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DCTN4 dynactin subunit 4 [ Homo sapiens (human) ]

Gene ID: 51164, updated on 17-Jun-2019

Summary

Official Symbol
DCTN4provided by HGNC
Official Full Name
dynactin subunit 4provided by HGNC
Primary source
HGNC:HGNC:15518
See related
Ensembl:ENSG00000132912 MIM:614758
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P62; DYN4
Expression
Ubiquitous expression in brain (RPKM 24.6), bone marrow (RPKM 19.3) and 25 other tissues See more
Orthologs

Genomic context

See DCTN4 in Genome Data Viewer
Location:
5q33.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (150708747..150759095, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (150088309..150138657, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene myozenin 3 Neighboring gene RNA binding motif protein 22 Neighboring gene small integral membrane protein 3 Neighboring gene immunity related GTPase M Neighboring gene zinc finger protein 300

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Asparagine N-linked glycosylation, organism-specific biosystem (from REACTOME)
    Asparagine N-linked glycosylation, organism-specific biosystemN-linked glycosylation is the most important form of post-translational modification for proteins synthesized and folded in the Endoplasmic Reticulum (Stanley et al. 2009). An early study in 1999 rev...
  • COPI-independent Golgi-to-ER retrograde traffic, organism-specific biosystem (from REACTOME)
    COPI-independent Golgi-to-ER retrograde traffic, organism-specific biosystemIn addition to the better characterized COPI-dependent retrograde Golgi-to-ER pathway, a second COPI-independent pathway has also been identified. This pathway is RAB6 dependent and transports cargo...
  • COPI-mediated anterograde transport, organism-specific biosystem (from REACTOME)
    COPI-mediated anterograde transport, organism-specific biosystemThe ERGIC (ER-to-Golgi intermediate compartment, also known as vesicular-tubular clusters, VTCs) is a stable, biochemically distinct compartment located adjacent to ER exit sites (Ben-Tekaya et al, 2...
  • ER to Golgi Anterograde Transport, organism-specific biosystem (from REACTOME)
    ER to Golgi Anterograde Transport, organism-specific biosystemSecretory cargo destined to be secreted or to arrive at the plasma membrane (PM) leaves the ER via distinct exit sites. This cargo is destined for the Golgi apparatus for further processing.
  • Golgi-to-ER retrograde transport, organism-specific biosystem (from REACTOME)
    Golgi-to-ER retrograde transport, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER occurs through either COPI-coated vesicles or through a less well characterized RAB6-dependent route that makes use of tubular carriers (r...
  • Huntington's disease, organism-specific biosystem (from KEGG)
    Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • Huntington's disease, conserved biosystem (from KEGG)
    Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
    Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
  • MHC class II antigen presentation, organism-specific biosystem (from REACTOME)
    MHC class II antigen presentation, organism-specific biosystemAntigen presenting cells (APCs) such as B cells, dendritic cells (DCs) and monocytes/macrophages express major histocompatibility complex class II molecules (MHC II) at their surface and present exog...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Transport to the Golgi and subsequent modification, organism-specific biosystem (from REACTOME)
    Transport to the Golgi and subsequent modification, organism-specific biosystemAt least two mechanisms of transport of proteins from the ER to the Golgi have been described. One is a general flow requiring no export signals (Wieland et al, 1987; Martinez-Menarguez et al, 1999)....
  • Vasopressin-regulated water reabsorption, organism-specific biosystem (from KEGG)
    Vasopressin-regulated water reabsorption, organism-specific biosystemIn the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adju...
  • Vasopressin-regulated water reabsorption, conserved biosystem (from KEGG)
    Vasopressin-regulated water reabsorption, conserved biosystemIn the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adju...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
Traceable Author Statement
more info
 
nuclear migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell cortex IEA
Inferred from Electronic Annotation
more info
 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dynactin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
focal adhesion IEA
Inferred from Electronic Annotation
more info
 
kinetochore IEA
Inferred from Electronic Annotation
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
sarcomere IEA
Inferred from Electronic Annotation
more info
 
spindle pole IEA
Inferred from Electronic Annotation
more info
 
stress fiber IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dynactin subunit 4
Names
dynactin 4 (p62)
dynactin p62 subunit
dynactin subunit p62

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135643.1NP_001129115.1  dynactin subunit 4 isoform a

    See identical proteins and their annotated locations for NP_001129115.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK307757, AL162085, DC321382
    Consensus CDS
    CCDS47310.1
    UniProtKB/Swiss-Prot
    Q9UJW0
    UniProtKB/TrEMBL
    Q9NSJ5
    Related
    ENSP00000414906.2, ENST00000446090.6
    Conserved Domains (1) summary
    pfam05502
    Location:23348
    Dynactin_p62; Dynactin p62 family
  2. NM_001135644.1NP_001129116.1  dynactin subunit 4 isoform c

    See identical proteins and their annotated locations for NP_001129116.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus and lacks a 7 aa internal segment compared to isoform a.
    Source sequence(s)
    AC008450, AK125973, AL162085
    Consensus CDS
    CCDS47311.1
    UniProtKB/Swiss-Prot
    Q9UJW0
    UniProtKB/TrEMBL
    Q9NSJ5
    Related
    ENSP00000411251.1, ENST00000424236.5
    Conserved Domains (1) summary
    pfam05502
    Location:2284
    Dynactin_p62; Dynactin p62 family
  3. NM_016221.3NP_057305.1  dynactin subunit 4 isoform b

    See identical proteins and their annotated locations for NP_057305.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AK000299, AL162085, DC321382
    Consensus CDS
    CCDS4310.1
    UniProtKB/Swiss-Prot
    Q9UJW0
    UniProtKB/TrEMBL
    A0A0S2Z5D4, Q9NSJ5
    Related
    ENSP00000416968.2, ENST00000447998.6
    Conserved Domains (1) summary
    pfam05502
    Location:23341
    Dynactin_p62; Dynactin p62 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    150708747..150759095 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537646.1XP_011535948.1  dynactin subunit 4 isoform X2

    Conserved Domains (1) summary
    pfam05502
    Location:164262
    Dynactin_p62; Dynactin p62 family
  2. XM_005268457.1XP_005268514.1  dynactin subunit 4 isoform X3

    See identical proteins and their annotated locations for XP_005268514.1

    Conserved Domains (1) summary
    pfam05502
    Location:100198
    Dynactin_p62; Dynactin p62 family
  3. XM_011537644.1XP_011535946.1  dynactin subunit 4 isoform X1

    See identical proteins and their annotated locations for XP_011535946.1

    UniProtKB/Swiss-Prot
    Q9UJW0
    Conserved Domains (1) summary
    pfam05502
    Location:2284
    Dynactin_p62; Dynactin p62 family
  4. XM_011537647.1XP_011535949.1  dynactin subunit 4 isoform X3

    See identical proteins and their annotated locations for XP_011535949.1

    Conserved Domains (1) summary
    pfam05502
    Location:100198
    Dynactin_p62; Dynactin p62 family
  5. XM_011537645.1XP_011535947.1  dynactin subunit 4 isoform X1

    See identical proteins and their annotated locations for XP_011535947.1

    UniProtKB/Swiss-Prot
    Q9UJW0
    Conserved Domains (1) summary
    pfam05502
    Location:2284
    Dynactin_p62; Dynactin p62 family
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