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TMOD4 tropomodulin 4 [ Homo sapiens (human) ]

Gene ID: 29765, updated on 2-Mar-2021

Summary

Official Symbol
TMOD4provided by HGNC
Official Full Name
tropomodulin 4provided by HGNC
Primary source
HGNC:HGNC:11874
See related
Ensembl:ENSG00000163157 MIM:605834
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SK-TMOD
Expression
Biased expression in prostate (RPKM 6.3), esophagus (RPKM 3.1) and 4 other tissues See more
Orthologs
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Genomic context

See TMOD4 in Genome Data Viewer
Location:
1q21.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (151169986..151175981, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151142463..151148457, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene semaphorin 6C Neighboring gene TNFAIP8L2-SCNM1 readthrough Neighboring gene LysM domain containing 1 Neighboring gene TNF alpha induced protein 8 like 2 Neighboring gene sodium channel modifier 1 Neighboring gene vacuolar protein sorting 72 homolog Neighboring gene phosphatidylinositol-4-phosphate 5-kinase type 1 alpha

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp779I0852

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin filament binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
tropomyosin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
myofibril assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pointed-end actin filament capping IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
myofibril IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
striated muscle thin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
striated muscle thin filament IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tropomodulin-4
Names
actin-capping protein
skeletal muscle tropomodulin
skeletal tropomodulin
tropomodulin 4 (muscle)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013353.3NP_037485.2  tropomodulin-4

    See identical proteins and their annotated locations for NP_037485.2

    Status: VALIDATED

    Source sequence(s)
    AF177173
    Consensus CDS
    CCDS988.1
    UniProtKB/Swiss-Prot
    Q9NZQ9
    Related
    ENSP00000295314.4, ENST00000295314.9
    Conserved Domains (2) summary
    pfam03250
    Location:4143
    Tropomodulin
    cl39015
    Location:184286
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    151169986..151175981 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509449.1XP_011507751.1  tropomodulin-4 isoform X1

    See identical proteins and their annotated locations for XP_011507751.1

    UniProtKB/Swiss-Prot
    Q9NZQ9
    Conserved Domains (2) summary
    pfam03250
    Location:4143
    Tropomodulin
    cl39015
    Location:184286
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  2. XM_017001090.2XP_016856579.1  tropomodulin-4 isoform X2

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