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Tmod4 tropomodulin 4 [ Mus musculus (house mouse) ]

Gene ID: 50874, updated on 31-Mar-2024

Summary

Official Symbol
Tmod4provided by MGI
Official Full Name
tropomodulin 4provided by MGI
Primary source
MGI:MGI:1355285
See related
Ensembl:ENSMUSG00000005628 AllianceGenome:MGI:1355285
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MTMOD; Sk-Tmod
Summary
Enables tropomyosin binding activity. Predicted to be involved in actin filament organization; muscle contraction; and myofibril assembly. Located in striated muscle thin filament. Is expressed in diaphragm; lung; and vertebral axis musculature. Orthologous to human TMOD4 (tropomodulin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in mammary gland adult (RPKM 7.1), heart adult (RPKM 2.8) and 25 other tissues See more
Orthologs
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Genomic context

See Tmod4 in Genome Data Viewer
Location:
3 F2.1; 3 40.74 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95030110..95036520)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95122799..95129209)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha Neighboring gene STARR-seq mESC enhancer starr_08366 Neighboring gene predicted gene, 40095 Neighboring gene predicted gene, 22301 Neighboring gene STARR-seq mESC enhancer starr_08367 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:94914795-94915038 Neighboring gene vacuolar protein sorting 72 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:94937828-94938011 Neighboring gene sodium channel modifier 1 Neighboring gene LysM, putative peptidoglycan-binding, domain containing 1 Neighboring gene microRNA 8099-1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables tropomyosin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables tropomyosin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in myofibril assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in pointed-end actin filament capping IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in myofibril IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in striated muscle thin filament IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in striated muscle thin filament IDA
Inferred from Direct Assay
more info
PubMed 
located_in striated muscle thin filament ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tropomodulin-4
Names
skeletal muscle tropomodulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001428789.1NP_001415718.1  tropomodulin-4

    Status: VALIDATED

    Source sequence(s)
    AC131769
  2. NM_001428790.1NP_001415719.1  tropomodulin-4

    Status: VALIDATED

    Source sequence(s)
    AC131769
  3. NM_016712.5NP_057921.1  tropomodulin-4

    See identical proteins and their annotated locations for NP_057921.1

    Status: VALIDATED

    Source sequence(s)
    AC131769
    Consensus CDS
    CCDS17601.1
    UniProtKB/Swiss-Prot
    Q9JLH8
    UniProtKB/TrEMBL
    Q3UN19
    Related
    ENSMUSP00000005769.7, ENSMUST00000005769.13
    Conserved Domains (2) summary
    pfam03250
    Location:4143
    Tropomodulin
    cl39015
    Location:184286
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    95030110..95036520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319636.1XP_017175125.1  tropomodulin-4 isoform X1

    UniProtKB/Swiss-Prot
    Q9JLH8
    UniProtKB/TrEMBL
    Q3UN19
    Conserved Domains (2) summary
    pfam03250
    Location:4143
    Tropomodulin
    cl39015
    Location:184286
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  2. XM_030252671.2XP_030108531.1  tropomodulin-4 isoform X1

    UniProtKB/Swiss-Prot
    Q9JLH8
    UniProtKB/TrEMBL
    Q3UN19
    Conserved Domains (2) summary
    pfam03250
    Location:4143
    Tropomodulin
    cl39015
    Location:184286
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  3. XM_030252672.2XP_030108532.1  tropomodulin-4 isoform X1

    UniProtKB/Swiss-Prot
    Q9JLH8
    UniProtKB/TrEMBL
    Q3UN19
    Conserved Domains (2) summary
    pfam03250
    Location:4143
    Tropomodulin
    cl39015
    Location:184286
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  4. XM_030252670.2XP_030108530.1  tropomodulin-4 isoform X1

    UniProtKB/Swiss-Prot
    Q9JLH8
    UniProtKB/TrEMBL
    Q3UN19
    Related
    ENSMUSP00000102846.2, ENSMUST00000107227.4
    Conserved Domains (2) summary
    pfam03250
    Location:4143
    Tropomodulin
    cl39015
    Location:184286
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...