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Olig1 oligodendrocyte transcription factor 1 [ Mus musculus (house mouse) ]

Gene ID: 50914, updated on 11-Jun-2024

Summary

Official Symbol
Olig1provided by MGI
Official Full Name
oligodendrocyte transcription factor 1provided by MGI
Primary source
MGI:MGI:1355334
See related
Ensembl:ENSMUSG00000046160 AllianceGenome:MGI:1355334
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Olg-1; Bhlhb6; Oligo1; bHLHe21
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in oligodendrocyte development. Acts upstream of or within neuron fate commitment. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; early conceptus; embryo mesenchyme; and sensory organ. Orthologous to human OLIG1 (oligodendrocyte transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Olig1 in Genome Data Viewer
Location:
16 C3.3; 16 52.67 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (91066657..91068827)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (91269769..91271939)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41492 Neighboring gene STARR-seq mESC enhancer starr_41474 Neighboring gene predicted gene, 53920 Neighboring gene oligodendrocyte transcription factor 2 Neighboring gene predicted gene, 52261 Neighboring gene STARR-seq mESC enhancer starr_41475 Neighboring gene STARR-seq mESC enhancer starr_41476 Neighboring gene STARR-positive B cell enhancer ABC_E5559 Neighboring gene STARR-positive B cell enhancer ABC_E4189 Neighboring gene predicted gene, 24695 Neighboring gene predicted gene, 36587 Neighboring gene interferon (alpha and beta) receptor 2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables E-box binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in axon development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neuron fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in oligodendrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in sensory organ development IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transcription regulator complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
oligodendrocyte transcription factor 1
Names
oligodendrocyte-specific bHLH transcription factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016968.4NP_058664.2  oligodendrocyte transcription factor 1

    See identical proteins and their annotated locations for NP_058664.2

    Status: VALIDATED

    Source sequence(s)
    BB867931, BC046316, BQ713413, BU531317
    Consensus CDS
    CCDS28324.1
    UniProtKB/Swiss-Prot
    Q9JKN5
    UniProtKB/TrEMBL
    Q3UN59
    Related
    ENSMUSP00000061408.6, ENSMUST00000056882.7
    Conserved Domains (1) summary
    pfam00010
    Location:96153
    HLH; Helix-loop-helix DNA-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    91066657..91068827
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)