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FCF1 FCF1 rRNA-processing protein [ Homo sapiens (human) ]

Gene ID: 51077, updated on 21-Mar-2023

Summary

Official Symbol
FCF1provided by HGNC
Official Full Name
FCF1 rRNA-processing proteinprovided by HGNC
Primary source
HGNC:HGNC:20220
See related
Ensembl:ENSG00000119616 AllianceGenome:HGNC:20220
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Bka; UTP24; CGI-35; C14orf111
Summary
Enables RNA binding activity. Predicted to be involved in rRNA processing. Predicted to act upstream of or within endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleoplasm. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 6.5), colon (RPKM 5.1) and 25 other tissues See more
Orthologs
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Genomic context

See FCF1 in Genome Data Viewer
Location:
14q24.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (74713144..74738620)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (68922243..68947721)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (75179847..75205323)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2 pseudogene Neighboring gene apoptosis resistant E3 ubiquitin protein ligase 1 Neighboring gene YLP motif containing 1 Neighboring gene uncharacterized LOC105370569

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC99629

General protein information

Preferred Names
rRNA-processing protein FCF1 homolog
Names
FCF1 small subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318508.2NP_001305437.1  rRNA-processing protein FCF1 homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC007956
    Consensus CDS
    CCDS81827.1
    UniProtKB/TrEMBL
    G3V1S4
    Related
    ENSP00000444939.2, ENST00000534938.6
    Conserved Domains (1) summary
    cd09864
    Location:45175
    PIN_Fcf1-like; VapC-like PIN domain of rRNA-processing protein, Fcf1 (Utp24, YDR339C), and other eukaryotic homologs
  2. NM_015962.5NP_057046.1  rRNA-processing protein FCF1 homolog isoform 1

    See identical proteins and their annotated locations for NP_057046.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC007956, BX489015, BX647810
    Consensus CDS
    CCDS9832.1
    UniProtKB/Swiss-Prot
    Q8TBL8, Q9Y324
    UniProtKB/TrEMBL
    Q4FZ45
    Related
    ENSP00000344393.4, ENST00000341162.8
    Conserved Domains (1) summary
    cd09864
    Location:57187
    PIN_Fcf1-like; VapC-like PIN domain of rRNA-processing protein, Fcf1 (Utp24, YDR339C), and other eukaryotic homologs

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    74713144..74738620
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536816.4XP_011535118.1  rRNA-processing protein FCF1 homolog isoform X2

    Conserved Domains (1) summary
    cd09864
    Location:19153
    PIN_Fcf1; PIN domain of rRNA-processing protein, Fcf1 (Utp24, YDR339C), and other eukaryotic homologs
  2. XM_011536815.4XP_011535117.1  rRNA-processing protein FCF1 homolog isoform X1

    See identical proteins and their annotated locations for XP_011535117.1

    Conserved Domains (1) summary
    cd09864
    Location:33163
    PIN_Fcf1-like; VapC-like PIN domain of rRNA-processing protein, Fcf1 (Utp24, YDR339C), and other eukaryotic homologs

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    68922243..68947721
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376168.1XP_054232143.1  rRNA-processing protein FCF1 homolog isoform X2

  2. XM_054376167.1XP_054232142.1  rRNA-processing protein FCF1 homolog isoform X1