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TACO1 translational activator of cytochrome c oxidase I [ Homo sapiens (human) ]

Gene ID: 51204, updated on 23-Nov-2021

Summary

Official Symbol
TACO1provided by HGNC
Official Full Name
translational activator of cytochrome c oxidase Iprovided by HGNC
Primary source
HGNC:HGNC:24316
See related
Ensembl:ENSG00000136463 MIM:612958
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCDC44; MC4DN8
Summary
This gene encodes a mitochondrial protein that function as a translational activator of mitochondrially-encoded cytochrome c oxidase 1. Mutations in this gene are associated with Leigh syndrome.[provided by RefSeq, Mar 2010]
Expression
Ubiquitous expression in kidney (RPKM 17.5), liver (RPKM 13.0) and 25 other tissues See more
Orthologs
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Genomic context

See TACO1 in Genome Data Viewer
Location:
17q23.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (63600895..63608365)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (61678254..61685725)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily H member 6 Neighboring gene DDB1 and CUL4 associated factor 7 Neighboring gene RNA, U6 small nuclear 288, pseudogene Neighboring gene family with sequence similarity 136 member A pseudogene Neighboring gene mitogen-activated protein kinase kinase kinase 3 Neighboring gene eukaryotic translation elongation factor 1 delta pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mRNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mitochondrial ribosome binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables rRNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in mitochondrial cytochrome c oxidase assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in motor learning IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cytochrome-c oxidase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mitochondrial translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
translational activator of cytochrome c oxidase 1
Names
clone HQ0477 PRO0477p
coiled-coil domain-containing protein 44
translational activator of COX I
translational activator of mitochondrially encoded cytochrome c oxidase I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016979.1 RefSeqGene

    Range
    5024..12495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_016360.4NP_057444.2  translational activator of cytochrome c oxidase 1

    See identical proteins and their annotated locations for NP_057444.2

    Status: REVIEWED

    Source sequence(s)
    AK315375, BC005049
    Consensus CDS
    CCDS11640.1
    UniProtKB/Swiss-Prot
    Q9BSH4
    Related
    ENSP00000258975.6, ENST00000258975.7
    Conserved Domains (1) summary
    pfam01709
    Location:61296
    Transcrip_reg; Transcriptional regulator

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    63600895..63608365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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