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LACTB2 lactamase beta 2 [ Homo sapiens (human) ]

Gene ID: 51110, updated on 24-Nov-2021

Summary

Official Symbol
LACTB2provided by HGNC
Official Full Name
lactamase beta 2provided by HGNC
Primary source
HGNC:HGNC:18512
See related
Ensembl:ENSG00000147592 MIM:618921
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI-83
Expression
Broad expression in testis (RPKM 25.7), kidney (RPKM 23.4) and 24 other tissues See more
Orthologs
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Genomic context

See LACTB2 in Genome Data Viewer
Location:
8q13.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (70637266..70669185, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (71549501..71581420, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375890 Neighboring gene LACTB2 antisense RNA 1 Neighboring gene translocation associated membrane protein 1 Neighboring gene RNA, 7SL, cytoplasmic 19, pseudogene Neighboring gene XK related 9 Neighboring gene uncharacterized LOC105375894 Neighboring gene EYA transcriptional coactivator and phosphatase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables endoribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables endoribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables single-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA phosphodiester bond hydrolysis, endonucleolytic IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
endoribonuclease LACTB2
Names
beta-lactamase-like protein 2
testicular secretory protein Li 23
NP_057111.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016027.3NP_057111.1  endoribonuclease LACTB2

    See identical proteins and their annotated locations for NP_057111.1

    Status: VALIDATED

    Source sequence(s)
    AC022731, AF151841, DB445101
    Consensus CDS
    CCDS6208.1
    UniProtKB/Swiss-Prot
    Q53H82
    UniProtKB/TrEMBL
    A0A024R811
    Related
    ENSP00000276590.4, ENST00000276590.5
    Conserved Domains (1) summary
    cd07722
    Location:14203
    LACTB2-like_MBL-fold; uncharacterized subgroup which includes human lactamase beta 2 and related proteins; MBL-fold metallo hydrolase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    70637266..70669185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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