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FAM135B family with sequence similarity 135 member B [ Homo sapiens (human) ]

Gene ID: 51059, updated on 23-Nov-2021

Summary

Official Symbol
FAM135Bprovided by HGNC
Official Full Name
family with sequence similarity 135 member Bprovided by HGNC
Primary source
HGNC:HGNC:28029
See related
Ensembl:ENSG00000147724
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C8ORFK32
Expression
Biased expression in testis (RPKM 3.0), brain (RPKM 2.6) and 4 other tissues See more
Orthologs
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Genomic context

See FAM135B in Genome Data Viewer
Location:
8q24.23
Exon count:
30
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (138130023..138497730, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (139142266..139509973, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375776 Neighboring gene uncharacterized LOC401478 Neighboring gene collagen type XXII alpha 1 chain Neighboring gene Sharpr-MPRA regulatory region 3511

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network.
GeneReviews: Not available
Common genetic variation and performance on standardized cognitive tests.
GeneReviews: Not available
Genome-wide association study of chronic periodontitis in a general German population.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33221, MGC126009, MGC126010

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cellular lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362965.2NP_001349894.1  protein FAM135B

    Status: VALIDATED

    Source sequence(s)
    AC068467, AC103777, AK091433, BC037288, BX110118, H05729
    Consensus CDS
    CCDS6375.2
    Conserved Domains (2) summary
    pfam05057
    Location:11361330
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111170
    DUF3657; Protein FAM135
  2. NM_015912.4NP_056996.2  protein FAM135B

    See identical proteins and their annotated locations for NP_056996.2

    Status: VALIDATED

    Source sequence(s)
    AC068467, AC103777, AK091433, BC037288, BX110118
    Consensus CDS
    CCDS6375.2
    UniProtKB/Swiss-Prot
    Q49AJ0
    Related
    ENSP00000378710.1, ENST00000395297.6
    Conserved Domains (2) summary
    pfam05057
    Location:11361330
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111170
    DUF3657; Protein FAM135

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    138130023..138497730 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517062.1XP_011515364.1  protein FAM135B isoform X1

    See identical proteins and their annotated locations for XP_011515364.1

    Conserved Domains (2) summary
    pfam05057
    Location:11401334
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111170
    DUF3657; Protein FAM135
  2. XM_011517061.2XP_011515363.1  protein FAM135B isoform X1

    See identical proteins and their annotated locations for XP_011515363.1

    Conserved Domains (2) summary
    pfam05057
    Location:11401334
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111170
    DUF3657; Protein FAM135
  3. XM_011517063.2XP_011515365.1  protein FAM135B isoform X1

    See identical proteins and their annotated locations for XP_011515365.1

    Conserved Domains (2) summary
    pfam05057
    Location:11401334
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111170
    DUF3657; Protein FAM135
  4. XM_011517060.2XP_011515362.1  protein FAM135B isoform X1

    See identical proteins and their annotated locations for XP_011515362.1

    Conserved Domains (2) summary
    pfam05057
    Location:11401334
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111170
    DUF3657; Protein FAM135
  5. XM_011517058.2XP_011515360.1  protein FAM135B isoform X1

    See identical proteins and their annotated locations for XP_011515360.1

    Conserved Domains (2) summary
    pfam05057
    Location:11401334
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111170
    DUF3657; Protein FAM135
  6. XM_017013471.1XP_016868960.1  protein FAM135B isoform X4

  7. XM_011517056.2XP_011515358.1  protein FAM135B isoform X1

    See identical proteins and their annotated locations for XP_011515358.1

    Conserved Domains (2) summary
    pfam05057
    Location:11401334
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111170
    DUF3657; Protein FAM135
  8. XM_011517064.2XP_011515366.1  protein FAM135B isoform X2

    See identical proteins and their annotated locations for XP_011515366.1

    UniProtKB/Swiss-Prot
    Q49AJ0
    Conserved Domains (2) summary
    pfam05057
    Location:11361330
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111170
    DUF3657; Protein FAM135
  9. XM_011517059.1XP_011515361.1  protein FAM135B isoform X1

    See identical proteins and their annotated locations for XP_011515361.1

    Conserved Domains (2) summary
    pfam05057
    Location:11401334
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111170
    DUF3657; Protein FAM135
  10. XM_011517065.1XP_011515367.1  protein FAM135B isoform X3

    Conserved Domains (2) summary
    pfam05057
    Location:11241318
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:95154
    DUF3657; Protein of unknown function (DUF3657)
  11. XM_011517068.2XP_011515370.1  protein FAM135B isoform X5

    UniProtKB/Swiss-Prot
    Q49AJ0
    Conserved Domains (2) summary
    pfam05057
    Location:10371231
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:1271
    DUF3657; Protein of unknown function (DUF3657)
  12. XM_011517069.2XP_011515371.1  protein FAM135B isoform X6

    Conserved Domains (1) summary
    pfam05057
    Location:10181212
    DUF676; Putative serine esterase (DUF676)
  13. XM_011517072.2XP_011515374.1  protein FAM135B isoform X8

    Conserved Domains (1) summary
    pfam05057
    Location:9391133
    DUF676; Putative serine esterase (DUF676)
  14. XM_011517073.2XP_011515375.1  protein FAM135B isoform X9

    Conserved Domains (1) summary
    pfam05057
    Location:9071101
    DUF676; Putative serine esterase (DUF676)
  15. XM_011517074.1XP_011515376.1  protein FAM135B isoform X10

    Conserved Domains (1) summary
    pfam05057
    Location:8911085
    DUF676; Putative serine esterase (DUF676)
  16. XM_011517070.2XP_011515372.1  protein FAM135B isoform X7

    Related
    ENSP00000276737.6, ENST00000276737.10
    Conserved Domains (2) summary
    pfam05057
    Location:11401216
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111170
    DUF3657; Protein of unknown function (DUF3657)

RNA

  1. XR_001745532.1 RNA Sequence

  2. XR_001745531.1 RNA Sequence

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