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Tmod2 tropomodulin 2 [ Mus musculus (house mouse) ]

Gene ID: 50876, updated on 5-Mar-2024

Summary

Official Symbol
Tmod2provided by MGI
Official Full Name
tropomodulin 2provided by MGI
Primary source
MGI:MGI:1355335
See related
Ensembl:ENSMUSG00000032186 AllianceGenome:MGI:1355335
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NTMOD; N-Tmod
Summary
Predicted to enable actin binding activity and tropomyosin binding activity. Acts upstream of or within learning or memory; neuron-neuron synaptic transmission; and positive regulation of G protein-coupled receptor signaling pathway. Predicted to be located in growth cone. Predicted to be active in striated muscle thin filament. Is expressed in several structures, including adrenal gland; cardiovascular system; genitourinary system; gut; and nervous system. Orthologous to human TMOD2 (tropomodulin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 26.5), cortex adult (RPKM 21.6) and 9 other tissues See more
Orthologs
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Genomic context

See Tmod2 in Genome Data Viewer
Location:
9 D; 9 42.31 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (75472903..75518620, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (75565621..75611342, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7972 Neighboring gene tropomodulin 3 Neighboring gene STARR-positive B cell enhancer mm9_chr9:75407347-75407647 Neighboring gene STARR-positive B cell enhancer mm9_chr9:75429888-75430189 Neighboring gene STARR-positive B cell enhancer mm9_chr9:75478519-75478819 Neighboring gene LysM, putative peptidoglycan-binding, domain containing 2 Neighboring gene secretogranin III

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables tropomyosin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables tropomyosin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within learning or memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in myofibril assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within neuron-neuron synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pointed-end actin filament capping IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
is_active_in myofibril IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in striated muscle thin filament IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
tropomodulin-2
Names
neural tropomodulin
neuronal tropomodulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038710.1NP_001033799.1  tropomodulin-2

    See identical proteins and their annotated locations for NP_001033799.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    AC123832, AK079077, BC052227
    Consensus CDS
    CCDS23345.1
    UniProtKB/Swiss-Prot
    Q3UH50, Q8BGX9, Q9CUK4, Q9JKK7, Q9JLH9
    Related
    ENSMUSP00000150750.2, ENSMUST00000215036.2
    Conserved Domains (2) summary
    pfam03250
    Location:5146
    Tropomodulin
    cl39015
    Location:215323
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  2. NM_016711.3NP_057920.2  tropomodulin-2

    See identical proteins and their annotated locations for NP_057920.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC123832, AK079077, AK147581
    Consensus CDS
    CCDS23345.1
    UniProtKB/Swiss-Prot
    Q3UH50, Q8BGX9, Q9CUK4, Q9JKK7, Q9JLH9
    Related
    ENSMUSP00000096152.3, ENSMUST00000098552.10
    Conserved Domains (2) summary
    pfam03250
    Location:5146
    Tropomodulin
    cl39015
    Location:215323
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    75472903..75518620 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511268.4XP_006511331.1  tropomodulin-2 isoform X1

    See identical proteins and their annotated locations for XP_006511331.1

    UniProtKB/Swiss-Prot
    Q3UH50, Q8BGX9, Q9CUK4, Q9JKK7, Q9JLH9
    Related
    ENSMUSP00000150413.2, ENSMUST00000215614.2
    Conserved Domains (2) summary
    pfam03250
    Location:5146
    Tropomodulin
    cl39015
    Location:215323
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  2. XM_030244444.2XP_030100304.1  tropomodulin-2 isoform X1

    UniProtKB/Swiss-Prot
    Q3UH50, Q8BGX9, Q9CUK4, Q9JKK7, Q9JLH9
    Conserved Domains (2) summary
    pfam03250
    Location:5146
    Tropomodulin
    cl39015
    Location:215323
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  3. XM_036155101.1XP_036010994.1  tropomodulin-2 isoform X1

    UniProtKB/Swiss-Prot
    Q3UH50, Q8BGX9, Q9CUK4, Q9JKK7, Q9JLH9
    Conserved Domains (2) summary
    pfam03250
    Location:5146
    Tropomodulin
    cl39015
    Location:215323
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  4. XM_006511267.5XP_006511330.1  tropomodulin-2 isoform X1

    See identical proteins and their annotated locations for XP_006511330.1

    UniProtKB/Swiss-Prot
    Q3UH50, Q8BGX9, Q9CUK4, Q9JKK7, Q9JLH9
    Related
    ENSMUSP00000126739.2, ENSMUST00000164100.2
    Conserved Domains (2) summary
    pfam03250
    Location:5146
    Tropomodulin
    cl39015
    Location:215323
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...