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RNF141 ring finger protein 141 [ Homo sapiens (human) ]

Gene ID: 50862, updated on 21-Dec-2019

Summary

Official Symbol
RNF141provided by HGNC
Official Full Name
ring finger protein 141provided by HGNC
Primary source
HGNC:HGNC:21159
See related
Ensembl:ENSG00000110315 MIM:616641
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFP26; RFP141; ZNF230
Summary
The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-DNA and protein-protein interactions. Abundant expression of this gene was found in the testicular tissue of fertile men, but was not detected in azoospermic patients. Studies of the mouse counterpart suggest that this gene may function as a testis specific transcription factor during spermatogenesis. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 30.2), esophagus (RPKM 28.2) and 25 other tissues See more
Orthologs

Genomic context

See RNF141 in Genome Data Viewer
Location:
11p15.4; 11p15
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (10511673..10541187, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (10533225..10562774, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene adenosine monophosphate deaminase 3 Neighboring gene MT-RNR2 like 8 Neighboring gene microRNA 4485 Neighboring gene MRVI1 antisense RNA 1 Neighboring gene lymphatic vessel endothelial hyaluronan receptor 1 Neighboring gene murine retrovirus integration site 1 homolog

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC8715

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
protein autoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein autoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
RING finger protein 141
Names
C3HC4-like zinc finger protein
zinc finger protein 230

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016422.4NP_057506.2  RING finger protein 141

    See identical proteins and their annotated locations for NP_057506.2

    Status: REVIEWED

    Source sequence(s)
    AC021914, AI356880, AI912940, AL598903, AL600289, BC018104, BF970569, BG108453, BQ229248, BU679024, CB956484
    Consensus CDS
    CCDS7803.1
    UniProtKB/Swiss-Prot
    Q8WVD5
    Related
    ENSP00000265981.2, ENST00000265981.7
    Conserved Domains (1) summary
    cd16545
    Location:154192
    RING-HC_RNF141; RING finger, HC subclass, found in RING finger protein 141 (RNF141) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    10511673..10541187 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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