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MEMO1 mediator of cell motility 1 [ Homo sapiens (human) ]

Gene ID: 51072, updated on 8-Jul-2019

Summary

Official Symbol
MEMO1provided by HGNC
Official Full Name
mediator of cell motility 1provided by HGNC
Primary source
HGNC:HGNC:14014
See related
Ensembl:ENSG00000162959 MIM:611786
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MEMO; C2orf4; CGI-27; NS5ATP7
Expression
Broad expression in testis (RPKM 22.5), bone marrow (RPKM 10.2) and 24 other tissues See more
Orthologs

Genomic context

See MEMO1 in Genome Data Viewer
Location:
2p22.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (31865060..32011052, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (32092892..32236116, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene keratin 18 pseudogene 52 Neighboring gene adenylate kinase 2 pseudogene 2 Neighboring gene dpy-30 histone methyltransferase complex regulatory subunit Neighboring gene spastin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • ERBB2 Regulates Cell Motility, organism-specific biosystem (from REACTOME)
    ERBB2 Regulates Cell Motility, organism-specific biosystemActivated ERBB2 heterodimers regulate cell motility through association with MEMO1. MEMO1 retains activated RHOA GTPase and its associated protein DIAPH1 at the plasma membrane, thus linking ERBB2 ac...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by ERBB2, organism-specific biosystem (from REACTOME)
    Signaling by ERBB2, organism-specific biosystemERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25031, DKFZp434I0135

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of cell motility TAS
Traceable Author Statement
more info
 
regulation of microtubule-based process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol HDA PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 

General protein information

Preferred Names
protein MEMO1
Names
C21orf19-like protein
HCV NS5A-transactivated protein 7
hepatitis C virus NS5A-transactivated protein 7
mediator of ErbB2-driven cell motility 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001137602.2NP_001131074.1  protein MEMO1 isoform 2

    See identical proteins and their annotated locations for NP_001131074.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB041018, AK297128, BU628425
    Consensus CDS
    CCDS46255.1
    UniProtKB/Swiss-Prot
    Q9Y316
    Related
    ENSP00000400795.2, ENST00000426310.6
    Conserved Domains (1) summary
    cd07361
    Location:9271
    MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility
  2. NM_001301833.2NP_001288762.1  protein MEMO1 isoform 1

    See identical proteins and their annotated locations for NP_001288762.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AB041018, AK290753, AL121652, BU628425
    Consensus CDS
    CCDS1776.1
    UniProtKB/Swiss-Prot
    Q9Y316
    UniProtKB/TrEMBL
    A8K3Y8
    Related
    ENSP00000385557.1, ENST00000404530.5
    Conserved Domains (1) summary
    cd07361
    Location:9294
    MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility
  3. NM_001301852.2NP_001288781.1  protein MEMO1 isoform 3

    See identical proteins and their annotated locations for NP_001288781.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, has multiple coding region differences, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AB041018, AL121652, BG033287, BP248979, BU628425
    UniProtKB/Swiss-Prot
    Q9Y316
    Conserved Domains (1) summary
    cl00599
    Location:114198
    Extradiol_Dioxygenase_3B_like; Subunit B of Class III Extradiol ring-cleavage dioxygenases
  4. NM_015955.3NP_057039.1  protein MEMO1 isoform 1

    See identical proteins and their annotated locations for NP_057039.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Both variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AB041018, BU628425
    Consensus CDS
    CCDS1776.1
    UniProtKB/Swiss-Prot
    Q9Y316
    Related
    ENSP00000295065.4, ENST00000295065.9
    Conserved Domains (1) summary
    cd07361
    Location:9294
    MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility

RNA

  1. NR_126032.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two consecutive internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB041018, BU628425, CD250945
  2. NR_126034.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains an alternate 5' terminal exon and lacks multiple alternate internal exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AB041018, AK057760, AL121652, BU628425

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    31865060..32011052 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452944.1XP_024308712.1  protein MEMO1 isoform X3

    Conserved Domains (1) summary
    cl00599
    Location:114198
    Extradiol_Dioxygenase_3B_like; Subunit B of Class III Extradiol ring-cleavage dioxygenases
  2. XM_011532896.2XP_011531198.1  protein MEMO1 isoform X3

    See identical proteins and their annotated locations for XP_011531198.1

    Conserved Domains (1) summary
    cl00599
    Location:114198
    Extradiol_Dioxygenase_3B_like; Subunit B of Class III Extradiol ring-cleavage dioxygenases
  3. XM_024452943.1XP_024308711.1  protein MEMO1 isoform X2

    Conserved Domains (1) summary
    cd07361
    Location:9271
    MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility
  4. XM_011532892.2XP_011531194.1  protein MEMO1 isoform X1

    See identical proteins and their annotated locations for XP_011531194.1

    UniProtKB/Swiss-Prot
    Q9Y316
    Conserved Domains (1) summary
    cd07361
    Location:9294
    MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility
  5. XM_017004255.1XP_016859744.1  protein MEMO1 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y316
    Related
    ENSP00000368691.3, ENST00000379383.7
    Conserved Domains (1) summary
    cd07361
    Location:9294
    MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility
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