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TMOD2 tropomodulin 2 [ Homo sapiens (human) ]

Gene ID: 29767, updated on 7-Oct-2018

Summary

Official Symbol
TMOD2provided by HGNC
Official Full Name
tropomodulin 2provided by HGNC
Primary source
HGNC:HGNC:11872
See related
Ensembl:ENSG00000128872 MIM:602928; Vega:OTTHUMG00000131805
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NTMOD; N-TMOD
Summary
This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2008]
Expression
Biased expression in brain (RPKM 47.3), appendix (RPKM 3.6) and 7 other tissues See more
Orthologs

Genomic context

See TMOD2 in Genome Data Viewer
Location:
15q21.2
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (51751561..51816363)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (52043758..52108560)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene secretogranin III Neighboring gene LysM domain containing 2 Neighboring gene tropomodulin 3 Neighboring gene UTP6, small subunit (SSU) processome component, homolog (yeast) pseudogene Neighboring gene RNA, U6 small nuclear 90, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Pathways from BioSystems

  • Muscle contraction, organism-specific biosystem (from REACTOME)
    Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
  • Striated Muscle Contraction, organism-specific biosystem (from REACTOME)
    Striated Muscle Contraction, organism-specific biosystemStriated muscle contraction is a process whereby force is generated within striated muscle tissue, resulting in a change in muscle geometry, or in short, increased force being exerted on the tendons....

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC39481

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
tropomyosin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
learning or memory IEA
Inferred from Electronic Annotation
more info
 
muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
myofibril assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
neuron-neuron synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
pointed-end actin filament capping IEA
Inferred from Electronic Annotation
more info
 
positive regulation of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
growth cone IEA
Inferred from Electronic Annotation
more info
 
myofibril IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
striated muscle thin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tropomodulin-2
Names
neuronal tropomodulin
tropomodulin 2 (neuronal)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142885.1NP_001136357.1  tropomodulin-2 isoform b

    See identical proteins and their annotated locations for NP_001136357.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region compared to variant 1. The encoded protein (isoform b) is shorter compared to isoform a.
    Source sequence(s)
    AC026770, AC090971, AK293823, DA808222
    Consensus CDS
    CCDS45260.1
    UniProtKB/Swiss-Prot
    Q9NZR1
    Related
    ENSP00000404590.2, OTTHUMP00000248755, ENST00000435126.6, OTTHUMT00000419222
    Conserved Domains (2) summary
    cd00116
    Location:197287
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam03250
    Location:5146
    Tropomodulin; Tropomodulin
  2. NM_014548.3NP_055363.1  tropomodulin-2 isoform a

    See identical proteins and their annotated locations for NP_055363.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC090971, BC064961, DA808222
    Consensus CDS
    CCDS10144.1
    UniProtKB/Swiss-Prot
    Q9NZR1
    Related
    ENSP00000249700.4, OTTHUMP00000162617, ENST00000249700.8, OTTHUMT00000254742
    Conserved Domains (2) summary
    pfam03250
    Location:5146
    Tropomodulin; Tropomodulin
    cl26161
    Location:215323
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

    Range
    51751561..51816363
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022089.2XP_016877578.1  tropomodulin-2 isoform X1

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