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Angptl4 angiopoietin-like 4 [ Mus musculus (house mouse) ]

Gene ID: 57875, updated on 1-Mar-2024

Summary

Official Symbol
Angptl4provided by MGI
Official Full Name
angiopoietin-like 4provided by MGI
Primary source
MGI:MGI:1888999
See related
Ensembl:ENSMUSG00000002289 AllianceGenome:MGI:1888999
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Arp4; Bk89; Fiaf; Ng27; Pgar; Hfarp; Pgarg; Pp1158
Summary
Enables enzyme inhibitor activity. Involved in negative regulation of apoptotic process; negative regulation of lipoprotein lipase activity; and triglyceride homeostasis. Acts upstream of or within negative regulation of endothelial cell apoptotic process. Located in extracellular space. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; integumental system; and musculature. Orthologous to human ANGPTL4 (angiopoietin like 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 130.4), genital fat pad adult (RPKM 109.0) and 14 other tissues See more
Orthologs
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Genomic context

See Angptl4 in Genome Data Viewer
Location:
17 B1; 17 17.98 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (33993874..34000549, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33774900..33781575, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene membrane associated ring-CH-type finger 2 Neighboring gene STARR-positive B cell enhancer ABC_E7520 Neighboring gene RAB11B, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E82 Neighboring gene RAB11B, member RAS oncogene family, opposite strand 1 Neighboring gene predicted gene, 53997 Neighboring gene STARR-seq mESC enhancer starr_42411 Neighboring gene STARR-positive B cell enhancer ABC_E956 Neighboring gene STARR-positive B cell enhancer ABC_E2482 Neighboring gene KN motif and ankyrin repeat domains 3 Neighboring gene ribosomal protein S28

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables enzyme inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
angiopoietin-related protein 4
Names
425O18-1
angiopoietin-like protein 4
fasting-induced adipose factor
fibrinogen/angiopoietin-related protein
hepatic fibrinogen/angiopoietin-related protein
major histocompatibility complex region NG27
secreted protein Bk89

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020581.2NP_065606.2  angiopoietin-related protein 4 precursor

    See identical proteins and their annotated locations for NP_065606.2

    Status: VALIDATED

    Source sequence(s)
    AK014564, AW495750, BY783212
    Consensus CDS
    CCDS28629.1
    UniProtKB/Swiss-Prot
    Q78ZJ9, Q9JHX7, Q9JLX7, Q9Z1P8
    UniProtKB/TrEMBL
    A0A068BEP2
    Related
    ENSMUSP00000002360.10, ENSMUST00000002360.17
    Conserved Domains (2) summary
    cd00087
    Location:187404
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    pfam08702
    Location:104133
    Fib_alpha; Fibrinogen alpha/beta chain family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    33993874..34000549 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)