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HDDC2 HD domain containing 2 [ Homo sapiens (human) ]

Gene ID: 51020, updated on 21-Dec-2019

Summary

Official Symbol
HDDC2provided by HGNC
Official Full Name
HD domain containing 2provided by HGNC
Primary source
HGNC:HGNC:21078
See related
Ensembl:ENSG00000111906
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C6orf74; CGI-130; NS5ATP2; dJ167O5.2
Expression
Ubiquitous expression in adrenal (RPKM 20.8), brain (RPKM 17.5) and 25 other tissues See more
Orthologs

Genomic context

See HDDC2 in Genome Data Viewer
Location:
6q22.31
Exon count:
8
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (125275350..125302066, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (125596496..125623287, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RNF217 antisense RNA 1 (head to head) Neighboring gene ring finger protein 217 Neighboring gene TPD52 like 1 Neighboring gene uncharacterized LOC100126584 Neighboring gene CRISPRi-validated cis-regulatory element chr6.4553 Neighboring gene CRISPRi-validated cis-regulatory element chr6.4554

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol HIV-1 IN is identified to have a physical interaction with HD domain containing 2 (HDDC2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC87330

Gene Ontology Provided by GOA

Function Evidence Code Pubs
5'-deoxynucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
HD domain-containing protein 2
Names
HCV NS5A-transactivated protein 2
hepatitis C virus NS5A-transactivated protein 2
testicular tissue protein Li 83

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016063.3NP_057147.2  HD domain-containing protein 2

    See identical proteins and their annotated locations for NP_057147.2

    Status: VALIDATED

    Source sequence(s)
    AL121938, BE743302, BP257644, DB447428
    Consensus CDS
    CCDS43503.1
    UniProtKB/Swiss-Prot
    Q7Z4H3
    UniProtKB/TrEMBL
    A0A140VJK7
    Related
    ENSP00000381220.1, ENST00000398153.7
    Conserved Domains (1) summary
    pfam13023
    Location:24183
    HD_3; HD domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    125275350..125302066 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446450.1XP_024302218.1  HD domain-containing protein 2 isoform X1

    Conserved Domains (1) summary
    cl21469
    Location:1131
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

RNA

  1. XR_245538.4 RNA Sequence

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