U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lactb2 lactamase, beta 2 [ Mus musculus (house mouse) ]

Gene ID: 212442, updated on 11-Mar-2023

Summary

Go to the top of the page Help
Official Symbol
Lactb2provided by MGI
Official Full Name
lactamase, beta 2provided by MGI
Primary source
MGI:MGI:2442551
See related
Ensembl:ENSMUSG00000025937 AllianceGenome:MGI:2442551
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cgi-83; E430032H21Rik
Summary
Predicted to enable endoribonuclease activity; single-stranded RNA binding activity; and zinc ion binding activity. Predicted to be involved in RNA phosphodiester bond hydrolysis, endonucleolytic. Located in mitochondrion. Is expressed in brain ventricular layer; liver lobe; lung; renal cortex; and submandibular gland primordium. Orthologous to human LACTB2 (lactamase beta 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 64.2), liver adult (RPKM 44.6) and 15 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Lactb2 in Genome Data Viewer
Location:
1; 1 A3
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (13696117..13731424, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (13625893..13660583, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39600 Neighboring gene translocating chain-associating membrane protein 1 Neighboring gene X-linked Kx blood group related 9 Neighboring gene predicted gene, 26273

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A novel transgenic line of mice exhibiting autosomal recessive male-specific lethality and non-alcoholic fatty liver disease. Sollars VE, et al. Hum Mol Genet, 2002 Oct 15. PMID 12374767
  2. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
  3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (19) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC7674

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables RNA endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables single-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA phosphodiester bond hydrolysis, endonucleolytic ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
endoribonuclease LACTB2
Names
beta-lactamase-like protein 2
NP_663356.1
XP_006495553.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417630.1 → NP_001404559.1  endoribonuclease LACTB2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC116708

  2. NM_001417633.1 → NP_001404562.1  endoribonuclease LACTB2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC116708

  3. NM_001417634.1 → NP_001404563.1  endoribonuclease LACTB2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC116708

  4. NM_001417635.1 → NP_001404564.1  endoribonuclease LACTB2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC116708

  5. NM_001417636.1 → NP_001404565.1  endoribonuclease LACTB2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC116708

  6. NM_145381.3 → NP_663356.1  endoribonuclease LACTB2 isoform 1

    See identical proteins and their annotated locations for NP_663356.1

    Status: VALIDATED

    Source sequence(s)
    AC116708
    Consensus CDS
    CCDS14823.1
    UniProtKB/Swiss-Prot
    Q99KR3
    Related
    ENSMUSP00000027071.6, ENSMUST00000027071.7
    Conserved Domains (2) summary
    COG0491
    Location:23 → 223
    GloB; Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II [General function prediction only]
    cd07722
    Location:14 → 203
    LACTB2-like_MBL-fold; uncharacterized subgroup which includes human lactamase beta 2 and related proteins; MBL-fold metallo hydrolase domain

RNA

  1. NR_184544.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116708

  2. NR_184545.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116708

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    13696117..13731424 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495490.5 → XP_006495553.1  endoribonuclease LACTB2 isoform X1

    Conserved Domains (1) summary
    cd07722
    Location:14 → 203
    LACTB2-like_MBL-fold; uncharacterized subgroup which includes human lactamase beta 2 and related proteins; MBL-fold metallo hydrolase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99KR3.1 GenPept UniProtKB/Swiss-Prot:Q99KR3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous