U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

COMMD2 COMM domain containing 2 [ Homo sapiens (human) ]

Gene ID: 51122, updated on 26-Jan-2024

Summary

Official Symbol
COMMD2provided by HGNC
Official Full Name
COMM domain containing 2provided by HGNC
Primary source
HGNC:HGNC:24993
See related
Ensembl:ENSG00000114744 MIM:616699; AllianceGenome:HGNC:24993
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSPC042
Summary
Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 7.0), lung (RPKM 6.4) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See COMMD2 in Genome Data Viewer
Location:
3q25.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (149738472..149752489, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (152489726..152503742, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (149456259..149470276, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene WW domain containing transcription regulator 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:149369611-149370110 Neighboring gene Sharpr-MPRA regulatory region 14320 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:149375639-149376218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20682 Neighboring gene WWTR1 intronic transcript 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:149388438-149388978 Neighboring gene WWTR1 antisense RNA 1 Neighboring gene NANOG hESC enhancer GRCh37_chr3:149396068-149396569 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:149431193-149431694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:149431695-149432194 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14807 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:149508028-149509227 Neighboring gene RNA, U6 small nuclear 507, pseudogene Neighboring gene ankyrin repeat and ubiquitin domain containing 1 Neighboring gene Sharpr-MPRA regulatory region 5490 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:149530359-149530870 Neighboring gene MPRA-validated peak4858 silencer Neighboring gene ring finger protein 13 Neighboring gene RNA, U6 small nuclear 720, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC57611

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
COMM domain-containing protein 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016094.4NP_057178.2  COMM domain-containing protein 2

    See identical proteins and their annotated locations for NP_057178.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the supported protein.
    Source sequence(s)
    AK055223, BC001228, BC022206, BU633168, DA811158
    Consensus CDS
    CCDS3145.1
    UniProtKB/Swiss-Prot
    Q561V4, Q86X83, Q9H3L5, Q9Y5V1
    Related
    ENSP00000419475.1, ENST00000473414.6
    Conserved Domains (1) summary
    cd04750
    Location:26190
    Commd2; COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...

RNA

  1. NR_135149.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC069216, BG700015, BU633168, CN483677

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    149738472..149752489 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448244.1XP_047304200.1  COMM domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    F8WBW1
    Related
    ENSP00000417962.1, ENST00000491617.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    152489726..152503742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346720.1XP_054202695.1  COMM domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    F8WBW1