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Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 50791, updated on 5-Mar-2024

Summary

Official Symbol
Magi2provided by MGI
Official Full Name
membrane associated guanylate kinase, WW and PDZ domain containing 2provided by MGI
Primary source
MGI:MGI:1354953
See related
Ensembl:ENSMUSG00000040003 AllianceGenome:MGI:1354953
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AIP-1; Acvri1; Magi-2; S-SCAM; Acvrip1; Acvrinp1; mKIAA0705
Summary
Enables SMAD binding activity and type II activin receptor binding activity. Involved in several processes, including SMAD protein signal transduction; neuroligin clustering involved in postsynaptic membrane assembly; and positive regulation of synaptic vesicle clustering. Acts upstream of or within signal transduction. Located in cytoplasm; dendrite; and plasma membrane. Is expressed in several structures, including branchial arch; genitourinary system; limb; nervous system; and vibrissa. Used to study schizophrenia. Human ortholog(s) of this gene implicated in nephrotic syndrome type 15. Orthologous to human MAGI2 (membrane associated guanylate kinase, WW and PDZ domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 7.1), frontal lobe adult (RPKM 6.2) and 15 other tissues See more
Orthologs
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Genomic context

See Magi2 in Genome Data Viewer
Location:
5 A3; 5 8.6 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (19431787..20909790)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (19219387..20704792)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12523 Neighboring gene predicted gene, 23822 Neighboring gene STARR-seq mESC enhancer starr_12524 Neighboring gene STARR-seq mESC enhancer starr_12525 Neighboring gene STARR-seq mESC enhancer starr_12526 Neighboring gene STARR-seq mESC enhancer starr_12527 Neighboring gene RIKEN cDNA 4921504A21 gene Neighboring gene STARR-seq mESC enhancer starr_12528 Neighboring gene predicted gene, 32102 Neighboring gene lamin B2 pseudogene Neighboring gene predicted gene, 25335 Neighboring gene predicted gene, 52766 Neighboring gene STARR-seq mESC enhancer starr_12532 Neighboring gene STARR-seq mESC enhancer starr_12533 Neighboring gene predicted gene, 54322 Neighboring gene STARR-seq mESC enhancer starr_12534 Neighboring gene VISTA enhancer mm43 Neighboring gene STARR-seq mESC enhancer starr_12535 Neighboring gene predicted gene, 23570 Neighboring gene predicted gene, 25761 Neighboring gene STARR-seq mESC enhancer starr_12536 Neighboring gene VISTA enhancer mm389 Neighboring gene STARR-seq mESC enhancer starr_12539 Neighboring gene predicted gene, 52764 Neighboring gene STARR-seq mESC enhancer starr_12541 Neighboring gene STARR-seq mESC enhancer starr_12543 Neighboring gene STARR-seq mESC enhancer starr_12544 Neighboring gene STARR-seq mESC enhancer starr_12546 Neighboring gene STARR-seq mESC enhancer starr_12547 Neighboring gene mitochondrial ribosomal protein S36 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12550 Neighboring gene predicted gene, 52763 Neighboring gene ribosomal protein L31, pseudogene 5 Neighboring gene predicted gene, 52806 Neighboring gene putative homeodomain transcription factor 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables activin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables beta-1 adrenergic receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables beta-1 adrenergic receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor complex adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables signaling receptor complex adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor complex adaptor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables structural constituent of postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of postsynaptic specialization ISO
Inferred from Sequence Orthology
more info
 
