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ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 [ Homo sapiens (human) ]

Gene ID: 51046, updated on 12-May-2024

Summary

Official Symbol
ST8SIA3provided by HGNC
Official Full Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3provided by HGNC
Primary source
HGNC:HGNC:14269
See related
Ensembl:ENSG00000177511 MIM:609478; AllianceGenome:HGNC:14269
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIAT8C; ST8SiaIII
Summary
Enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity and identical protein binding activity. Involved in several processes, including ganglioside biosynthetic process; glycoprotein metabolic process; and protein sialylation. Predicted to be located in Golgi membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 16.9) and adrenal (RPKM 2.9) See more
Orthologs
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Genomic context

See ST8SIA3 in Genome Data Viewer
Location:
18q21.31
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (57352557..57368931)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (57553442..57569818)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (55019788..55036162)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2565 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr18:54877070-54878269 Neighboring gene RNA, U6 small nuclear 737, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9477 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:55101332-55101912 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:55101913-55102492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9478 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:55104607-55105362 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:55106119-55106874 Neighboring gene FOXA motif-containing MPRA enhancer 78 Neighboring gene one cut homeobox 2 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_48194 and experimental_48198 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_48219 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_48245 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13369 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13370 Neighboring gene MPRA-validated peak3163 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr18:55230082-55230255 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13371 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13372 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13373 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9479 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9481 Neighboring gene ferrochelatase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in N-glycan processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ganglioside biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glycoprotein metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glycosphingolipid biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
involved_in oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in oligosaccharide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein glycosylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
 
involved_in sialylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sialylation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in Golgi membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3
Names
SIAT8-C
ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 3
alpha-2,8-sialyltransferase 8C
alpha-2,8-sialyltransferase III
ganglioside GD3 synthase ST8SIA3
hST8Sia III
sia-a2,3-Gal-b1,4-Glc-NAc-R:a2,8-sialyltransferase
sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase
sialyltransferase 8C (alpha2,3Galbeta1,4GlcNAcalpha 2,8-sialyltransferase)
sialyltransferase St8Sia III
sialytransferase St8Sia III
NP_056963.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015879.3NP_056963.2  alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3

    See identical proteins and their annotated locations for NP_056963.2

    Status: VALIDATED

    Source sequence(s)
    AB208996, AC090208
    Consensus CDS
    CCDS32834.1
    UniProtKB/Swiss-Prot
    A8K0F2, O43173, Q6B085, Q9NS41
    Related
    ENSP00000320431.2, ENST00000324000.4
    Conserved Domains (1) summary
    pfam00777
    Location:113376
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    57352557..57368931
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    57553442..57569818
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)