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Taco1 translational activator of mitochondrially encoded cytochrome c oxidase I [ Mus musculus (house mouse) ]

Gene ID: 70207, updated on 26-Sep-2022

Summary

Official Symbol
Taco1provided by MGI
Official Full Name
translational activator of mitochondrially encoded cytochrome c oxidase Iprovided by MGI
Primary source
MGI:MGI:1917457
See related
Ensembl:ENSMUSG00000001983 AllianceGenome:MGI:1917457
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccdc44; 2310066I18Rik
Summary
Enables mRNA binding activity; mitochondrial ribosome binding activity; and rRNA binding activity. Acts upstream of or within several processes, including mitochondrial cytochrome c oxidase assembly; motor learning; and regulation of cytochrome-c oxidase activity. Located in mitochondrion. Is expressed in several structures, including alimentary system; nervous system; nose; orbito-sphenoid; and pharyngo-tympanic tube. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human TACO1 (translational activator of cytochrome c oxidase I). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 10.7), kidney adult (RPKM 7.0) and 28 other tissues See more
Orthologs
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Genomic context

See Taco1 in Genome Data Viewer
Location:
11; 11 E1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (105956885..105964861)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (106066057..106074035)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35971 Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 6 Neighboring gene DDB1 and CUL4 associated factor 7 Neighboring gene translational activator of mitochondrially encoded cytochrome c oxidase I, opposite strand Neighboring gene mitogen-activated protein kinase kinase kinase 3 Neighboring gene predicted gene 10840 Neighboring gene LIM domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mitochondrial ribosome binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables rRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
translational activator of cytochrome c oxidase 1
Names
coiled-coil domain-containing protein 44
translational activator of mitochondrially-encoded cytochrome c oxidase 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027346.2NP_081622.1  translational activator of cytochrome c oxidase 1

    See identical proteins and their annotated locations for NP_081622.1

    Status: VALIDATED

    Source sequence(s)
    AK047078, AW491435
    Consensus CDS
    CCDS25547.1
    UniProtKB/Swiss-Prot
    Q8K0Z7, Q9CV09
    Related
    ENSMUSP00000002048.8, ENSMUST00000002048.8
    Conserved Domains (1) summary
    pfam01709
    Location:58293
    Transcrip_reg; Transcriptional regulator

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    105956885..105964861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156974.1XP_036012867.1  translational activator of cytochrome c oxidase 1 isoform X1

    Conserved Domains (1) summary
    pfam01709
    Location:58169
    Transcrip_reg; Transcriptional regulator