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NRN1 neuritin 1 [ Homo sapiens (human) ]

Gene ID: 51299, updated on 11-Sep-2019

Summary

Official Symbol
NRN1provided by HGNC
Official Full Name
neuritin 1provided by HGNC
Primary source
HGNC:HGNC:17972
See related
Ensembl:ENSG00000124785 MIM:607409
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NRN; dJ380B8.2
Summary
This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Broad expression in brain (RPKM 29.3), fat (RPKM 22.7) and 14 other tissues See more
Orthologs

Genomic context

See NRN1 in Genome Data Viewer
Location:
6p25.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (5997999..6007605, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (5998232..6007838, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374898 Neighboring gene uncharacterized LOC107986516 Neighboring gene RNA, 7SL, cytoplasmic 221, pseudogene Neighboring gene pyruvate kinase M1/2 pseudogene 5 Neighboring gene coagulation factor XIII A chain Neighboring gene microRNA 7853 Neighboring gene microRNA 5683 Neighboring gene LY86 antisense RNA 1 Neighboring gene small nuclear RNA activating complex polypeptide 5 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC44811

Gene Ontology Provided by GOA

Process Evidence Code Pubs
nervous system development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278710.1NP_001265639.1  neuritin isoform 1 precursor

    See identical proteins and their annotated locations for NP_001265639.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    BC002683, BF970432, DB013243
    Consensus CDS
    CCDS4495.1
    UniProtKB/Swiss-Prot
    Q9NPD7
    Related
    ENSP00000484055.1, ENST00000616243.1
    Conserved Domains (1) summary
    pfam15056
    Location:31117
    NRN1; Neuritin protein family
  2. NM_001278711.1NP_001265640.1  neuritin isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a longer and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK093824, BC002683, BX340783
    Consensus CDS
    CCDS75393.1
    UniProtKB/Swiss-Prot
    Q9NPD7
    UniProtKB/TrEMBL
    A0A087WWT2
    Related
    ENSP00000480483.1, ENST00000622188.4
    Conserved Domains (1) summary
    pfam15056
    Location:57143
    NRN1; Neuritin protein family
  3. NM_016588.3NP_057672.1  neuritin isoform 1 precursor

    See identical proteins and their annotated locations for NP_057672.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AL136307, BC002683
    Consensus CDS
    CCDS4495.1
    UniProtKB/Swiss-Prot
    Q9NPD7
    Related
    ENSP00000244766.2, ENST00000244766.7
    Conserved Domains (1) summary
    pfam15056
    Location:31117
    NRN1; Neuritin protein family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    5997999..6007605 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715107.3XP_006715170.1  neuritin isoform X2

    Conserved Domains (1) summary
    pfam15056
    Location:22108
    NRN1; Neuritin protein family
  2. XM_006715106.3XP_006715169.1  neuritin isoform X1

    Conserved Domains (1) summary
    pfam15056
    Location:92178
    NRN1; Neuritin protein family
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