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Dctn4 dynactin 4 [ Mus musculus (house mouse) ]

Gene ID: 67665, updated on 30-Apr-2024

Summary

Official Symbol
Dctn4provided by MGI
Official Full Name
dynactin 4provided by MGI
Primary source
MGI:MGI:1914915
See related
Ensembl:ENSMUSG00000024603 AllianceGenome:MGI:1914915
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p62; 1110001K06Rik; 4930547K17Rik; C130039E17Rik
Summary
Predicted to enable protein N-terminus binding activity. Predicted to be located in centrosome; kinetochore; and spindle pole. Predicted to be part of cytoplasmic dynein complex and dynactin complex. Predicted to colocalize with focal adhesion and stress fiber. Is expressed in cerebral cortex. Orthologous to human DCTN4 (dynactin subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 20.0), whole brain E14.5 (RPKM 18.4) and 28 other tissues See more
Orthologs
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Genomic context

See Dctn4 in Genome Data Viewer
Location:
18 D3; 18 34.36 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (60659226..60691838)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (60526154..60558766)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44715 Neighboring gene small integral membrane protein 3 Neighboring gene predicted gene, 46628 Neighboring gene STARR-positive B cell enhancer ABC_E9978 Neighboring gene predicted gene, 52358 Neighboring gene RNA binding motif protein 22 Neighboring gene myozenin 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
part_of cytoplasmic dynein complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
part_of dynactin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with stress fiber ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dynactin subunit 4
Names
dynactin subunit p62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357462.1NP_001344391.1  dynactin subunit 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC135638, AK034292, AK160813, BB856653, CJ308131
    Consensus CDS
    CCDS89246.1
    UniProtKB/Swiss-Prot
    Q8CBY8, Q923A0, Q9D4X0
    Related
    ENSMUSP00000153008.2, ENSMUST00000223984.2
    Conserved Domains (1) summary
    pfam05502
    Location:23348
    Dynactin_p62; Dynactin p62 family
  2. NM_026302.4NP_080578.1  dynactin subunit 4 isoform 1

    See identical proteins and their annotated locations for NP_080578.1

    Status: VALIDATED

    Source sequence(s)
    AC135638, AK160813, AK163240, BB856653, CJ308131
    Consensus CDS
    CCDS37832.1
    UniProtKB/TrEMBL
    Q3TQY2
    Related
    ENSMUSP00000025505.6, ENSMUST00000025505.7
    Conserved Domains (1) summary
    pfam05502
    Location:23341
    Dynactin_p62; Dynactin p62 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    60659226..60691838
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)