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Rgs11 regulator of G-protein signaling 11 [ Mus musculus (house mouse) ]

Gene ID: 50782, updated on 12-May-2024

Summary

Official Symbol
Rgs11provided by MGI
Official Full Name
regulator of G-protein signaling 11provided by MGI
Primary source
MGI:MGI:1354739
See related
Ensembl:ENSMUSG00000024186 AllianceGenome:MGI:1354739
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in dendrite terminus. Is expressed in several structures, including lower jaw molar; nervous system; pancreas; seminiferous cord; and sensory organ epithelium. Orthologous to human RGS11 (regulator of G protein signaling 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 27.8), ovary adult (RPKM 17.3) and 18 other tissues See more
Orthologs
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Genomic context

Location:
17 A3.3; 17 13.07 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26421500..26430295)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (26202527..26211324)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene protein disulfide isomerase associated 2 Neighboring gene Rho GDP dissociation inhibitor gamma Neighboring gene family with sequence similarity 234, member A Neighboring gene predicted gene, 23123 Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G-protein beta-subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activator activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cell tip IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite terminus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
regulator of G-protein signaling 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081069.3NP_001074538.1  regulator of G-protein signaling 11

    See identical proteins and their annotated locations for NP_001074538.1

    Status: VALIDATED

    Source sequence(s)
    AC126438
    Consensus CDS
    CCDS37511.1
    UniProtKB/TrEMBL
    E9QNN3, G3X8W6
    Related
    ENSMUSP00000025020.6, ENSMUST00000025020.6
    Conserved Domains (3) summary
    smart00224
    Location:224284
    GGL; G protein gamma subunit-like motifs
    cd04450
    Location:26113
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    cl02565
    Location:295420
    RGS; Regulator of G protein signaling (RGS) domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    26421500..26430295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249893.2XP_030105753.1  regulator of G-protein signaling 11 isoform X1

    Related
    ENSMUST00000147220.8
    Conserved Domains (3) summary
    smart00224
    Location:56116
    GGL; G protein gamma subunit-like motifs
    pfam18148
    Location:341
    RGS_DHEX; Regulator of G-protein signalling DHEX domain
    cl02565
    Location:127252
    RGS; Regulator of G protein signaling (RGS) domain superfamily