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CDK17 cyclin dependent kinase 17 [ Homo sapiens (human) ]

Gene ID: 5128, updated on 1-Jun-2020

Summary

Official Symbol
CDK17provided by HGNC
Official Full Name
cyclin dependent kinase 17provided by HGNC
Primary source
HGNC:HGNC:8750
See related
Ensembl:ENSG00000059758 MIM:603440
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PCTK2; PCTAIRE2
Summary
The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jul 2010]
Expression
Ubiquitous expression in brain (RPKM 21.3), testis (RPKM 15.1) and 24 other tissues See more
Orthologs

Genomic context

See CDK17 in Genome Data Viewer
Location:
12q23.1
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (96278261..96400439, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (96672039..96794366, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369925 Neighboring gene uncharacterized LOC107984546 Neighboring gene ETS transcription factor ELK3 Neighboring gene RNA, U4 small nuclear 24, pseudogene Neighboring gene RN7SK pseudogene 11 Neighboring gene Sharpr-MPRA regulatory region 2123 Neighboring gene cilia and flagella associated protein 54

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription involved in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cyclin-dependent kinase 17
Names
PCTAIRE-motif protein kinase 2
cell division protein kinase 17
protein kinase cdc2-related PCTAIRE-2
serine/threonine-protein kinase PCTAIRE-2
NP_001163935.1
NP_002586.2
XP_016874894.1
XP_016874895.1
XP_016874896.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170464.3NP_001163935.1  cyclin-dependent kinase 17 isoform 2

    See identical proteins and their annotated locations for NP_001163935.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus but is the same length as isoform 1.
    Source sequence(s)
    AF086067, AK290011, BC033005, DA530711
    Consensus CDS
    CCDS53819.1
    UniProtKB/Swiss-Prot
    Q00537
    Related
    ENSP00000444459.2, ENST00000543119.6
    Conserved Domains (1) summary
    cd07872
    Location:185493
    STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase
  2. NM_002595.5NP_002586.2  cyclin-dependent kinase 17 isoform 1

    See identical proteins and their annotated locations for NP_002586.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.
    Source sequence(s)
    AF086067, BC033005, DC307775
    Consensus CDS
    CCDS9061.1
    UniProtKB/Swiss-Prot
    Q00537
    UniProtKB/TrEMBL
    A0A024RBH0
    Related
    ENSP00000261211.3, ENST00000261211.8
    Conserved Domains (1) summary
    cd07872
    Location:185493
    STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    96278261..96400439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019407.2XP_016874896.1  cyclin-dependent kinase 17 isoform X2

  2. XM_017019406.1XP_016874895.1  cyclin-dependent kinase 17 isoform X1

    UniProtKB/Swiss-Prot
    Q00537
    UniProtKB/TrEMBL
    A0A024RBH0
    Conserved Domains (1) summary
    cd07872
    Location:185493
    STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase
  3. XM_017019405.1XP_016874894.1  cyclin-dependent kinase 17 isoform X1

    UniProtKB/Swiss-Prot
    Q00537
    UniProtKB/TrEMBL
    A0A024RBH0
    Conserved Domains (1) summary
    cd07872
    Location:185493
    STKc_PCTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase
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