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HSPA14 heat shock protein family A (Hsp70) member 14 [ Homo sapiens (human) ]

Gene ID: 51182, updated on 2-Nov-2024

Summary

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Official Symbol
HSPA14provided by HGNC
Official Full Name
heat shock protein family A (Hsp70) member 14provided by HGNC
Primary source
HGNC:HGNC:29526
See related
Ensembl:ENSG00000187522 MIM:610369; AllianceGenome:HGNC:29526
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSP70-4; HSP70L1; MSANTD7
Summary
Predicted to enable ATP hydrolysis activity; heat shock protein binding activity; and protein folding chaperone. Predicted to be involved in chaperone cofactor-dependent protein refolding and protein refolding. Located in cytosol and ribosome. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis (RPKM 8.1), bone marrow (RPKM 6.5) and 25 other tissues See more
Orthologs
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Genomic context

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See HSPA14 in Genome Data Viewer
Location:
10p13
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (14838306..14871741)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (14852271..14885706)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (14880305..14913740)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 107 member B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:14779811-14780332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3083 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3084 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:14793464-14794381 Neighboring gene ribosomal protein SA pseudogene 7 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3085 Neighboring gene Myb/SANT DNA binding domain containing 7 Neighboring gene cerebral dopamine neurotrophic factor Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2164 Neighboring gene SUV39H2 divergent transcript Neighboring gene NANOG hESC enhancer GRCh37_chr10:14946352-14947052 Neighboring gene SUV39H2 histone lysine methyltransferase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3086 Neighboring gene DNA cross-link repair 1C Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3087 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:14994732-14995460 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:14995461-14996188 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2166 Neighboring gene meiosis/spermiogenesis associated 1 Neighboring gene olfactory receptor family 7 subfamily E member 110 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression of HSPA14 in patients with acute HIV-1 infection and its effect on HIV-1 replication. Bi M, et al. Front Immunol, 2023. PMID 36845091, Free PMC Article
  2. Intracellular HSP70L1 inhibits human dendritic cell maturation by promoting suppressive H3K27me3 and H2AK119Ub1 histone modifications. Yi L, et al. Cell Mol Immunol, 2020 Jan. PMID 30635648, Free PMC Article
  3. Novel heat shock protein Hsp70L1 activates dendritic cells and acts as a Th1 polarizing adjuvant. Wan T, et al. Blood, 2004 Mar 1. PMID 14592822
  4. Telomerase promotes formation of a telomere protective complex in cancer cells. Perera ON, et al. Sci Adv, 2019 Oct. PMID 31616780, Free PMC Article
  5. Induction of HSPA4 and HSPA14 by NBS1 overexpression contributes to NBS1-induced in vitro metastatic and transformation activity. Wu CY, et al. J Biomed Sci, 2011 Jan 6. PMID 21208456, Free PMC Article

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of HSPA14 in patients with acute HIV-1 infection and its effect on HIV-1 replication.
    Title: Expression of HSPA14 in patients with acute HIV-1 infection and its effect on HIV-1 replication.
  2. Intracellular HSP70L1 inhibits human dendritic cell maturation by promoting suppressive H3K27me3 and H2AK119Ub1 histone modifications.
    Title: Intracellular HSP70L1 inhibits human dendritic cell maturation by promoting suppressive H3K27me3 and H2AK119Ub1 histone modifications.
  3. HSP70L1 expression is induced by TERT.TERT promotes formation of a telomere protective complex containing Hsp70L1.
    Title: Telomerase promotes formation of a telomere protective complex in cancer cells.
  4. TLR4 is a key receptor mediating the interaction of Hsp70L1 with DCs and subsequently enhancing the induction of Th1 immune response by Hsp70L1/antigen fusion protein
    Title: Toll-like receptor 4 (TLR4) is essential for Hsp70-like protein 1 (HSP70L1) to activate dendritic cells and induce Th1 response.
  5. a novel pathway (NBS1-HSF4b-HSPA4/HSPA14 axis) to induce migration, invasion, and transformation, suggesting the activation of multiple signaling events induced by NBS1 overexpression
    Title: Induction of HSPA4 and HSPA14 by NBS1 overexpression contributes to NBS1-induced in vitro metastatic and transformation activity.
  6. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer.
  7. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
    Title: Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants.
  8. results demonstrate that Hsp70L1 has enhanced Th1 polarizing and adjuvant properties, which appear to be mediated via activation of dendritic cells
    Title: Novel heat shock protein Hsp70L1 activates dendritic cells and acts as a Th1 polarizing adjuvant.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of heat shock 70kDa protein 14 (HSPA14) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Over expression of hsp70 with a herpes viral amplicon vector protects cultured hippocampal rat neurons from gp120 neurotoxicity PubMed
env The exposure of permissive CD4+ cells to HIV-1 gp120 increases the synthesis and nuclear translocation of 70kDa heat shock protein PubMed
Pr55(Gag) gag Hsp70 co-sediments with HIV-1 capsid protein in sucrose density gradients, providing evidence that it is specifically incorporated into HIV-1 virions through an interaction with HIV-1 Gag proteins PubMed
gag Hsp70 is incorporated into HIV-1 virions through an interaction with HIV-1 Gag PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC131990

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in 'de novo' cotranslational protein folding TAS
Traceable Author Statement
more info
 PubMed 
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 
colocalizes_with ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with ribosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
heat shock 70 kDa protein 14
Names
HSP70-like protein 1
heat shock protein HSP60
heat shock protein family A member 14
heat shock protein hsp70-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016299.4 → NP_057383.2  heat shock 70 kDa protein 14

    See identical proteins and their annotated locations for NP_057383.2

    Status: VALIDATED

    Source sequence(s)
    AF112210, BC119690, BP201211
    Consensus CDS
    CCDS7103.1
    UniProtKB/Swiss-Prot
    A8K8F8, B0YIY9, Q0VDF9, Q9P0X2, Q9UI07
    Related
    ENSP00000367623.3, ENST00000378372.8
    Conserved Domains (1) summary
    cd10238
    Location:2 → 376
    HSPA14-like_NBD; Nucleotide-binding domain of human HSPA14 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    14838306..14871741
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    14852271..14885706
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001037538.1: Suppressed sequence

    Description
    NM_001037538.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

  2. NM_001278205.1: Suppressed sequence

    Description
    NM_001278205.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.

  3. NR_103464.2: Suppressed sequence

    Description
    NR_103464.2: This RefSeq was removed because it is thought that this transcript better represents a distinct gene, GeneID: 100421372.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A1W2PQ72.1 GenPept UniProtKB/Swiss-Prot:A0A1W2PQ72
Q0VDF9.1 GenPept UniProtKB/Swiss-Prot:Q0VDF9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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