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HSPA14 heat shock protein family A (Hsp70) member 14 [ Homo sapiens (human) ]

Gene ID: 51182, updated on 2-Oct-2018

Summary

Official Symbol
HSPA14provided by HGNC
Official Full Name
heat shock protein family A (Hsp70) member 14provided by HGNC
Primary source
HGNC:HGNC:29526
See related
Ensembl:ENSG00000187522 Ensembl:ENSG00000284024 MIM:610369; Vega:OTTHUMG00000191882
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSP70-4; HSP70L1
Expression
Ubiquitous expression in testis (RPKM 8.1), bone marrow (RPKM 6.5) and 25 other tissues See more
Orthologs

Genomic context

See HSPA14 in Genome Data Viewer
Location:
10p13
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (14838160..14871741)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (14880159..14913740)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 107 member B Neighboring gene ribosomal protein SA pseudogene 7 Neighboring gene zinc finger and SCAN domain containing 29 pseudogene Neighboring gene cerebral dopamine neurotrophic factor Neighboring gene suppressor of variegation 3-9 homolog 2 Neighboring gene DNA cross-link repair 1C Neighboring gene meiosis/spermiogenesis associated 1 Neighboring gene olfactory receptor family 7 subfamily E member 110 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of heat shock 70kDa protein 14 (HSPA14) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Over expression of hsp70 with a herpes viral amplicon vector protects cultured hippocampal rat neurons from gp120 neurotoxicity PubMed
env The exposure of permissive CD4+ cells to HIV-1 gp120 increases the synthesis and nuclear translocation of 70kDa heat shock protein PubMed
Pr55(Gag) gag Hsp70 co-sediments with HIV-1 capsid protein in sucrose density gradients, providing evidence that it is specifically incorporated into HIV-1 virions through an interaction with HIV-1 Gag proteins PubMed
gag Hsp70 is incorporated into HIV-1 virions through an interaction with HIV-1 Gag PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC131990

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase activity, coupled IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding involved in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
'de novo' cotranslational protein folding TAS
Traceable Author Statement
more info
PubMed 
cellular response to heat IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to unfolded protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of translational fidelity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to unfolded protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
polysome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with ribosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
heat shock 70 kDa protein 14
Names
HSP70-like protein 1
heat shock 70kDa protein 14 isoform 1 variant 3
heat shock protein HSP60
heat shock protein hsp70-related protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278205.1NP_001265134.1  heat shock 70 kDa protein 14 isoform 3

    See identical proteins and their annotated locations for NP_001265134.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 3' exon in place of the last several exons compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC026226, BC038845, BP201211
    Consensus CDS
    CCDS60487.1
    UniProtKB/TrEMBL
    B0YIZ1, Q8TAQ0
    Related
    ENSP00000390513.2, OTTHUMP00000019162, ENST00000437161.7, OTTHUMT00000046912
    Conserved Domains (1) summary
    cl17037
    Location:274
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  2. NM_016299.3NP_057383.2  heat shock 70 kDa protein 14 isoform 1

    See identical proteins and their annotated locations for NP_057383.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AF112210, BC119690, BP201211
    Consensus CDS
    CCDS7103.1
    UniProtKB/Swiss-Prot
    Q0VDF9
    Related
    ENSP00000367623.3, OTTHUMP00000019161, ENST00000378372.7, OTTHUMT00000046910
    Conserved Domains (1) summary
    cd10238
    Location:2376
    HSPA14-like_NBD; Nucleotide-binding domain of human HSPA14 and similar proteins

RNA

  1. NR_103464.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains two alternate 3' exons in place of the last several exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC026226, BC108738, BP201211
    Related
    ENST00000640019.2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    14838160..14871741
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001037538.1: Suppressed sequence

    Description
    NM_001037538.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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