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Nrn1 neuritin 1 [ Mus musculus (house mouse) ]

Gene ID: 68404, updated on 12-May-2024

Summary

Official Symbol
Nrn1provided by MGI
Official Full Name
neuritin 1provided by MGI
Primary source
MGI:MGI:1915654
See related
Ensembl:ENSMUSG00000039114 AllianceGenome:MGI:1915654
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nrn; Cpg15; 0710008J23Rik
Summary
Enables identical protein binding activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within neuron projection extension. Located in extracellular space. Is anchored component of plasma membrane. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut; limb mesenchyme; and liver. Orthologous to human NRN1 (neuritin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E18 (RPKM 84.3), cortex adult (RPKM 52.3) and 11 other tissues See more
Orthologs
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Genomic context

See Nrn1 in Genome Data Viewer
Location:
13 A3.3; 13 14.44 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (36909596..36918451, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (36725622..36734477, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26395 Neighboring gene predicted gene, 38636 Neighboring gene predicted gene, 30177 Neighboring gene STARR-seq mESC enhancer starr_34196 Neighboring gene predicted gene, 30489 Neighboring gene coagulation factor XIII, A1 subunit Neighboring gene STARR-seq mESC enhancer starr_34198 Neighboring gene STARR-seq mESC enhancer starr_34199 Neighboring gene STARR-seq mESC enhancer starr_34200 Neighboring gene predicted gene, 30240

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

General gene information

Markers

Clone Names

  • MGC40786

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of AMPA glutamate receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
neuritin
Names
candidate plasticity gene 15 protein
candidate plasticity-related gene 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374754.1NP_001361683.1  neuritin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC156802
    Consensus CDS
    CCDS88439.1
    UniProtKB/TrEMBL
    A0A286YD56, D3Z4E2
    Related
    ENSMUSP00000153099.2, ENSMUST00000224323.2
    Conserved Domains (1) summary
    pfam15056
    Location:40126
    NRN1; Neuritin protein family
  2. NM_153529.2NP_705757.1  neuritin isoform 1 precursor

    See identical proteins and their annotated locations for NP_705757.1

    Status: VALIDATED

    Source sequence(s)
    AC156802, AK161859, BY643925, CA321643, CD774577
    Consensus CDS
    CCDS26455.1
    UniProtKB/Swiss-Prot
    Q7TSR9, Q8CFV4
    UniProtKB/TrEMBL
    A0A286YCW7
    Related
    ENSMUSP00000040900.9, ENSMUST00000037623.15
    Conserved Domains (1) summary
    pfam15056
    Location:31117
    NRN1; Neuritin protein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    36909596..36918451 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)