enables type II activin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables type II activin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in SMAD protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to nerve growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in clathrin-dependent endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of activin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in nerve growth factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuroligin clustering involved in postsynaptic membrane assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic vesicle clustering IDA
Inferred from Direct Assay
more info
PubMed 
involved_in receptor clustering IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in receptor clustering ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic membrane adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within signal transduction IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centriole IDA
Inferred from Direct Assay
more info
PubMed 
located_in ciliary base IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in extrinsic component of postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in photoreceptor inner segment IDA
Inferred from Direct Assay
more info
PubMed 
located_in photoreceptor outer segment IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in slit diaphragm ISO
Inferred from Sequence Orthology
more info
 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
Names
activin receptor interacting protein 1
atrophin-1-interacting protein 1
membrane-associated guanylate kinase inverted 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170745.1NP_001164216.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001164216.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus and lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AK147530, BG297092
    Consensus CDS
    CCDS51425.1
    UniProtKB/TrEMBL
    Q80TU0
    Related
    ENSMUSP00000099094.4, ENSMUST00000101558.10
    Conserved Domains (6) summary
    smart00228
    Location:597683
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:9611041
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:140169
    WW; WW domain
    pfam16663
    Location:3495
    MAGI_u1; Unstructured region on MAGI
    pfam16666
    Location:518592
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:1127
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  2. NM_001170746.1NP_001164217.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001164217.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC113596, AC121774, AC125138, AC132570, AC157608, AC158141, AC161494, AC161802
    Consensus CDS
    CCDS51424.1
    UniProtKB/Swiss-Prot
    Q3UH81, Q6GT88, Q8BYT1, Q8CA85, Q9WVQ1
    UniProtKB/TrEMBL
    Q80TU0
    Related
    ENSMUSP00000085872.4, ENSMUST00000088516.10
    Conserved Domains (6) summary
    smart00072
    Location:118290
    GuKc; Guanylate kinase homologues
    smart00228
    Location:774860
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00201
    Location:304334
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:11381218
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:349378
    WW; WW domain
    pfam16666
    Location:681755
    MAGI_u5; Unstructured region on MAGI
  3. NM_015823.3NP_056638.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_056638.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC157608, AK147530, BC059005
    Consensus CDS
    CCDS39019.1
    UniProtKB/TrEMBL
    Q80TU0
    Related
    ENSMUSP00000110922.3, ENSMUST00000115267.7
    Conserved Domains (6) summary
    smart00228
    Location:611697
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:9751055
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:140169
    WW; WW domain
    pfam16663
    Location:3495
    MAGI_u1; Unstructured region on MAGI
    pfam16666
    Location:518592
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:1127
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    19431787..20909790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535751.5XP_006535814.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X7

    See identical proteins and their annotated locations for XP_006535814.1

    UniProtKB/TrEMBL
    Q80TU0
    Conserved Domains (5) summary
    smart00228
    Location:774860
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:11381218
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:303332
    WW; WW domain
    pfam16666
    Location:681755
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:118290
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  2. XM_006535747.5XP_006535810.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    Q80TU0
    Conserved Domains (5) summary
    smart00228
    Location:774860
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:11381218
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:303332
    WW; WW domain
    pfam16666
    Location:681755
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:118290
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  3. XM_006535743.5XP_006535806.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JE00, Q80TU0
    Related
    ENSMUSP00000142576.2, ENSMUST00000197354.5
    Conserved Domains (7) summary
    smart00228
    Location:774860
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03307
    Location:12551407
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:11381218
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:303332
    WW; WW domain
    pfam16663
    Location:12451285
    MAGI_u1; Unstructured region on MAGI
    pfam16666
    Location:681755
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:118290
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  4. XM_006535748.5XP_006535811.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X5

    UniProtKB/TrEMBL
    Q80TU0
    Conserved Domains (5) summary
    smart00072
    Location:118290
    GuKc; Guanylate kinase homologues
    smart00228
    Location:760846
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:11241204
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:303332
    WW; WW domain
    pfam16666
    Location:681755
    MAGI_u5; Unstructured region on MAGI
  5. XM_006535745.5XP_006535808.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JEG6, Q80TU0
    Related
    ENSMUSP00000142764.2, ENSMUST00000197443.5
    Conserved Domains (7) summary
    smart00228
    Location:760846
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03307
    Location:12411393
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:11241204
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:303332
    WW; WW domain
    pfam16663
    Location:12311271
    MAGI_u1; Unstructured region on MAGI
    pfam16666
    Location:681755
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:118290
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  6. XM_006535744.5XP_006535807.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    Q80TU0
    Conserved Domains (6) summary
    smart00228
    Location:772858
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03307
    Location:12531405
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:11361216
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:303332
    WW; WW domain
    pfam16663
    Location:12431283
    MAGI_u1; Unstructured region on MAGI
    cl17190
    Location:118290
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  7. XM_036165261.1XP_036021154.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X6

