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ANGPTL4 angiopoietin like 4 [ Homo sapiens (human) ]

Gene ID: 51129, updated on 10-Mar-2024

Summary

Official Symbol
ANGPTL4provided by HGNC
Official Full Name
angiopoietin like 4provided by HGNC
Primary source
HGNC:HGNC:16039
See related
Ensembl:ENSG00000167772 MIM:605910; AllianceGenome:HGNC:16039
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NL2; ARP4; FIAF; HARP; PGAR; HFARP; TGQTL; UNQ171; pp1158
Summary
This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013]
Expression
Broad expression in liver (RPKM 42.4), fat (RPKM 23.7) and 17 other tissues See more
Orthologs
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Genomic context

See ANGPTL4 in Genome Data Viewer
Location:
19p13.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (8364155..8374370)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (8350623..8360841)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (8429039..8439254)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8387283-8388248 Neighboring gene ribosomal protein S28 Neighboring gene KN motif and ankyrin repeat domains 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10016 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10017 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10018 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10019 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8405154-8405654 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8407589-8408380 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13914 Neighboring gene RAB11B antisense RNA 1 Neighboring gene uncharacterized LOC124904632 Neighboring gene microRNA 4999

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Plasma triglyceride level quantitative trait locus
MedGen: C4014553 OMIM: 615881 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Biological, clinical and population relevance of 95 loci for blood lipids.
EBI GWAS Catalog
Common variants at 30 loci contribute to polygenic dyslipidemia.
EBI GWAS Catalog
Discovery and refinement of loci associated with lipid levels.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables enzyme inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables enzyme inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in endothelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of endothelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of lipoprotein lipase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of angiogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in protein unfolding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to hypoxia NAS
Non-traceable Author Statement
more info
PubMed 
involved_in triglyceride homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in triglyceride homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in blood microparticle HDA PubMed 
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
angiopoietin-related protein 4
Names
PPARG angiopoietin related protein
fasting-induced adipose factor
hepatic angiopoietin-related protein
hepatic fibrinogen/angiopoietin-related protein
peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012169.1 RefSeqGene

    Range
    5029..15244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001039667.3NP_001034756.1  angiopoietin-related protein 4 isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AF202636, BP397348
    Consensus CDS
    CCDS42493.1
    UniProtKB/Swiss-Prot
    Q9BY76
    Related
    ENSP00000377534.1, ENST00000393962.6
    Conserved Domains (1) summary
    cd00087
    Location:184362
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
  2. NM_139314.3NP_647475.1  angiopoietin-related protein 4 isoform a precursor

    See identical proteins and their annotated locations for NP_647475.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AF202636, BP397348
    Consensus CDS
    CCDS12200.1
    UniProtKB/Swiss-Prot
    A8MY84, B4E089, D6W670, F5H0I2, Q53HQ6, Q53HU1, Q6UXN0, Q9BY76, Q9HBV4, Q9NZU4, Q9Y5B3
    Related
    ENSP00000301455.1, ENST00000301455.7
    Conserved Domains (1) summary
    cd00087
    Location:183400
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RNA

  1. NR_104213.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks four internal exons and uses an alternate splice site in the 3' exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AC136469

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    8364155..8374370
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005272484.4XP_005272541.1  angiopoietin-related protein 4 isoform X1

    Conserved Domains (1) summary
    cd00087
    Location:183418
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
  2. XM_005272485.4XP_005272542.1  angiopoietin-related protein 4 isoform X2

    Conserved Domains (1) summary
    cd00087
    Location:184380
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    8350623..8360841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321146.1XP_054177121.1  angiopoietin-related protein 4 isoform X1

  2. XM_054321147.1XP_054177122.1  angiopoietin-related protein 4 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016109.2: Suppressed sequence

    Description
    NM_016109.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.