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FAM135B family with sequence similarity 135 member B [ Homo sapiens (human) ]

Gene ID: 51059, updated on 12-Mar-2017
Official Symbol
FAM135Bprovided by HGNC
Official Full Name
family with sequence similarity 135 member Bprovided by HGNC
Primary source
HGNC:HGNC:28029
See related
Ensembl:ENSG00000147724 Vega:OTTHUMG00000149864
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C8ORFK32
Orthologs
Location:
8q24.23
Exon count:
30
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 8 NC_000008.11 (138130023..138498390, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (139142266..139509065, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375776 Neighboring gene uncharacterized LOC401478 Neighboring gene collagen type XXII alpha 1 chain Neighboring gene uncharacterized LOC105375777 Neighboring gene potassium two pore domain channel subfamily K member 9

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

NHGRI GWAS Catalog

Description
A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network.
NHGRI GWA Catalog
Common genetic variation and performance on standardized cognitive tests.
NHGRI GWA Catalog
Genome-wide association study of chronic periodontitis in a general German population.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC33221, MGC126009, MGC126010

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carboxylic ester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
cellular lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015912.3NP_056996.2  protein FAM135B

    See identical proteins and their annotated locations for NP_056996.2

    Status: VALIDATED

    Source sequence(s)
    AC103777, AK091433, BC037288, BX110118
    Consensus CDS
    CCDS6375.2
    UniProtKB/Swiss-Prot
    Q49AJ0
    Related
    ENSP00000378710, OTTHUMP00000194814, ENST00000395297, OTTHUMT00000313590
    Conserved Domains (2) summary
    pfam05057
    Location:11361330
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111170
    DUF3657; Protein of unknown function (DUF3657)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p7 Primary Assembly

    Range
    138130023..138498390 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013470.1XP_016868959.1  protein FAM135B isoform X2

    UniProtKB/Swiss-Prot
    Q49AJ0
    Conserved Domains (2) summary
    pfam05057
    Location:11361330
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111170
    DUF3657; Protein of unknown function (DUF3657)
  2. XM_011517062.1XP_011515364.1  protein FAM135B isoform X1

    See identical proteins and their annotated locations for XP_011515364.1

    Conserved Domains (2) summary
    pfam05057
    Location:11401334
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111170
    DUF3657; Protein of unknown function (DUF3657)
  3. XM_011517061.2XP_011515363.1  protein FAM135B isoform X1

    See identical proteins and their annotated locations for XP_011515363.1

    Conserved Domains (2) summary
    pfam05057
    Location:11401334
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111170
    DUF3657; Protein of unknown function (DUF3657)
  4. XM_011517063.2XP_011515365.1  protein FAM135B isoform X1

    See identical proteins and their annotated locations for XP_011515365.1

    Conserved Domains (2) summary
    pfam05057
    Location:11401334
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111170
    DUF3657; Protein of unknown function (DUF3657)
  5. XM_011517060.2XP_011515362.1  protein FAM135B isoform X1

    See identical proteins and their annotated locations for XP_011515362.1

    Conserved Domains (2) summary
    pfam05057
    Location:11401334
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111170
    DUF3657; Protein of unknown function (DUF3657)
  6. XM_011517058.2XP_011515360.1  protein FAM135B isoform X1

    See identical proteins and their annotated locations for XP_011515360.1

    Conserved Domains (2) summary
    pfam05057
    Location:11401334
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111170
    DUF3657; Protein of unknown function (DUF3657)
  7. XM_017013471.1XP_016868960.1  protein FAM135B isoform X4

  8. XM_011517056.2XP_011515358.1  protein FAM135B isoform X1

    See identical proteins and their annotated locations for XP_011515358.1

    Conserved Domains (2) summary
    pfam05057
    Location:11401334
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111170
    DUF3657; Protein of unknown function (DUF3657)
  9. XM_011517064.2XP_011515366.1  protein FAM135B isoform X2

    See identical proteins and their annotated locations for XP_011515366.1

    UniProtKB/Swiss-Prot
    Q49AJ0
    Conserved Domains (2) summary
    pfam05057
    Location:11361330
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111170
    DUF3657; Protein of unknown function (DUF3657)
  10. XM_011517059.1XP_011515361.1  protein FAM135B isoform X1

    See identical proteins and their annotated locations for XP_011515361.1

    Conserved Domains (2) summary
    pfam05057
    Location:11401334
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111170
    DUF3657; Protein of unknown function (DUF3657)
  11. XM_011517065.1XP_011515367.1  protein FAM135B isoform X3

    Conserved Domains (2) summary
    pfam05057
    Location:11241318
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:95154
    DUF3657; Protein of unknown function (DUF3657)
  12. XM_011517068.2XP_011515370.1  protein FAM135B isoform X5

    UniProtKB/Swiss-Prot
    Q49AJ0
    Conserved Domains (2) summary
    pfam05057
    Location:10371231
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:1271
    DUF3657; Protein of unknown function (DUF3657)
  13. XM_011517069.2XP_011515371.1  protein FAM135B isoform X6

    Conserved Domains (1) summary
    pfam05057
    Location:10181212
    DUF676; Putative serine esterase (DUF676)
  14. XM_011517072.2XP_011515374.1  protein FAM135B isoform X8

    Conserved Domains (1) summary
    pfam05057
    Location:9391133
    DUF676; Putative serine esterase (DUF676)
  15. XM_011517073.2XP_011515375.1  protein FAM135B isoform X9

    Conserved Domains (1) summary
    pfam05057
    Location:9071101
    DUF676; Putative serine esterase (DUF676)
  16. XM_011517074.1XP_011515376.1  protein FAM135B isoform X10

    Conserved Domains (1) summary
    pfam05057
    Location:8911085
    DUF676; Putative serine esterase (DUF676)
  17. XM_011517070.2XP_011515372.1  protein FAM135B isoform X7

    Related
    ENSP00000276737, OTTHUMP00000226104, ENST00000276737, OTTHUMT00000313589
    Conserved Domains (2) summary
    pfam05057
    Location:11401216
    DUF676; Putative serine esterase (DUF676)
    pfam12394
    Location:111170
    DUF3657; Protein of unknown function (DUF3657)

RNA

  1. XR_001745532.1 RNA Sequence

  2. XR_001745531.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    139182500..139549298 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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