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CLEC1A C-type lectin domain family 1 member A [ Homo sapiens (human) ]

Gene ID: 51267, updated on 26-Jul-2021

Summary

Official Symbol
CLEC1Aprovided by HGNC
Official Full Name
C-type lectin domain family 1 member Aprovided by HGNC
Primary source
HGNC:HGNC:24355
See related
Ensembl:ENSG00000150048 MIM:606782
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLEC1; CLEC-1
Summary
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The encoded protein may play a role in regulating dendritic cell function. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Expression
Biased expression in placenta (RPKM 18.1), lung (RPKM 3.8) and 10 other tissues See more
Orthologs
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Genomic context

See CLEC1A in Genome Data Viewer
Location:
12p13.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (10069504..10099065, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (10222153..10251584, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene C-type lectin domain family 12 member B Neighboring gene uncharacterized LOC102724020 Neighboring gene C-type lectin domain family 1 member B pseudogene Neighboring gene C-type lectin domain containing 9A Neighboring gene RN7SK pseudogene 161 Neighboring gene uncharacterized LOC105369655 Neighboring gene heterogeneous nuclear ribonucleoprotein A/B pseudogene 1 Neighboring gene C-type lectin domain containing 7A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC34328

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in defense response TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in intracellular anatomical structure TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
C-type lectin domain family 1 member A
Names
C-type lectin-like receptor-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297748.2NP_001284677.1  C-type lectin domain family 1 member A isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AC024224, AK091989, BC067746
    Consensus CDS
    CCDS73443.1
    UniProtKB/Swiss-Prot
    Q8NC01
    UniProtKB/TrEMBL
    B3KRP6, E9PFB4
    Related
    ENSP00000415048.2, ENST00000457018.6
    Conserved Domains (1) summary
    cd03593
    Location:104226
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
  2. NM_001297749.2NP_001284678.1  C-type lectin domain family 1 member A isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 5' coding region compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC024224, AK300979, AY358587, BC067746
    Consensus CDS
    CCDS76528.1
    UniProtKB/Swiss-Prot
    Q8NC01
    UniProtKB/TrEMBL
    B4DV89, E7ESV9
    Related
    ENSP00000417010.2, ENST00000420265.2
    Conserved Domains (1) summary
    cd03593
    Location:45167
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
  3. NM_001297750.2NP_001284679.1  C-type lectin domain family 1 member A isoform d

    See identical proteins and their annotated locations for NP_001284679.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate exon compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG to encode an isoform (d) that has a shorter N-terminus, compared to isoform a. Variants 4 and 5 encode the same isoform.
    Source sequence(s)
    AC024224, AY358587, BC067746, BX380212
    UniProtKB/Swiss-Prot
    Q8NC01
    Conserved Domains (1) summary
    cd03593
    Location:49171
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
  4. NM_001297751.2NP_001284680.1  C-type lectin domain family 1 member A isoform d

    See identical proteins and their annotated locations for NP_001284680.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in an internal exon compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG to encode an isoform (d) that has a shorter N-terminus, compared to isoform a. Variants 4 and 5 encode the same isoform.
    Source sequence(s)
    AC024224, AY358587, BC067746, BX339075
    UniProtKB/Swiss-Prot
    Q8NC01
    Conserved Domains (1) summary
    cd03593
    Location:49171
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
  5. NM_016511.4NP_057595.2  C-type lectin domain family 1 member A isoform a

    See identical proteins and their annotated locations for NP_057595.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC024224, AK075114, BC067746
    Consensus CDS
    CCDS8612.1
    UniProtKB/Swiss-Prot
    Q8NC01
    Related
    ENSP00000326407.4, ENST00000315330.8
    Conserved Domains (1) summary
    cd03593
    Location:137259
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    10069504..10099065 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520687.2XP_011518989.1  C-type lectin domain family 1 member A isoform X1

    Conserved Domains (1) summary
    cd03593
    Location:164286
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
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