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Aspergillosis, susceptibility to

MedGen UID:
481404
Concept ID:
C3279774
Finding
Synonym: ASPERGILLOSIS, SUSCEPTIBILITY TO
 
Genes (locations): CLEC1A (12p13.2); CLEC7A (12p13.2)
 
Monarch Initiative: MONDO:0013562
OMIM®: 614079

Definition

Aspergillus species are ubiquitous in nature and cause a wide spectrum of diseases, including saprophytic colonization of existing cavities (aspergilloma), allergic asthma, hypersensitivity pneumonitis, allergic bronchopulmonary aspergillosis, and disseminated disease associated with high mortality rates in patients with hematologic malignancies and recipients of solid organs and stem cell transplantations. Immunocompetent and nonatopic individuals are relatively resistant to infection, and disease occurs in the setting of host damage. Association of persistent inflammation with intractable infection is common in nonneutropenic patients after hematopoietic stem cell transplantation, as well as in allergic fungal diseases. The pathophysiology underlying Aspergillus infection highlights the bipolar nature of the inflammatory process in infection, in which early inflammation prevents or limits infection, but an uncontrolled response may oppose disease eradication (summary by Cunha et al., 2010). For information on familial occurrence of allergic bronchopulmonary aspergillosis, see 103920. [from OMIM]

Professional guidelines

PubMed

Douglas AP, Smibert OC, Bajel A, Halliday CL, Lavee O, McMullan B, Yong MK, van Hal SJ, Chen SC; Australasian Antifungal Guidelines Steering Committee
Intern Med J 2021 Nov;51 Suppl 7:143-176. doi: 10.1111/imj.15591. PMID: 34937136
Cadena J, Thompson GR 3rd, Patterson TF
Infect Dis Clin North Am 2021 Jun;35(2):415-434. doi: 10.1016/j.idc.2021.03.008. PMID: 34016284
Ullmann AJ, Aguado JM, Arikan-Akdagli S, Denning DW, Groll AH, Lagrou K, Lass-Flörl C, Lewis RE, Munoz P, Verweij PE, Warris A, Ader F, Akova M, Arendrup MC, Barnes RA, Beigelman-Aubry C, Blot S, Bouza E, Brüggemann RJM, Buchheidt D, Cadranel J, Castagnola E, Chakrabarti A, Cuenca-Estrella M, Dimopoulos G, Fortun J, Gangneux JP, Garbino J, Heinz WJ, Herbrecht R, Heussel CP, Kibbler CC, Klimko N, Kullberg BJ, Lange C, Lehrnbecher T, Löffler J, Lortholary O, Maertens J, Marchetti O, Meis JF, Pagano L, Ribaud P, Richardson M, Roilides E, Ruhnke M, Sanguinetti M, Sheppard DC, Sinkó J, Skiada A, Vehreschild MJGT, Viscoli C, Cornely OA
Clin Microbiol Infect 2018 May;24 Suppl 1:e1-e38. Epub 2018 Mar 12 doi: 10.1016/j.cmi.2018.01.002. PMID: 29544767

Recent clinical studies

Etiology

Salazar F, Bignell E, Brown GD, Cook PC, Warris A
Clin Microbiol Rev 2022 Jan 19;35(1):e0009421. Epub 2021 Nov 17 doi: 10.1128/CMR.00094-21. PMID: 34788127Free PMC Article
Douglas AP, Smibert OC, Bajel A, Halliday CL, Lavee O, McMullan B, Yong MK, van Hal SJ, Chen SC; Australasian Antifungal Guidelines Steering Committee
Intern Med J 2021 Nov;51 Suppl 7:143-176. doi: 10.1111/imj.15591. PMID: 34937136
Cadena J, Thompson GR 3rd, Patterson TF
Infect Dis Clin North Am 2021 Jun;35(2):415-434. doi: 10.1016/j.idc.2021.03.008. PMID: 34016284
Ullmann AJ, Aguado JM, Arikan-Akdagli S, Denning DW, Groll AH, Lagrou K, Lass-Flörl C, Lewis RE, Munoz P, Verweij PE, Warris A, Ader F, Akova M, Arendrup MC, Barnes RA, Beigelman-Aubry C, Blot S, Bouza E, Brüggemann RJM, Buchheidt D, Cadranel J, Castagnola E, Chakrabarti A, Cuenca-Estrella M, Dimopoulos G, Fortun J, Gangneux JP, Garbino J, Heinz WJ, Herbrecht R, Heussel CP, Kibbler CC, Klimko N, Kullberg BJ, Lange C, Lehrnbecher T, Löffler J, Lortholary O, Maertens J, Marchetti O, Meis JF, Pagano L, Ribaud P, Richardson M, Roilides E, Ruhnke M, Sanguinetti M, Sheppard DC, Sinkó J, Skiada A, Vehreschild MJGT, Viscoli C, Cornely OA
Clin Microbiol Infect 2018 May;24 Suppl 1:e1-e38. Epub 2018 Mar 12 doi: 10.1016/j.cmi.2018.01.002. PMID: 29544767
Moss RB
Clin Rev Allergy Immunol 2002 Aug;23(1):87-104. doi: 10.1385/CRIAI:23:1:087. PMID: 12162109