    UniProtKB/TrEMBL
    Q80TU0
    Conserved Domains (8) summary
    smart00456
    Location:186217
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:611697
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03307
    Location:10921244
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:9751055
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:140169
    WW; WW domain
    pfam16663
    Location:3495
    MAGI_u1; Unstructured region on MAGI
    pfam16666
    Location:523594
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:1127
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  8. XM_006535750.5XP_006535813.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X6

    See identical proteins and their annotated locations for XP_006535813.1

    UniProtKB/TrEMBL
    Q80TU0
    Conserved Domains (8) summary
    smart00456
    Location:186217
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:611697
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03307
    Location:10921244
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:9751055
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:140169
    WW; WW domain
    pfam16663
    Location:3495
    MAGI_u1; Unstructured region on MAGI
    pfam16666
    Location:523594
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:1127
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  9. XM_036165262.1XP_036021155.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X9

    UniProtKB/TrEMBL
    Q80TU0
    Conserved Domains (7) summary
    smart00456
    Location:127158
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:552638
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03307
    Location:10331185
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5104
    Location:53126
    PRP40; Splicing factor [RNA processing and modification]
    cd00992
    Location:916996
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:81110
    WW; WW domain
    pfam16666
    Location:464535
    MAGI_u5; Unstructured region on MAGI
  10. XM_006535749.5XP_006535812.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X6

    See identical proteins and their annotated locations for XP_006535812.1

    UniProtKB/TrEMBL
    Q80TU0
    Conserved Domains (8) summary
    smart00456
    Location:186217
    WW; Domain with 2 conserved Trp (W) residues
    smart00228
    Location:611697
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03307
    Location:10921244
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:9751055
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:140169
    WW; WW domain
    pfam16663
    Location:3495
    MAGI_u1; Unstructured region on MAGI
    pfam16666
    Location:523594
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:1127
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  11. XM_017320968.3XP_017176457.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X8

    UniProtKB/TrEMBL
    Q80TU0
    Conserved Domains (7) summary
    smart00228
    Location:597683
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03307
    Location:10781230
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:9611041
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00397
    Location:140169
    WW; WW domain
    pfam16663
    Location:3495
    MAGI_u1; Unstructured region on MAGI
    pfam16666
    Location:518592
    MAGI_u5; Unstructured region on MAGI
    cl17190
    Location:1127
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  12. XM_030254656.2XP_030110516.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X11

    UniProtKB/TrEMBL
    A0A140LHL1
    Conserved Domains (4) summary
    smart00228
    Location:382468
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03307
    Location:8631015
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:746826
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16663
    Location:853893
    MAGI_u1; Unstructured region on MAGI
  13. XM_006535752.5XP_006535815.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X10

    UniProtKB/TrEMBL
    A0A140LHL1
    Related
    ENSMUSP00000146769.2, ENSMUST00000197553.5
    Conserved Domains (5) summary
    smart00228
    Location:384470
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03307
    Location:8651017
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:748828
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16663
    Location:855895
    MAGI_u1; Unstructured region on MAGI
    pfam16666
    Location:291365
    MAGI_u5; Unstructured region on MAGI
  14. XM_030254657.2XP_030110517.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X12

    UniProtKB/TrEMBL
    A0A140LHL1
    Conserved Domains (5) summary
    smart00228
    Location:370456
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    PHA03307
    Location:8511003
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:734814
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16663
    Location:841881
    MAGI_u1; Unstructured region on MAGI
    pfam16666
    Location:291365
    MAGI_u5; Unstructured region on MAGI

RNA

  1. XR_004942531.1 RNA Sequence