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COMMD2 COMM domain containing 2 [ Homo sapiens (human) ]

Gene ID: 51122, updated on 8-Aug-2021

Summary

Official Symbol
COMMD2provided by HGNC
Official Full Name
COMM domain containing 2provided by HGNC
Primary source
HGNC:HGNC:24993
See related
Ensembl:ENSG00000114744 MIM:616699
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSPC042
Expression
Ubiquitous expression in thyroid (RPKM 7.0), lung (RPKM 6.4) and 25 other tissues See more
Orthologs
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Genomic context

See COMMD2 in Genome Data Viewer
Location:
3q25.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (149738472..149752489, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (149456259..149470276, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1098, pseudogene Neighboring gene WW domain containing transcription regulator 1 Neighboring gene WWTR1 antisense RNA 1 Neighboring gene ankyrin repeat and ubiquitin domain containing 1 Neighboring gene RNA, U6 small nuclear 507, pseudogene Neighboring gene ring finger protein 13 Neighboring gene RNA, U6 small nuclear 720, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC57611

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
COMM domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016094.4NP_057178.2  COMM domain-containing protein 2

    See identical proteins and their annotated locations for NP_057178.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the supported protein.
    Source sequence(s)
    AK055223, BC001228, BC022206, BU633168, DA811158
    Consensus CDS
    CCDS3145.1
    UniProtKB/Swiss-Prot
    Q86X83
    Related
    ENSP00000419475.1, ENST00000473414.6
    Conserved Domains (1) summary
    cd04750
    Location:26190
    Commd2; COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...

RNA

  1. NR_135149.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC069216, BG700015, BU633168, CN483677

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    149738472..149752489 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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