Diagnosis

Douglas AP, Smibert OC, Bajel A, Halliday CL, Lavee O, McMullan B, Yong MK, van Hal SJ, Chen SC; Australasian Antifungal Guidelines Steering Committee
Intern Med J 2021 Nov;51 Suppl 7:143-176. doi: 10.1111/imj.15591. PMID: 34937136
Cadena J, Thompson GR 3rd, Patterson TF
Infect Dis Clin North Am 2021 Jun;35(2):415-434. doi: 10.1016/j.idc.2021.03.008. PMID: 34016284
Latgé JP, Chamilos G
Clin Microbiol Rev 2019 Dec 18;33(1) Epub 2019 Nov 13 doi: 10.1128/CMR.00140-18. PMID: 31722890Free PMC Article
Husain S, Camargo JF
Clin Transplant 2019 Sep;33(9):e13544. Epub 2019 Apr 23 doi: 10.1111/ctr.13544. PMID: 30900296
Ullmann AJ, Aguado JM, Arikan-Akdagli S, Denning DW, Groll AH, Lagrou K, Lass-Flörl C, Lewis RE, Munoz P, Verweij PE, Warris A, Ader F, Akova M, Arendrup MC, Barnes RA, Beigelman-Aubry C, Blot S, Bouza E, Brüggemann RJM, Buchheidt D, Cadranel J, Castagnola E, Chakrabarti A, Cuenca-Estrella M, Dimopoulos G, Fortun J, Gangneux JP, Garbino J, Heinz WJ, Herbrecht R, Heussel CP, Kibbler CC, Klimko N, Kullberg BJ, Lange C, Lehrnbecher T, Löffler J, Lortholary O, Maertens J, Marchetti O, Meis JF, Pagano L, Ribaud P, Richardson M, Roilides E, Ruhnke M, Sanguinetti M, Sheppard DC, Sinkó J, Skiada A, Vehreschild MJGT, Viscoli C, Cornely OA
Clin Microbiol Infect 2018 May;24 Suppl 1:e1-e38. Epub 2018 Mar 12 doi: 10.1016/j.cmi.2018.01.002. PMID: 29544767

Therapy

Douglas AP, Smibert OC, Bajel A, Halliday CL, Lavee O, McMullan B, Yong MK, van Hal SJ, Chen SC; Australasian Antifungal Guidelines Steering Committee
Intern Med J 2021 Nov;51 Suppl 7:143-176. doi: 10.1111/imj.15591. PMID: 34937136
Cadena J, Thompson GR 3rd, Patterson TF
Infect Dis Clin North Am 2021 Jun;35(2):415-434. doi: 10.1016/j.idc.2021.03.008. PMID: 34016284
Latgé JP, Chamilos G
Clin Microbiol Rev 2019 Dec 18;33(1) Epub 2019 Nov 13 doi: 10.1128/CMR.00140-18. PMID: 31722890Free PMC Article
Husain S, Camargo JF
Clin Transplant 2019 Sep;33(9):e13544. Epub 2019 Apr 23 doi: 10.1111/ctr.13544. PMID: 30900296
Ullmann AJ, Aguado JM, Arikan-Akdagli S, Denning DW, Groll AH, Lagrou K, Lass-Flörl C, Lewis RE, Munoz P, Verweij PE, Warris A, Ader F, Akova M, Arendrup MC, Barnes RA, Beigelman-Aubry C, Blot S, Bouza E, Brüggemann RJM, Buchheidt D, Cadranel J, Castagnola E, Chakrabarti A, Cuenca-Estrella M, Dimopoulos G, Fortun J, Gangneux JP, Garbino J, Heinz WJ, Herbrecht R, Heussel CP, Kibbler CC, Klimko N, Kullberg BJ, Lange C, Lehrnbecher T, Löffler J, Lortholary O, Maertens J, Marchetti O, Meis JF, Pagano L, Ribaud P, Richardson M, Roilides E, Ruhnke M, Sanguinetti M, Sheppard DC, Sinkó J, Skiada A, Vehreschild MJGT, Viscoli C, Cornely OA
Clin Microbiol Infect 2018 May;24 Suppl 1:e1-e38. Epub 2018 Mar 12 doi: 10.1016/j.cmi.2018.01.002. PMID: 29544767

