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St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 [ Mus musculus (house mouse) ]

Gene ID: 20451, updated on 18-Feb-2023

Summary

Official Symbol
St8sia3provided by MGI
Official Full Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3provided by MGI
Primary source
MGI:MGI:106019
See related
Ensembl:ENSMUSG00000056812 AllianceGenome:MGI:106019
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Siat8c; ST8SiaIII
Summary
Enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. Predicted to be involved in several processes, including ganglioside biosynthetic process; glycoprotein metabolic process; and protein sialylation. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Is expressed in brain and testis. Orthologous to human ST8SIA3 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 10.9), CNS E18 (RPKM 10.3) and 8 other tissues See more
Orthologs
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Genomic context

See St8sia3 in Genome Data Viewer
Location:
18; 18 E1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (64387430..64409217)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (64254359..64276146)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3, opposite strand Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 pseudogene Neighboring gene peroxiredoxin 1, pseudogene 1 Neighboring gene ribosomal protein S15, pseudogene 3 Neighboring gene one cut domain, family member 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in N-glycan processing ISO
Inferred from Sequence Orthology
more info
 
involved_in ganglioside biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glycoprotein metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in oligosaccharide metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein glycosylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein sialylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sialylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase
Names
SIAT8-C
alpha-2,8-sialyltransferase 8C
alpha-2,8-sialyltransferase III
sialyltransferase 8 (alpha-2, 8-sialyltransferase) C
sialyltransferase 8C
sialyltransferase St8Sia III
sialytransferase St8Sia III
NP_033208.2
XP_030106227.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009182.3NP_033208.2  sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase

    See identical proteins and their annotated locations for NP_033208.2

    Status: VALIDATED

    Source sequence(s)
    AK015874, BB616760, BC075645
    Consensus CDS
    CCDS29301.1
    UniProtKB/Swiss-Prot
    Q64689, Q6DIB7
    UniProtKB/TrEMBL
    A0A8C6GJC5, Q9CUJ6
    Related
    ENSMUSP00000025477.8, ENSMUST00000025477.15
    Conserved Domains (1) summary
    pfam00777
    Location:113376
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    64387430..64409217
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250367.2XP_030106227.1  sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q6DIB7
    UniProtKB/TrEMBL
    A0A8C6GJC5
    Related
    ENSMUSP00000158392.2, ENSMUST00000237770.2
    Conserved Domains (1) summary
    pfam00777
    Location:113376
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)