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TMOD2 tropomodulin 2 [ Homo sapiens (human) ]

Gene ID: 29767, updated on 17-Sep-2024

Summary

Official Symbol
TMOD2provided by HGNC
Official Full Name
tropomodulin 2provided by HGNC
Primary source
HGNC:HGNC:11872
See related
Ensembl:ENSG00000128872 MIM:602928; AllianceGenome:HGNC:11872
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NTMOD; N-TMOD
Summary
This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2008]
Expression
Biased expression in brain (RPKM 47.3), appendix (RPKM 3.6) and 7 other tissues See more
Orthologs
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Genomic context

See TMOD2 in Genome Data Viewer
Location:
15q21.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (51751597..51816363)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (49559103..49623854)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (52043794..52108560)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12802 Neighboring gene secretogranin III Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6433 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9405 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9406 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6434 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6435 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6436 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6437 Neighboring gene LysM domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9407 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6438 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6439 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:52079467-52079967 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_39634 Neighboring gene MPRA-validated peak2338 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr15:52121755-52121909 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6441 Neighboring gene tropomodulin 3 Neighboring gene UTP6, small subunit (SSU) processome component, homolog (yeast) pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:52178357-52179122 Neighboring gene RNA, U6 small nuclear 90, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC39481

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tropomyosin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in learning or memory IEA
Inferred from Electronic Annotation
more info
 
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in myofibril assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nervous system development TAS
Traceable Author Statement
more info
PubMed 
involved_in neuron-neuron synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in pointed-end actin filament capping IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in myofibril IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in striated muscle thin filament IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tropomodulin-2
Names
neuronal tropomodulin
tropomodulin 2 (neuronal)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142885.2NP_001136357.1  tropomodulin-2 isoform b

    See identical proteins and their annotated locations for NP_001136357.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region compared to variant 1. The encoded protein (isoform b) is shorter compared to isoform a.
    Source sequence(s)
    AC026770, AC090971, AK293823, DA808222
    Consensus CDS
    CCDS45260.1
    UniProtKB/TrEMBL
    A8K9L8
    Related
    ENSP00000404590.2, ENST00000435126.6
    Conserved Domains (2) summary
    cd00116
    Location:197287
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam03250
    Location:5146
    Tropomodulin; Tropomodulin
  2. NM_014548.4NP_055363.1  tropomodulin-2 isoform a

    See identical proteins and their annotated locations for NP_055363.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC090971, BC064961, DA808222
    Consensus CDS
    CCDS10144.1
    UniProtKB/Swiss-Prot
    B4DEW6, Q9NZR1
    UniProtKB/TrEMBL
    A8K9L8
    Related
    ENSP00000249700.4, ENST00000249700.9
    Conserved Domains (2) summary
    pfam03250
    Location:5146
    Tropomodulin
    cl39015
    Location:215323
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    51751597..51816363
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    49559103..49623854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)