Format

Send to:

Choose Destination

ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 [ Homo sapiens (human) ]

Gene ID: 51046, updated on 4-May-2020

Summary

Official Symbol
ST8SIA3provided by HGNC
Official Full Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3provided by HGNC
Primary source
HGNC:HGNC:14269
See related
Ensembl:ENSG00000177511 MIM:609478
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIAT8C; ST8SiaIII
Summary
ST8SIA3 belongs to a family of sialyltransferases that form sialyl-alpha-2,8-sialyl-R linkages at the nonreducing termini of glycoconjugates (Lee et al., 1998 [PubMed 9826427]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in brain (RPKM 16.9) and adrenal (RPKM 2.9) See more
Orthologs

Genomic context

See ST8SIA3 in Genome Data Viewer
Location:
18q21.31
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (57352557..57368931)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (55019721..55036162)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2565 Neighboring gene RNA, U6 small nuclear 737, pseudogene Neighboring gene uncharacterized LOC112267870 Neighboring gene FOXA motif-containing MPRA enhancer 78 Neighboring gene one cut homeobox 2 Neighboring gene ferrochelatase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sialic acid binding IC
Inferred by Curator
more info
PubMed 
sialyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
N-glycan processing IDA
Inferred from Direct Assay
more info
PubMed 
ganglioside biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
glycoprotein metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
glycosphingolipid biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oligosaccharide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein glycosylation IDA
Inferred from Direct Assay
more info
PubMed 
protein glycosylation IEA
Inferred from Electronic Annotation
more info
 
protein sialylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase
Names
SIAT8-C
ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 3
alpha-2,8-sialyltransferase 8C
alpha-2,8-sialyltransferase III
sialyltransferase 8C (alpha2,3Galbeta1,4GlcNAcalpha 2,8-sialyltransferase)
sialyltransferase St8Sia III
sialytransferase St8Sia III
NP_056963.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015879.3NP_056963.2  sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase

    See identical proteins and their annotated locations for NP_056963.2

    Status: VALIDATED

    Source sequence(s)
    AB208996, AC090208
    Consensus CDS
    CCDS32834.1
    UniProtKB/Swiss-Prot
    O43173
    UniProtKB/TrEMBL
    Q59GW3
    Related
    ENSP00000320431.2, ENST00000324000.4
    Conserved Domains (1) summary
    pfam00777
    Location:113376
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    57352557..57368931
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center