in energy homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
RNA-binding E3 ubiquitin-protein ligase MEX3C
Names
MEX3C variant 1
MEX3C variant 2
RING finger and KH domain-containing protein 2
RING finger protein 194
RING-type E3 ubiquitin transferase MEX3C
RNA-binding protein MEX3C
ring finger and KH domain containing 2
NP_057710.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015801.1 RefSeqGene

    Range
    5001..28132
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_016626.5NP_057710.3  RNA-binding E3 ubiquitin-protein ligase MEX3C

    See identical proteins and their annotated locations for NP_057710.3

    Status: REVIEWED

    Source sequence(s)
    AC090330, AY950679, BC063244
    Consensus CDS
    CCDS11951.2
    UniProtKB/Swiss-Prot
    Q5U5Q3
    Related
    ENSP00000385610.3, ENST00000406189.4
    Conserved Domains (3) summary
    smart00322
    Location:326391
    KH; K homology RNA-binding domain
    cd00105
    Location:233294
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam13920
    Location:608653
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    51174550..51197681 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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