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Mex3c mex3 RNA binding family member C [ Mus musculus (house mouse) ]

Gene ID: 240396, updated on 26-Sep-2022

Summary

Official Symbol
Mex3cprovided by MGI
Official Full Name
mex3 RNA binding family member Cprovided by MGI
Primary source
MGI:MGI:2652843
See related
Ensembl:ENSMUSG00000037253 AllianceGenome:MGI:2652843
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rkhd2; BM-013; A130001D14Rik
Summary
Predicted to enable RNA binding activity and ubiquitin protein ligase activity. Acts upstream of or within chondrocyte hypertrophy; energy homeostasis; and regulation of fat cell differentiation. Predicted to be located in cytoplasm and nucleus. Is expressed in genitourinary system. Orthologous to human MEX3C (mex-3 RNA binding family member C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 12.1), CNS E11.5 (RPKM 9.7) and 28 other tissues See more
Orthologs
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Genomic context

See Mex3c in Genome Data Viewer
Location:
18; 18 E2
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (73705710..73725649)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (73572637..73592578)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54025 Neighboring gene predicted gene, 32022 Neighboring gene SMAD family member 4 Neighboring gene RIKEN cDNA 4930578L24 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
RNA-binding E3 ubiquitin-protein ligase MEX3C
Names
RING finger and KH domain-containing protein 2
RING-type E3 ubiquitin transferase MEX3C
RNA-binding protein MEX3C
mex3 homolog C
ring finger and KH domain containing 2
NP_001034303.3
XP_011245234.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039214.4NP_001034303.3  RNA-binding E3 ubiquitin-protein ligase MEX3C

    See identical proteins and their annotated locations for NP_001034303.3

    Status: VALIDATED

    Source sequence(s)
    BB618103, BC108422, BC125427, BY595095, CJ067036, CJ071688
    Consensus CDS
    CCDS50318.1
    UniProtKB/Swiss-Prot
    Q05A36, Q2VPQ2
    Related
    ENSMUSP00000089463.5, ENSMUST00000091852.5
    Conserved Domains (3) summary
    smart00322
    Location:319384
    KH; K homology RNA-binding domain
    cd00105
    Location:226287
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam13920
    Location:601646
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    73705710..73725649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246932.4XP_011245234.1  RNA-binding E3 ubiquitin-protein ligase MEX3C isoform X1