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MRPS2 mitochondrial ribosomal protein S2 [ Homo sapiens (human) ]

Gene ID: 51116, updated on 4-Oct-2020

Summary

Official Symbol
MRPS2provided by HGNC
Official Full Name
mitochondrial ribosomal protein S2provided by HGNC
Primary source
HGNC:HGNC:14495
See related
Ensembl:ENSG00000122140 MIM:611971
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S2mt; CGI-91; MRP-S2; COXPD36
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S2 family. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
Expression
Ubiquitous expression in kidney (RPKM 13.4), ovary (RPKM 10.7) and 25 other tissues See more
Orthologs

Genomic context

See MRPS2 in Genome Data Viewer
Location:
9q34.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (135499965..135504673)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (138392477..138396519)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 regulatory subunit 26 Neighboring gene chromosome 9 open reading frame 116 Neighboring gene uncharacterized LOC101928525 Neighboring gene lipocalin 1 Neighboring gene odorant binding protein 2A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
mitochondrial ribosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrial translation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial small ribosomal subunit ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
28S ribosomal protein S2, mitochondrial
Names
mitochondrial small ribosomal subunit protein uS2m

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042313.1 RefSeqGene

    Range
    5052..9041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001371401.1NP_001358330.1  28S ribosomal protein S2, mitochondrial

    Status: REVIEWED

    Source sequence(s)
    AL161452
    Related
    ENSP00000360850.1, ENST00000371785.5
    Conserved Domains (1) summary
    cd01425
    Location:84259
    RPS2; Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of ...
  2. NM_016034.5NP_057118.1  28S ribosomal protein S2, mitochondrial

    See identical proteins and their annotated locations for NP_057118.1

    Status: REVIEWED

    Source sequence(s)
    BQ065672, BX362434
    Consensus CDS
    CCDS6990.1
    UniProtKB/Swiss-Prot
    Q9Y399
    Related
    ENSP00000241600.5, ENST00000241600.10
    Conserved Domains (1) summary
    cd01425
    Location:84259
    RPS2; Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of ...

RNA

  1. NR_051967.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL161452
  2. NR_051968.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL161452
  3. NR_051969.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL161452
  4. NR_051970.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL161452

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    135499965..135504673
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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