Prognosis

Husain S, Camargo JF
Clin Transplant 2019 Sep;33(9):e13544. Epub 2019 Apr 23 doi: 10.1111/ctr.13544. PMID: 30900296
Cunha C, Carvalho A
Med Mycol 2019 Apr 1;57(Supplement_2):S211-S218. doi: 10.1093/mmy/myy057. PMID: 30816966
Park SY, Yoon JA, Kim SH
Korean J Intern Med 2017 Sep;32(5):805-812. Epub 2017 Aug 24 doi: 10.3904/kjim.2017.109. PMID: 28835093Free PMC Article
Greenberger PA, Bush RK, Demain JG, Luong A, Slavin RG, Knutsen AP
J Allergy Clin Immunol Pract 2014 Nov-Dec;2(6):703-8. Epub 2014 Nov 6 doi: 10.1016/j.jaip.2014.08.007. PMID: 25439360Free PMC Article
Darveaux JI, Lemanske RF Jr
J Allergy Clin Immunol Pract 2014 Nov-Dec;2(6):658-63. Epub 2014 Nov 6 doi: 10.1016/j.jaip.2014.09.011. PMID: 25439354Free PMC Article

Clinical prediction guides

Singh A, Kaur A, Chowdhary A
Curr Opin Microbiol 2023 Oct;75:102365. Epub 2023 Aug 23 doi: 10.1016/j.mib.2023.102365. PMID: 37625261
Salazar F, Bignell E, Brown GD, Cook PC, Warris A
Clin Microbiol Rev 2022 Jan 19;35(1):e0009421. Epub 2021 Nov 17 doi: 10.1128/CMR.00094-21. PMID: 34788127Free PMC Article
Cadena J, Thompson GR 3rd, Patterson TF
Infect Dis Clin North Am 2021 Jun;35(2):415-434. doi: 10.1016/j.idc.2021.03.008. PMID: 34016284
Park SY, Yoon JA, Kim SH
Korean J Intern Med 2017 Sep;32(5):805-812. Epub 2017 Aug 24 doi: 10.3904/kjim.2017.109. PMID: 28835093Free PMC Article
Greenberger PA, Bush RK, Demain JG, Luong A, Slavin RG, Knutsen AP
J Allergy Clin Immunol Pract 2014 Nov-Dec;2(6):703-8. Epub 2014 Nov 6 doi: 10.1016/j.jaip.2014.08.007. PMID: 25439360Free PMC Article

Recent systematic reviews

Shi C, Shan Q, Xia J, Wang L, Wang L, Qiu L, Xie Y, Lin N, Wang L
Mycoses 2022 Feb;65(2):152-163. Epub 2021 Dec 22 doi: 10.1111/myc.13410. PMID: 34882852Free PMC Article
Lahmer T, Peçanha-Pietrobom PM, Schmid RM, Colombo AL
Mycoses 2022 Feb;65(2):140-151. Epub 2021 Dec 8 doi: 10.1111/myc.13403. PMID: 34837414
Bassetti M, Garnacho-Montero J, Calandra T, Kullberg B, Dimopoulos G, Azoulay E, Chakrabarti A, Kett D, Leon C, Ostrosky-Zeichner L, Sanguinetti M, Timsit JF, Richardson MD, Shorr A, Cornely OA
Intensive Care Med 2017 Sep;43(9):1225-1238. Epub 2017 Mar 2 doi: 10.1007/s00134-017-4731-2. PMID: 28255613
Gonzalez JM, Rodriguez CA, Agudelo M, Zuluaga AF, Vesga O
Braz J Infect Dis 2017 Jan-Feb;21(1):79-87. Epub 2016 Nov 5 doi: 10.1016/j.bjid.2016.09.009. PMID: 27821250Free PMC Article
Agarwal R, Khan A, Aggarwal AN, Gupta D
Mycoses 2012 Jul;55(4):357-65. Epub 2011 Oct 17 doi: 10.1111/j.1439-0507.2011.02130.x. PMID: 21999194

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